Mitochondrial ribosome in Drosophila melanogaster

The mitochondrial ribosome (mitoribosome) translates the small set of mitochondrial-DNA-encoded mRNAs, which in animals encode core subunits of the respiratory chain and ATP synthase. It consists of a small subunit built on the mitochondrially encoded 12S-type rRNA (mt:srRNA) and a large subunit built on the 16S-type rRNA (mt:lrRNA), together with nuclear-encoded mitochondrial ribosomal proteins. Animal mitoribosomes are protein-rich: they contain bacterial-type ribosomal proteins plus many mitochondria-specific proteins. In Drosophila, loss of the small-subunit protein tko (mRpS12) causes the technical knockout phenotype of bang sensitivity.

MODULE:dmel_mitochondrial_ribosomeDRAFTCONCRETEProtein Complexmodules/dmel_mitochondrial_ribosome.yaml
mitochondrial ribosomeGO:0005761
FB:FBgg0000059
FlyBase gene group MRP: Mitochondrial ribosomal subunits
FlyBase release FB2026_03 groups 83 D. melanogaster genes as mitochondrial ribosomal subunits (MRP); this module models that group.
GO:0005761
mitochondrial ribosome
GO term grounding the module as mitochondrial ribosome.

Parts follow the FlyBase subgroups MRPS and MRPL, which include the mitochondrially encoded rRNAs (mt:srRNA, mt:lrRNA) grounded to their FlyBase gene ids. FlyBase lists mRpS30 in both subunits and mRpS18A in the large subunit group; these placements are kept as curated by FlyBase. Some members of MRPS (for example Ptcd3, bonsai, CG4882, CG12848) carry non-ribosomal-protein names; they are kept as FlyBase-listed subunit members. FlyBase groups realized by this module: MRP (FBgg0000059). Subgroups folded into it: MRPS, MRPL. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_mitochondrial_ribosome.yaml. Genes without a usable UniProtKB entry are grounded to their FlyBase gene ids: mt:lrRNA, mt:srRNA. None of the member genes has a gene review in this repository yet.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_mitochondrial_ribosome deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
mito_small_subunit_complex PROTEIN_COMPLEX
Gene 		structural constituent of ribosome
GO:0003735 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.
mito_large_subunit_complex PROTEIN_COMPLEX
Gene 		structural constituent of ribosome
GO:0003735 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.

Gene-review completeness (0/81 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 81 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
mRpL42 A1Z839 ✗ — —
mRpL18 A1Z953 ✗ — —
Ptcd3 A1Z9A8 ✗ — —
mRpL53 A1Z9J6 ✗ — —
mRpS28 A1ZBA5 ✗ — —
CG4882 O77477 ✗ — —
tko P10735 ✗ — —
mRpS5 Q0E8A8 ✗ — —
mRpL34 Q0E959 ✗ — —
mRpL52 Q7JWG9 ✗ — —
mRpL41 Q7JZM8 ✗ — —
mRpL47 Q7KST0 ✗ — —
mRpS9 Q7KSW6 ✗ — —
mRpS2 Q7KU48 ✗ — —
mRpL27 Q86BM8 ✗ — —
mRpS21 Q8I0J3 ✗ — —
mRpS23 Q8IP62 ✗ — —
mRpL35 Q8MS27 ✗ — —
bonsai Q8WTC1 ✗ — —
mRpL36 Q9I7Q9 ✗ — —
mRpL4 Q9V3D0 ✗ — —
mRpL50 Q9V3E3 ✗ — —
mRpS16 Q9V6Y3 ✗ — —
mRpL32 Q9V9Z1 ✗ — —
mRpS18C Q9VA81 ✗ — —
mRpS22 Q9VAY9 ✗ — —
mRpS24 Q9VCC3 ✗ — —
mRpL45 Q9VCX3 ✗ — —
mRpL55 Q9VE04 ✗ — —
mRpS11 Q9VEN6 ✗ — —
mRpS33 Q9VEV5 ✗ — —
mRpL9 Q9VF89 ✗ — —
mRpS10 Q9VFB2 ✗ — —
mRpL11 Q9VFJ2 ✗ — —
mRpL40 Q9VGP7 ✗ — —
mRpL37 Q9VGW9 ✗ — —
mRpL19 Q9VHN6 ✗ — —
mRpS18A Q9VHQ0 ✗ — —
mRpL1 Q9VHT5 ✗ — —
mRpS18B Q9VIN9 ✗ — —
mRpL13 Q9VJ38 ✗ — —
CG6094 Q9VKU3 ✗ — —
mRpS7 Q9VKX4 ✗ — —
mRpL51 Q9VLJ9 ✗ — —
mRpL28 Q9VMX0 ✗ — —
mRpL24 Q9VMY1 ✗ — —
mRpL44 Q9VNC1 ✗ — —
CRIF Q9VP13 ✗ — —
mRpL15 Q9VPF6 ✗ — —
mRpL10 Q9VPL3 ✗ — —
mRpL48 Q9VQ35 ✗ — —
mRpL12 Q9VSR5 ✗ — —
mRpL2 Q9VTF8 ✗ — —
mRpL20 Q9VU36 ✗ — —
mRpL39 Q9VUJ0 ✗ — —
mRpS31 Q9VUX1 ✗ — —
mRpS34 Q9VV39 ✗ — —
mRpS26 Q9VVN2 ✗ — —
mRpL21 Q9VVX4 ✗ — —
mRpS14 Q9VWI3 ✗ — —
mRpL22 Q9VXB5 ✗ — —
mRpS30 Q9VXP3 ✗ — —
mRpL3 Q9VXQ0 ✗ — —
mRpS25 Q9VY28 ✗ — —
mRpL38 Q9VY48 ✗ — —
mRpL49 Q9VYI3 ✗ — —
mRpS6 Q9VZD5 ✗ — —
mRpS35 Q9VZX6 ✗ — —
mRpL23 Q9W021 ✗ — —
mRpL46 Q9W086 ✗ — —
mRpL17 Q9W0S6 ✗ — —
CG12848 Q9W114 ✗ — —
mRpS17 Q9W199 ✗ — —
mRpL43 Q9W1L1 ✗ — —
mRpS29 Q9W253 ✗ — —
mRpL54 Q9W2M8 ✗ — —
mRpL30 Q9W4I3 ✗ — —
mRpL33 Q9W4L1 ✗ — —
mRpL14 Q9W4Z2 ✗ — —
mRpL16 Q9W547 ✗ — —
CG14817 Q9W551 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
mitochondrionGO:0005739
Mitochondrial ribosomeProtein Complexdmel_mitochondrial_ribosome

