NuRD couples ATP-dependent nucleosome remodeling by the CHD-family ATPase Mi-2 with histone deacetylation by HDAC1 (Rpd3). The deacetylase core also contains the MTA homolog MTA1-like and the histone-binding protein Caf1-55 (p55), and the complex further contains MBD-like, the GATAD2 homolog Simjang and CDK2AP1. NuRD represses transcription, contributes to Polycomb-dependent silencing of Hox genes, and in Drosophila Mi-2 also forms the dMec complex with the zinc-finger protein MEP-1.
The split into remodeler, deacetylase core and MBD/GATAD2 module follows the conserved architecture of mammalian NuRD. MEP-1 is included because FlyBase lists it in the NuRD group; it is best characterised as the partner of Mi-2 in the dMec complex. FlyBase groups realized by this module: NURD (FBgg0000275). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_nurd_complex.yaml. Member genes with a gene review in this repository: Caf1-55.
All recommended fields populated.
✗ none found
No MODULE:dmel_nurd_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| nurd_remodeler_mi_2 | Mi-2 UniProtKB:O97159 Gene |
ATP-dependent chromatin remodeler activity GO:0140658 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| nurd_deacetylase_core_complex/hdac1 | HDAC1 UniProtKB:Q94517 Complex Unit |
histone deacetylase activity GO:0004407 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 1 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| MTA1-like A0A0B4KG70 | ✗ | — | — |
| MBD-like A0A0B4KGZ0 | ✗ | — | — |
| Caf1-55 Q24572 | ✓ | 90/91 | ✓ |
| CDK2AP1 M9PEA2 | ✗ | — | — |
| simj M9PF79 | ✗ | — | — |
| Mi-2 O97159 | ✗ | — | — |
| MEP-1 Q0E8J0 | ✗ | — | — |
| HDAC1 Q94517 | ✗ | — | — |
Mi-2 remodeler and HDAC1 deacetylase complex that represses transcription.
MEP-1 associates with Mi-2 and is also a subunit of the dMec complex.