The polyol pathway converts glucose to fructose in two steps. An NADPH-dependent aldose reductase of the aldo-keto reductase 1B family reduces glucose to sorbitol, and an NAD+-dependent sorbitol dehydrogenase oxidises sorbitol to fructose. Drosophila has two aldose reductase genes in the FlyBase group (Ar1 and Ar2) and two sorbitol dehydrogenase genes (Sord1 and Sord2).
Ar1 and Ar2 are alternative aldose reductases and Sord1 and Sord2 alternative sorbitol dehydrogenases; each gene is a separate annoton. The aldose reductase activity is given to Ar1, which has been assayed; Ar2 is assigned to the step by FlyBase and sequence similarity only, so no molecular function is given. Ar1 belongs to a family of broad-specificity aldo-keto reductases that also reduce other aldehydes, so its physiological substrates are not limited to glucose. FlyBase groups realized by this module: FRUCBIO (FBgg0002051). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_polyol_pathway.yaml. Member genes with a gene review in this repository: Ar1, Ar2, Sord1, Sord2.
All recommended fields populated.
✗ none found
No MODULE:dmel_polyol_pathway deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
3 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (3 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| aldose_reduction_ar1 | Ar1 UniProtKB:M9PF61 Gene |
aldose reductase (NADPH) activity GO:0004032 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| sorbitol_oxidation_sord1 | Sord1 UniProtKB:O97479 Gene |
L-iditol 2-dehydrogenase (NAD+) activity GO:0003939 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| sorbitol_oxidation_sord2 | Sord2 UniProtKB:O96299 Gene |
L-iditol 2-dehydrogenase (NAD+) activity GO:0003939 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
3 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Ar1 M9PF61 | ✓ | 28/29 | ✓ |
| Ar2 Q9VTY2 | ✓ | ✓ | ✓ |
| Sord1 O97479 | ✓ | ✓ | ✓ |
| Sord2 O96299 | ✓ | ✓ | ✓ |
Two-step conversion of glucose to fructose through sorbitol by aldose reductase and sorbitol dehydrogenase.