Small and large mitoribosomal subunits that translate mitochondrial-DNA-encoded mRNAs.

mitochondrial ribosomeGO:0005761
Context
Drosophila melanogasterNCBITaxon:7227
mitochondrionGO:0005739
Part 1: mRNA decoding subunit
Mitochondrial small ribosomal subunitProtein Complexmito_small_subunit

Annotons

Mitochondrial small ribosomal subunit
mito_small_subunit_complex
Participant: Protein Complex: Mitochondrial small ribosomal subunit
Protein Complex:
Mitochondrial small ribosomal subunitGO:0005763
Active units:
CG12848
Participant: Gene Product: CG12848
Gene Product:
CG12848UniProtKB:Q9W114
CG4882
Participant: Gene Product: CG4882
Gene Product:
CG4882UniProtKB:O77477
Ptcd3
Participant: Gene Product: Ptcd3
Gene Product:
Ptcd3UniProtKB:A1Z9A8
bonsai
Participant: Gene Product: bonsai
Gene Product:
bonsaiUniProtKB:Q8WTC1
mRpS10
Participant: Gene Product: mRpS10
Gene Product:
mRpS10UniProtKB:Q9VFB2
mRpS11
Participant: Gene Product: mRpS11
Gene Product:
mRpS11UniProtKB:Q9VEN6
mRpS14
Participant: Gene Product: mRpS14
Gene Product:
mRpS14UniProtKB:Q9VWI3
mRpS16
Participant: Gene Product: mRpS16
Gene Product:
mRpS16UniProtKB:Q9V6Y3
mRpS17
Participant: Gene Product: mRpS17
Gene Product:
mRpS17UniProtKB:Q9W199
mRpS18B
Participant: Gene Product: mRpS18B
Gene Product:
mRpS18BUniProtKB:Q9VIN9
mRpS18C
Participant: Gene Product: mRpS18C
Gene Product:
mRpS18CUniProtKB:Q9VA81
mRpS2
Participant: Gene Product: mRpS2
Gene Product:
mRpS2UniProtKB:Q7KU48
mRpS21
Participant: Gene Product: mRpS21
Gene Product:
mRpS21UniProtKB:Q8I0J3
mRpS22
Participant: Gene Product: mRpS22
Gene Product:
mRpS22UniProtKB:Q9VAY9
mRpS23
Participant: Gene Product: mRpS23
Gene Product:
mRpS23UniProtKB:Q8IP62
mRpS24
Participant: Gene Product: mRpS24
Gene Product:
mRpS24UniProtKB:Q9VCC3
mRpS25
Participant: Gene Product: mRpS25
Gene Product:
mRpS25UniProtKB:Q9VY28
mRpS26
Participant: Gene Product: mRpS26
Gene Product:
mRpS26UniProtKB:Q9VVN2
mRpS28
Participant: Gene Product: mRpS28
Gene Product:
mRpS28UniProtKB:A1ZBA5
mRpS29
Participant: Gene Product: mRpS29
Gene Product:
mRpS29UniProtKB:Q9W253
mRpS30
Participant: Gene Product: mRpS30
Gene Product:
mRpS30UniProtKB:Q9VXP3
mRpS31
Participant: Gene Product: mRpS31
Gene Product:
mRpS31UniProtKB:Q9VUX1
mRpS33
Participant: Gene Product: mRpS33
Gene Product:
mRpS33UniProtKB:Q9VEV5
mRpS34
Participant: Gene Product: mRpS34
Gene Product:
mRpS34UniProtKB:Q9VV39
mRpS35
Participant: Gene Product: mRpS35
Gene Product:
mRpS35UniProtKB:Q9VZX6
mRpS5
Participant: Gene Product: mRpS5
Gene Product:
mRpS5UniProtKB:Q0E8A8
mRpS6
Participant: Gene Product: mRpS6
Gene Product:
mRpS6UniProtKB:Q9VZD5
mRpS7
Participant: Gene Product: mRpS7
Gene Product:
mRpS7UniProtKB:Q9VKX4
mRpS9
Participant: Gene Product: mRpS9
Gene Product:
mRpS9UniProtKB:Q7KSW6
mt:srRNA
Participant: Gene: mt:srRNA
Gene:
mt:srRNAFB:FBgn0013688
tko
Participant: Gene Product: tko
Gene Product:
tkoUniProtKB:P10735

