Mitochondria carry their own type II fatty acid synthesis (mtFAS) system, in which separate enzymes act on acyl chains attached to the mitochondrial acyl carrier protein (ND-ACP). Malonyl groups are loaded onto ACP by the malonyl transacylase (beg), condensed by a beta-ketoacyl-ACP synthase (CG12170), reduced by a 3-ketoacyl-ACP reductase, dehydrated and then reduced by the enoyl-ACP reductase Mecr. The main product, octanoyl-ACP, is the precursor of lipoic acid; acylated ACP also binds and supports assembly of respiratory complex I and the iron-sulfur cluster assembly machinery.
Boundary and caveats. The 3-hydroxyacyl-ACP dehydratase step (step 4; HTD2 in mammals) is not in the FlyBase group and is not modelled, so the connection from ketoacyl reduction to enoyl reduction spans it. Acc is a FlyBase member but is best known as the cytosolic acetyl-CoA carboxylase; whether a fly Acc isoform supplies malonyl-CoA inside mitochondria is not established (mammals use ACSF3 for intramitochondrial malonyl-CoA), so it is modelled as the malonyl-CoA supply step without a location claim. CG3603 is assigned to the ketoreductase step by its membership in the FlyBase group; in mammals this step is performed by an HSD17B8-CBR4 heterotetramer and the fly assignment is only by sequence similarity, so no molecular function is given. ND-ACP is also a subunit of respiratory complex I and part of the iron-sulfur cluster assembly complex (module dmel_iron_sulfur_cluster_assembly). Other molecular functions follow orthology and have not been assayed in flies. FlyBase groups realized by this module: MTFABIO (FBgg0002247). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_mitochondrial_fatty_acid_synthesis.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_mitochondrial_fatty_acid_synthesis deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| malonyl_coa_supply_acc | Acc UniProtKB:A1Z784 Gene |
acetyl-CoA carboxylase activity GO:0003989 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| acyl_carrier_nd_acp | ND-ACP UniProtKB:Q94519 Gene |
acyl carrier activity GO:0000036 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| malonyl_transacylation_beg | beg UniProtKB:Q8T3L6 Gene |
[acyl-carrier-protein] S-malonyltransferase activity GO:0004314 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| ketoacyl_condensation_cg12170 | CG12170 UniProtKB:Q9VNF5 Gene |
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| enoyl_reduction_mecr | Mecr UniProtKB:Q9V6U9 Gene |
enoyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0141148 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 6 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Acc A1Z784 | ✗ | — | — |
| beg Q8T3L6 | ✗ | — | — |
| ND-ACP Q94519 | ✗ | — | — |
| Mecr Q9V6U9 | ✗ | — | — |
| CG12170 Q9VNF5 | ✗ | — | — |
| CG3603 Q9W4U2 | ✗ | — | — |
Acyl carrier protein-based fatty acid synthesis in mitochondria that supplies octanoyl chains for lipoic acid synthesis.