Outer ring (Nup107-160 Y-complex)
outer_ring_complex
Participant: Protein Complex: Outer ring (Nup107-160 Y-complex)
Protein Complex:
Nuclear pore complex in Drosophila melanogaster
The nuclear pore complex (NPC) is a large assembly of about 30 different nucleoporins, each present in multiple copies, that spans the nuclear envelope and controls traffic between nucleus and cytoplasm. A symmetric core of stacked rings (two outer rings built from the Nup107-160 Y-complex, an inner ring, and a transmembrane ring) anchors a central channel filled with phenylalanine-glycine (FG) repeat nucleoporins that form the permeability barrier. Asymmetric cytoplasmic filaments and a nuclear basket attach to the core and act in mRNA export and in docking of transport receptors. Several Drosophila nucleoporins also act off the pore, for example in gene regulation and in mitosis.
nuclear poreGO:0005643
FB:FBgg0000146
FlyBase gene group NPC: Nuclear pore complex
FlyBase release FB2026_03 groups 31 D. melanogaster genes as nuclear pore complex (NPC); this module models that group.
Sub-structure follows the conserved assignments of the human and yeast homologs; FlyBase lists the nucleoporins as one flat group. Mgtor is the Drosophila Tpr homolog (Megator). No molecular function is assigned: the nuclear pore complex is modelled as a structural assembly. Scaffold nucleoporins carry structural constituent of nuclear pore (GO:0017056) in GOA, mostly by IBA and ISS, but per-subunit structural terms are not added; selective transport is a property of the assembled pore and its FG-repeat network. FlyBase groups realized by this module: NPC (FBgg0000146). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_nuclear_pore_complex.yaml. None of the member genes has a gene review in this repository yet.
8Nodes
7Parts
0Variant Sets
0Variants
8Annotons
0Connections
Derived QC
Recommended-field compliance
100.0%
recommended fields populated
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_nuclear_pore_complex deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
No functional claims were checked. This does not establish consistency with gene or family reviews.
Gene-review completeness (1/31 grounded genes reviewed)
0 complete review(s) · 1 with deep research · 30 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Nup358 A0A0B4K7J2 | ✗ | — | — |
| Nup188 A0A0B4K859 | ✗ | — | — |
| Nup75 A1YK02 | ✗ | — | — |
| Gp210 A1Z6H7 | ✗ | — | — |
| Mgtor A1Z8P9 | ✓ | 81/83 | ✓ |
| Nup62 Q7JXF5 | ✗ | — | — |
| Nup50 Q7K0D8 | ✗ | — | — |
| Nup44A Q7K2X8 | ✗ | — | — |
| Nup205 Q8IQV9 | ✗ | — | — |
| mbo Q9GYU8 | ✗ | — | — |
| CG18787 Q9I7N2 | ✗ | — | — |
| Sec13 Q9V3J4 | ✗ | — | — |
| Nup154 Q9V463 | ✗ | — | — |
| Nup107 Q9V466 | ✗ | — | — |
| Gle1 Q9V4W1 | ✗ | — | — |
| Nup54 Q9V6B9 | ✗ | — | — |
| Nup37 Q9VBU8 | ✗ | — | — |
| Ndc1 Q9VCG4 | ✗ | — | — |
| Nup98-96 Q9VCH5 | ✗ | — | — |
| Nup133 Q9VCW3 | ✗ | — | — |
| Nup58 Q9VDV3 | ✗ | — | — |
| Nup43 Q9VE85 | ✗ | — | — |
| Nup93-2 Q9VFE7 | ✗ | — | — |
| Nup160 Q9VKJ3 | ✗ | — | — |
| Elys Q9VWE6 | ✗ | — | — |
| Nup35 Q9VWS2 | ✗ | — | — |
| Nup153 Q9VXE6 | ✗ | — | — |
| Nup214 Q9W1X4 | ✗ | — | — |
| Rae1 Q9W2E7 | ✗ | — | — |
| Aladin Q9W351 | ✗ | — | — |
| Nup93-1 Q9XZ06 | ✗ | — | — |
Details
Context
Drosophila melanogasterNCBITaxon:7227
nuclear envelopeGO:0005635
Nuclear pore complexProtein Complexdmel_nuclear_pore_complex
Nucleoporin assembly spanning the nuclear envelope, with outer, inner and membrane rings, an FG-repeat central channel, cytoplasmic filaments and a nuclear basket.
nuclear poreGO:0005643
Context
Drosophila melanogasterNCBITaxon:7227
nuclear envelopeGO:0005635
Part 1: outer ring scaffold
Outer ring (Nup107-160 Y-complex)Protein Complexouter_ring
The Y-shaped Nup107-160 complex forms the cytoplasmic and nuclear outer rings. Elys binds the Y-complex and chromatin and seeds post-mitotic pore assembly. Nup98-96 encodes a precursor that is cleaved into the FG nucleoporin Nup98 and the Y-complex subunit Nup96.
Annotons
Part 2: inner ring scaffold
Inner ringProtein Complexinner_ring
The Nup93 and Nup205/Nup188 scaffold, with Nup154 and Nup35, forms the inner ring that links the membrane to the central channel.
Annotons
Inner ring
inner_ring_complex
Participant: Protein Complex: Inner ring
Protein Complex:
Part 3: pore membrane anchors
Transmembrane ringProtein Complextransmembrane_ring
Integral membrane nucleoporins that anchor the NPC in the pore membrane.
Annotons
Transmembrane ring
transmembrane_ring_complex
Participant: Protein Complex: Transmembrane ring
Protein Complex:
Part 4: permeability barrier
Central channel FG nucleoporinsProtein Complexcentral_channel
The Nup62 subcomplex of FG nucleoporins lines the central channel and forms the selective barrier.
Annotons
Central channel FG nucleoporins
central_channel_complex
Participant: Protein Complex: Central channel FG nucleoporins
Protein Complex:
Part 5: cytoplasmic face, mRNA export
Cytoplasmic filamentsProtein Complexcytoplasmic_filaments
Nup358 (RanBP2), Nup214 and Nup88 (mbo) form the cytoplasmic filaments; Gle1 and the Gle1-binding nucleoporin CG18787 (Nucleoporin-like 2) act at this face in the final step of mRNA export.
Annotons
Cytoplasmic filaments
cytoplasmic_filaments_complex
Participant: Protein Complex: Cytoplasmic filaments
Protein Complex:
Part 6: nuclear face
Nuclear basketProtein Complexnuclear_basket
Mgtor (the Tpr homolog), Nup153 and Nup50 form the nuclear basket.
Annotons
Nuclear basket
nuclear_basket_complex
Participant: Protein Complex: Nuclear basket
Protein Complex:
Part 7: peripheral pore components
Peripheral nucleoporinsProtein Complexperipheral_nucleoporins
Rae1, which binds the Gle2-binding sequence of Nup98, and Aladin, which in human cells is anchored to the pore through NDC1.
Annotons
Rae1 Peripheral nucleoporins
peripheral_nucleoporins_rae1
Participant: Gene Product: Rae1
Gene Product:
Rae1UniProtKB:Q9W2E7
Aladin Peripheral nucleoporins
peripheral_nucleoporins_aladin
Participant: Gene Product: Aladin
Gene Product:
AladinUniProtKB:Q9W351