Mitochondrial degradosome in Drosophila melanogaster

The mitochondrial degradosome degrades mitochondrial RNA in the matrix. It is formed by the ATP-dependent RNA helicase Suv3, which unwinds structured RNA, and the exoribonuclease PNPase, which degrades RNA 3' to 5' by phosphorolysis. The complex turns over mRNAs and removes non-coding and antisense transcripts produced by the bidirectional transcription of the mitochondrial genome.

MODULE:dmel_mitochondrial_degradosomeDRAFTCONCRETEProtein Complexmodules/dmel_mitochondrial_degradosome.yaml
mitochondrial degradosomeGO:0045025
FB:FBgg0002143
FlyBase gene group MITDEG: Mitochondrial degradosome
FlyBase release FB2026_03 groups 2 D. melanogaster genes as mitochondrial degradosome (MITDEG); this module models that group.
GO:0045025
mitochondrial degradosome
GO term grounding the module as mitochondrial degradosome.

FlyBase groups realized by this module: MITDEG (FBgg0002143). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_mitochondrial_degradosome.yaml. Member genes with a gene review in this repository: PNPase, Suv3.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_mitochondrial_degradosome deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_mitochondrial_degradosome_pnpase_pnpase PNPase
UniProtKB:Q9V9X7
Gene 		polyribonucleotide nucleotidyltransferase activity
GO:0004654 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
dmel_mitochondrial_degradosome_suv3_suv3 Suv3
UniProtKB:Q9VN03
Gene 		RNA helicase activity
GO:0003724 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
PNPase Q9V9X7 ✓ ✓ ✓
Suv3 Q9VN03 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
Mitochondrial degradosomeProtein Complexdmel_mitochondrial_degradosome

Suv3 helicase and PNPase exoribonuclease complex that degrades mitochondrial RNA.

mitochondrial degradosomeGO:0045025
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: 3'-5' exoribonuclease subunit
PNPaseModuledmel_mitochondrial_degradosome_pnpase

Annotons

PNPase subunit
dmel_mitochondrial_degradosome_pnpase_pnpase
Participant: Gene Product: PNPase
Gene Product:
PNPaseUniProtKB:Q9V9X7

Function

polyribonucleotide nucleotidyltransferase activityGO:0004654

3'-5' exoribonuclease subunit

Part 2: RNA helicase subunit
Suv3Moduledmel_mitochondrial_degradosome_suv3

Annotons

Suv3 subunit
dmel_mitochondrial_degradosome_suv3_suv3
Participant: Gene Product: Suv3
Gene Product:
Suv3UniProtKB:Q9VN03

Function

RNA helicase activityGO:0003724

RNA helicase subunit