The mitochondrial calcium uniporter carries Ca2+ across the inner mitochondrial membrane, driven by the membrane potential. The pore is formed by MCU together with the small single-pass protein EMRE, which is required for uniporter activity in animals. On the intermembrane space side, the EF-hand proteins of the MICU family act as Ca2+-sensing gatekeepers that keep the channel closed at resting Ca2+ and open it when Ca2+ rises. FlyBase defines a complex with MICU1 and MICU3 and a variant in which the EF-hand protein CG4704 takes the place of MICU1.
The two FlyBase uniporter groups share MCU, EMRE and MICU3 and differ in the MICU1-like subunit, so they are modelled as one pore part plus a gatekeeper variant set. The FlyBase CG4704 variant group is tagged as testis-related (MCUNI-T); its tissue restriction is taken from FlyBase. FlyBase groups realized by this module: MCU-CPXS (FBgg0001891). Subgroups folded into it: MCUNI, MCUNI-T. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_mitochondrial_calcium_uniporter.yaml. Member genes with a gene review in this repository: CG4704, EMRE, MCU, MICU1, MICU3.
All recommended fields populated.
✗ none found
No MODULE:dmel_mitochondrial_calcium_uniporter deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| mcu_pore_complex/mcu | MCU UniProtKB:Q8IQ70 Complex Unit |
calcium channel activity GO:0005262 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
5 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| CG4704 Q9VCT5 | ✓ | ✓ | ✓ |
| EMRE Q7JX57 | ✓ | ✓ | ✓ |
| MCU Q8IQ70 | ✓ | ✓ | ✓ |
| MICU1 A2VEI2 | ✓ | ✓ | ✓ |
| MICU3 A0A0B4KHF1 | ✓ | ✓ | ✓ |
MCU-EMRE pore with MICU gatekeepers that takes up Ca2+ into the mitochondrial matrix.