NALCN sodium leak channel complex in Drosophila melanogaster

NALCN is a voltage-insensitive cation channel that carries a background sodium leak current and so sets the resting membrane potential and excitability of neurons. Its pore-forming subunit, encoded in Drosophila by narrow abdomen (na), assembles with the large accessory proteins unc79 and unc80 and with Mid1, a protein related to yeast Mid1 and to the mammalian NALCN accessory factor NALF1 (FAM155A). In flies, na and its partners are needed for normal locomotor activity and circadian rhythmic behavior.

MODULE:dmel_nalcn_channel_complexDRAFTCONCRETEProtein Complexmodules/dmel_nalcn_channel_complex.yaml
sodium channel complexGO:0034706
FB:FBgg0001886
FlyBase gene group NALCN: Sodium leak channel complex
FlyBase release FB2026_03 groups 4 D. melanogaster genes as sodium leak channel complex (NALCN); this module models that group.
FB:FBgg0002195
FlyBase gene group NALCN-CH: Sodium leak channel subunits
FlyBase release FB2026_03 groups 1 D. melanogaster genes as sodium leak channel subunits (NALCN-CH); this module models that group.
GO:0034706
sodium channel complex
GO term grounding the module as sodium channel complex.

The FlyBase NALCN-CH group contains only the pore subunit na, which is already a member of NALCN. Each subunit is modelled as a part; the accessory subunits are not assigned a molecular function. FlyBase groups realized by this module: NALCN (FBgg0001886), NALCN-CH (FBgg0002195). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_nalcn_channel_complex.yaml. Member genes with a gene review in this repository: Mid1, na, unc79, unc80.

5Nodes
4Parts
0Variant Sets
0Variants
4Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_nalcn_channel_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_nalcn_channel_complex_na_na na
UniProtKB:A8JUW5
Gene 		sodium channel activity
GO:0005272 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (4/4 grounded genes reviewed)

4 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Mid1 Q9I7V0 ✓ ✓ ✓
na A8JUW5 ✓ ✓ ✓
unc79 Q9VDY5 ✓ ✓ ✓
unc80 Q9VB11 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
NALCN channel complexProtein Complexdmel_nalcn_channel_complex

Sodium leak channel of the pore subunit na with the accessory subunits unc79, unc80 and Mid1.

sodium channel complexGO:0034706
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: accessory subunit
Mid1Moduledmel_nalcn_channel_complex_mid1

Annotons

Mid1 subunit
dmel_nalcn_channel_complex_mid1_mid1
Participant: Gene Product: Mid1
Gene Product:
Mid1UniProtKB:Q9I7V0

accessory subunit

Part 2: pore-forming subunit
naModuledmel_nalcn_channel_complex_na

Annotons

na subunit
dmel_nalcn_channel_complex_na_na
Participant: Gene Product: na
Gene Product:
naUniProtKB:A8JUW5

Function

sodium channel activityGO:0005272

pore-forming subunit

Part 3: accessory subunit
unc79Moduledmel_nalcn_channel_complex_unc79

Annotons

unc79 subunit
dmel_nalcn_channel_complex_unc79_unc79
Participant: Gene Product: unc79
Gene Product:
unc79UniProtKB:Q9VDY5

accessory subunit

Part 4: accessory subunit
unc80Moduledmel_nalcn_channel_complex_unc80

Annotons

unc80 subunit
dmel_nalcn_channel_complex_unc80_unc80
Participant: Gene Product: unc80
Gene Product:
unc80UniProtKB:Q9VB11

accessory subunit