MuvB is a conserved core of five proteins (Mip130, Mip120, Mip40, Lin-52 and Caf1-55) that assembles with different partners to repress or activate cell-cycle and differentiation genes. With E2F2, Dp and the retinoblastoma-family proteins Rbf or Rbf2 it forms dREAM, which represses E2F target genes and developmentally regulated genes. With the Myb transcription factor it forms the Myb-MuvB complex (MMB), which activates G2/M genes and also controls site-specific chorion gene amplification. In spermatocytes a testis-specific relative, tMAC, which contains Aly, Comr, Tomb and Topi with Mip40 and Caf1-55, activates the meiotic and spermatid differentiation gene program.
The MuvB core is modelled as its own part (FlyBase group MUVB) and also appears within each assembly variant, which list full FlyBase memberships. FlyBase places the dREAM Rbf group (DRM-R) membership to include both Rbf and Rbf2. tMAC is listed under MuvB complexes by FlyBase; it shares Mip40 and Caf1-55 with MuvB and contains testis-specific paralogs (Aly, Tomb) of other MuvB subunits. tMAC has no GO cellular-component term. No molecular function is assigned in this version. The MuvB core has no established catalytic activity; the DNA-binding transcription factors that join it (Myb in the Myb-MuvB complex, E2f2-Dp in dREAM) carry DNA-binding transcription factor activity terms in GOA but are not yet given annoton functions here. FlyBase groups realized by this module: MUVB-C (FBgg0001984), MUVB (FBgg0001987). Subgroups folded into it: DRM-R, DRM-R2, TMAC, MMC. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_muvb_complexes.yaml. Member genes with a gene review in this repository: Caf1-55.
All recommended fields populated.
✗ none found
No MODULE:dmel_muvb_complexes deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 1 with deep research · 13 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| mip120 A1Z9E2 | ✗ | — | — |
| mip40 A1ZBJ0 | ✗ | — | — |
| Caf1-55 Q24572 | ✓ | 90/91 | ✓ |
| E2f2 O77051 | ✗ | — | — |
| Myb P04197 | ✗ | — | — |
| Dp Q24318 | ✗ | — | — |
| Rbf Q24472 | ✗ | — | — |
| Rbf2 Q9VF04 | ✗ | — | — |
| topi Q9VH70 | ✗ | — | — |
| tomb Q9VMQ3 | ✗ | — | — |
| aly Q9VZW3 | ✗ | — | — |
| comr Q9W2C1 | ✗ | — | — |
| lin-52 Q9W482 | ✗ | — | — |
| mip130 Q9W542 | ✗ | — | — |
MuvB core and the dREAM, Myb-MuvB and testis-specific tMAC complexes built on it.