Eukaryotic nuclei contain three multisubunit DNA-directed RNA polymerases. RNA polymerase I transcribes the large ribosomal RNA precursor in the nucleolus, RNA polymerase II transcribes mRNAs and most snRNAs and microRNA precursors, and RNA polymerase III transcribes tRNAs, 5S rRNA, U6 snRNA and other short structured RNAs. Each enzyme has two large catalytic subunits that form the active site, a set of subunits shared by all three enzymes (RPABC1, RPABC2, RPABC3, RPABC4 and RPABC5), subunits shared by Pol I and Pol III (RPAC1 and RPAC2), and enzyme-specific subunits.
Boundary. The common subunits (Polr2E, Polr2F, Polr2H, Polr2K, Polr2L) and the Pol I/III subunits (Polr1C, Polr1D) appear in each enzyme they belong to, following the FlyBase subgroups. Polr2M (Gdown1 homolog) is listed by FlyBase in RNA polymerase II but is an associated factor rather than one of the twelve core subunits. Mitochondrial RNA polymerase and the general transcription factors are outside the module. FlyBase groups realized by this module: RNAP (FBgg0001646). Subgroups folded into it: RNAPII, RNAPI, RNAPIII. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_nuclear_rna_polymerases.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_nuclear_rna_polymerases deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (3 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| rna_polymerase_i_complex | PROTEIN_COMPLEX Gene |
DNA-directed RNA polymerase activity GO:0003899 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| rna_polymerase_ii_complex | PROTEIN_COMPLEX Gene |
DNA-directed RNA polymerase activity GO:0003899 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| rna_polymerase_iii_complex | PROTEIN_COMPLEX Gene |
DNA-directed RNA polymerase activity GO:0003899 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
0 complete review(s) · 0 with deep research · 31 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Polr2E A0A0B4KFB2 | ✗ | — | — |
| Polr3K A1ZBX4 | ✗ | — | — |
| Polr2K A8DYE1 | ✗ | — | — |
| Polr3A A8JUY3 | ✗ | — | — |
| Polr2C O97183 | ✗ | — | — |
| Polr2A P04052 | ✗ | — | — |
| Polr2B P08266 | ✗ | — | — |
| Polr1B P20028 | ✗ | — | — |
| Polr3B P25167 | ✗ | — | — |
| Polr2I P36958 | ✗ | — | — |
| Polr1A P91875 | ✗ | — | — |
| Polr2F Q24320 | ✗ | — | — |
| Polr3D Q7KUR9 | ✗ | — | — |
| Polr3G Q86BI8 | ✗ | — | — |
| Polr1G Q9V493 | ✗ | — | — |
| Polr2L Q9VC49 | ✗ | — | — |
| Polr3F Q9VD25 | ✗ | — | — |
| Polr1H Q9VD81 | ✗ | — | — |
| Polr2M Q9VDY6 | ✗ | — | — |
| Polr1E Q9VE94 | ✗ | — | — |
| Polr2D Q9VEA5 | ✗ | — | — |
| Polr2G Q9VFB5 | ✗ | — | — |
| Polr3C Q9VG60 | ✗ | — | — |
| Polr1D Q9VIZ0 | ✗ | — | — |
| Polr2J Q9VJE4 | ✗ | — | — |
| Polr1F Q9VM72 | ✗ | — | — |
| Polr1C Q9VMX3 | ✗ | — | — |
| Polr2H Q9VNZ3 | ✗ | — | — |
| Polr3E Q9VP85 | ✗ | — | — |
| Polr3H Q9VTL6 | ✗ | — | — |
| Polr3I Q9VX99 | ✗ | — | — |
RNA polymerases I, II and III, which share five common subunits and transcribe rRNA, mRNA and short structured RNAs respectively.