The mitochondrial contact site and cristae organizing system (MICOS) is an inner membrane complex enriched at crista junctions. It stabilises crista junctions, shapes cristae and links the inner membrane to the outer membrane. MICOS is made of two subcomplexes: a Mic60 subcomplex, built on Mitofilin (Mic60) with the CHCH-domain protein Chchd3 (Mic19), and a Mic10 subcomplex containing the membrane-bending protein Mic10 together with QIL1 (Mic13) and the apolipoprotein-domain protein Mic26-27. Drosophila has three Mic10 paralogs: Mic10b is broadly expressed, whereas Mic10a and Mic10c are testis-specific.
The three FlyBase MICOS variants differ only in the Mic10 paralog and are modelled as one complex with a Mic10 variant set. The assignment of subunits to the Mic60 and Mic10 subcomplexes follows the conserved yeast and mammalian organisation. No molecular function is assigned: MICOS is treated as a structural complex that organizes cristae junctions; apart from structural molecule activity for Mic10b (IDA), its subunits have only ND molecular function annotations in GOA. FlyBase groups realized by this module: MICOS (FBgg0001942). Subgroups folded into it: MICOS-C10B, MICOS-C10C, MICOS-C10A. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_micos_complex.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_micos_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Mic10b A0ACM8PYL1 | ✗ | — | — |
| Mitofilin P91928 | ✗ | — | — |
| Chchd3 Q9VA18 | ✗ | — | — |
| Mic26-27 Q9VEY5 | ✗ | — | — |
| QIL1 Q9VVH3 | ✗ | — | — |
| Mic10a Q9VY65 | ✗ | — | — |
| Mic10c Q9W1B2 | ✗ | — | — |
Inner mitochondrial membrane complex of Mic60 and Mic10 subcomplexes that organises crista junctions and cristae.