mRNA m6A methyltransferase complex in Drosophila melanogaster

N6-methyladenosine (m6A) is deposited on mRNA co-transcriptionally by a methyltransferase complex. Its catalytic core is the Mettl3-Mettl14 heterodimer, in which Mettl3 is the active methyltransferase and Mettl14 an inactive partner that supports RNA binding. A regulatory subcomplex (MACOM) of Fl(2)d, Virilizer (vir), the E3 ligase Hakai, Flacc and the RNA-binding protein Spenito (nito) is required for m6A deposition and specificity. In Drosophila, m6A modification by this complex regulates Sex-lethal pre-mRNA splicing in sex determination and contributes to neuronal function.

MODULE:dmel_m6a_methyltransferase_complexDRAFTCONCRETEProtein Complexmodules/dmel_m6a_methyltransferase_complex.yaml
RNA N6-methyladenosine methyltransferase complexGO:0036396
FB:FBgg0000702
FlyBase gene group MTC: M6a methyltransferase complex
FlyBase release FB2026_03 groups 7 D. melanogaster genes as m6a methyltransferase complex (MTC); this module models that group.
GO:0036396
RNA N6-methyladenosine methyltransferase complex
GO term grounding the module as RNA N6-methyladenosine methyltransferase complex.

Boundary. m6A readers (Ythdc1, Ythdf) and the snRNA methyltransferase Mettl16 are outside the module. FlyBase groups realized by this module: MTC (FBgg0000702). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_m6a_methyltransferase_complex.yaml. None of the member genes has a gene review in this repository yet.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_m6a_methyltransferase_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
mettl3_mettl14_complex/mettl3 Mettl3
UniProtKB:Q9VCE6
Complex Unit 		mRNA m(6)A methyltransferase activity
GO:0001734 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/7 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Hakai M9PBE2 ✗ — —
nito Q7KMJ6 ✗ — —
Mettl3 Q9VCE6 ✗ — —
Mettl14 Q9VLP7 ✗ — —
Flacc Q9VWN4 ✗ — —
vir Q9W1R5 ✗ — —
fl(2)d Q9Y091 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
m6A methyltransferase complexProtein Complexdmel_m6a_methyltransferase_complex

Mettl3-Mettl14 methyltransferase and its Fl(2)d-Vir-Hakai-Flacc-Nito regulatory subcomplex, which deposit m6A on mRNA.

RNA N6-methyladenosine methyltransferase complexGO:0036396
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
Part 1: m6A methyltransferase
Mettl3-Mettl14 catalytic coreProtein Complexmettl3_mettl14

Annotons

Mettl3-Mettl14 catalytic core
mettl3_mettl14_complex
Participant: Protein Complex: Mettl3-Mettl14 catalytic core
Protein Complex:
Mettl3-Mettl14 catalytic core
Active units:
Mettl3
Participant: Gene Product: Mettl3
Gene Product:
Mettl3UniProtKB:Q9VCE6
Function:
mRNA m(6)A methyltransferase activityGO:0001734
Mettl14
Participant: Gene Product: Mettl14
Gene Product:
Mettl14UniProtKB:Q9VLP7
Part 2: complex targeting and stability
Fl(2)d-associated regulatory subcomplex (MACOM)Protein Complexmacom

Annotons

Fl(2)d-associated regulatory subcomplex (MACOM)
macom_complex
Participant: Protein Complex: Fl(2)d-associated regulatory subcomplex (MACOM)
Protein Complex:
Fl(2)d-associated regulatory subcomplex (MACOM)
Active units:
fl(2)d
Participant: Gene Product: fl(2)d
Gene Product:
fl(2)dUniProtKB:Q9Y091
vir
Participant: Gene Product: vir
Gene Product:
virUniProtKB:Q9W1R5
Hakai
Participant: Gene Product: Hakai
Gene Product:
HakaiUniProtKB:M9PBE2
Flacc
Participant: Gene Product: Flacc
Gene Product:
FlaccUniProtKB:Q9VWN4
nito
Participant: Gene Product: nito
Gene Product:
nitoUniProtKB:Q7KMJ6