Function

structural constituent of ribosomeGO:0003735

Processes

mitochondrial translationGO:0032543
Part 2: peptidyl transferase subunit
Mitochondrial large ribosomal subunitProtein Complexmito_large_subunit

Annotons

Mitochondrial large ribosomal subunit
mito_large_subunit_complex
Participant: Protein Complex: Mitochondrial large ribosomal subunit
Protein Complex:
Mitochondrial large ribosomal subunitGO:0005762
Active units:
CG14817
Participant: Gene Product: CG14817
Gene Product:
CG14817UniProtKB:Q9W551
CG6094
Participant: Gene Product: CG6094
Gene Product:
CG6094UniProtKB:Q9VKU3
CRIF
Participant: Gene Product: CRIF
Gene Product:
CRIFUniProtKB:Q9VP13
mRpL1
Participant: Gene Product: mRpL1
Gene Product:
mRpL1UniProtKB:Q9VHT5
mRpL10
Participant: Gene Product: mRpL10
Gene Product:
mRpL10UniProtKB:Q9VPL3
mRpL11
Participant: Gene Product: mRpL11
Gene Product:
mRpL11UniProtKB:Q9VFJ2
mRpL12
Participant: Gene Product: mRpL12
Gene Product:
mRpL12UniProtKB:Q9VSR5
mRpL13
Participant: Gene Product: mRpL13
Gene Product:
mRpL13UniProtKB:Q9VJ38
mRpL14
Participant: Gene Product: mRpL14
Gene Product:
mRpL14UniProtKB:Q9W4Z2
mRpL15
Participant: Gene Product: mRpL15
Gene Product:
mRpL15UniProtKB:Q9VPF6
mRpL16
Participant: Gene Product: mRpL16
Gene Product:
mRpL16UniProtKB:Q9W547
mRpL17
Participant: Gene Product: mRpL17
Gene Product:
mRpL17UniProtKB:Q9W0S6
mRpL18
Participant: Gene Product: mRpL18
Gene Product:
mRpL18UniProtKB:A1Z953
mRpL19
Participant: Gene Product: mRpL19
Gene Product:
mRpL19UniProtKB:Q9VHN6
mRpL2
Participant: Gene Product: mRpL2
Gene Product:
mRpL2UniProtKB:Q9VTF8
mRpL20
Participant: Gene Product: mRpL20
Gene Product:
mRpL20UniProtKB:Q9VU36
mRpL21
Participant: Gene Product: mRpL21
Gene Product:
mRpL21UniProtKB:Q9VVX4
mRpL22
Participant: Gene Product: mRpL22
Gene Product:
mRpL22UniProtKB:Q9VXB5
mRpL23
Participant: Gene Product: mRpL23
Gene Product:
mRpL23UniProtKB:Q9W021
mRpL24
Participant: Gene Product: mRpL24
Gene Product:
mRpL24UniProtKB:Q9VMY1
mRpL27
Participant: Gene Product: mRpL27
Gene Product:
mRpL27UniProtKB:Q86BM8
mRpL28
Participant: Gene Product: mRpL28
Gene Product:
mRpL28UniProtKB:Q9VMX0
mRpL3
Participant: Gene Product: mRpL3
Gene Product:
mRpL3UniProtKB:Q9VXQ0
mRpL30
Participant: Gene Product: mRpL30
Gene Product:
mRpL30UniProtKB:Q9W4I3
mRpL32
Participant: Gene Product: mRpL32
