Two nuclear complexes act in the Drosophila germline piRNA pathway. The Rhino-Deadlock-Cutoff (RDC) complex binds dual-strand piRNA clusters, where the HP1 paralog Rhino recognises H3K9me3, and licenses non-canonical transcription of cluster precursors that are processed into piRNAs. The Panoramix-induced co-transcriptional silencing complex (PICTS, also called SFiNX), made of Panoramix, Nxf2, Nxt1 and dynein light chain Ctp, is recruited by piRNA-guided Piwi to nascent transposon transcripts and triggers H3K9 methylation and heterochromatin formation over the target.
The two FlyBase groups act at different steps (piRNA production versus piRNA-guided silencing) and are linked only through piRNAs and Piwi, which are not modelled here; no direct connection is asserted. Ctp (dynein light chain LC8) also has many cytoplasmic roles; here it is the PICTS dimerising subunit. The module concept is the overall nuclear piRNA heterochromatin pathway that both complexes serve. No molecular function is assigned in this version: the Rhino-Deadlock-Cutoff and Panx-Nxf2-Nxt1-Ctp complexes act as chromatin and RNA adaptors, and the binding terms their subunits carry in GOA (piRNA cluster binding for Cutoff, piRNA binding for Panx, chromatin-protein adaptor activity for Nxf2) are not yet used as annoton functions. FlyBase groups realized by this module: RDC (FBgg0001774), PICTS (FBgg0001963). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_pirna_nuclear_complexes.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_pirna_nuclear_complexes deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 0 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| ctp Q24117 | ✗ | — | — |
| rhi Q7JXA8 | ✗ | — | — |
| Nxt1 Q9V3H8 | ✗ | — | — |
| cuff Q9V629 | ✗ | — | — |
| del Q9VIF5 | ✗ | — | — |
| nxf2 Q9VV73 | ✗ | — | — |
| Panx Q9W2H9 | ✗ | — | — |
RDC, which drives piRNA cluster transcription, and PICTS/SFiNX, which silences piRNA-targeted transposons co-transcriptionally.