Gene Product:
mRpL32UniProtKB:Q9V9Z1
mRpL33
Participant: Gene Product: mRpL33
Gene Product:
mRpL33UniProtKB:Q9W4L1
mRpL34
Participant: Gene Product: mRpL34
Gene Product:
mRpL34UniProtKB:Q0E959
mRpL35
Participant: Gene Product: mRpL35
Gene Product:
mRpL35UniProtKB:Q8MS27
mRpL36
Participant: Gene Product: mRpL36
Gene Product:
mRpL36UniProtKB:Q9I7Q9
mRpL37
Participant: Gene Product: mRpL37
Gene Product:
mRpL37UniProtKB:Q9VGW9
mRpL38
Participant: Gene Product: mRpL38
Gene Product:
mRpL38UniProtKB:Q9VY48
mRpL39
Participant: Gene Product: mRpL39
Gene Product:
mRpL39UniProtKB:Q9VUJ0
mRpL4
Participant: Gene Product: mRpL4
Gene Product:
mRpL4UniProtKB:Q9V3D0
mRpL40
Participant: Gene Product: mRpL40
Gene Product:
mRpL40UniProtKB:Q9VGP7
mRpL41
Participant: Gene Product: mRpL41
Gene Product:
mRpL41UniProtKB:Q7JZM8
mRpL42
Participant: Gene Product: mRpL42
Gene Product:
mRpL42UniProtKB:A1Z839
mRpL43
Participant: Gene Product: mRpL43
Gene Product:
mRpL43UniProtKB:Q9W1L1
mRpL44
Participant: Gene Product: mRpL44
Gene Product:
mRpL44UniProtKB:Q9VNC1
mRpL45
Participant: Gene Product: mRpL45
Gene Product:
mRpL45UniProtKB:Q9VCX3
mRpL46
Participant: Gene Product: mRpL46
Gene Product:
mRpL46UniProtKB:Q9W086
mRpL47
Participant: Gene Product: mRpL47
Gene Product:
mRpL47UniProtKB:Q7KST0
mRpL48
Participant: Gene Product: mRpL48
Gene Product:
mRpL48UniProtKB:Q9VQ35
mRpL49
Participant: Gene Product: mRpL49
Gene Product:
mRpL49UniProtKB:Q9VYI3
mRpL50
Participant: Gene Product: mRpL50
Gene Product:
mRpL50UniProtKB:Q9V3E3
mRpL51
Participant: Gene Product: mRpL51
Gene Product:
mRpL51UniProtKB:Q9VLJ9
mRpL52
Participant: Gene Product: mRpL52
Gene Product:
mRpL52UniProtKB:Q7JWG9
mRpL53
Participant: Gene Product: mRpL53
Gene Product:
mRpL53UniProtKB:A1Z9J6
mRpL54
Participant: Gene Product: mRpL54
Gene Product:
mRpL54UniProtKB:Q9W2M8
mRpL55
Participant: Gene Product: mRpL55
Gene Product:
mRpL55UniProtKB:Q9VE04
mRpL9
Participant: Gene Product: mRpL9
Gene Product:
mRpL9UniProtKB:Q9VF89
mRpS18A
Participant: Gene Product: mRpS18A
Gene Product:
mRpS18AUniProtKB:Q9VHQ0
mRpS30
Participant: Gene Product: mRpS30
Gene Product:
mRpS30UniProtKB:Q9VXP3
mt:lrRNA
Participant: Gene: mt:lrRNA
Gene:
mt:lrRNAFB:FBgn0013686

Function

structural constituent of ribosomeGO:0003735

Processes

mitochondrial translationGO:0032543