The PTW/PP1 complex is a nuclear phosphatase complex made of the PP1-targeting subunit PNUTS, the DNA-binding HMG-box protein Tox4, the WD40 protein Wdr82 and a protein phosphatase 1 catalytic subunit. In other animals it binds chromatin, dephosphorylates RNA polymerase II and transcription elongation factors near the ends of genes and in promoter-proximal regions, and is needed for chromatin reorganization at mitotic exit. Drosophila has four PP1 catalytic subunits (Pp1-87B, Pp1alpha-96A, Pp1-13C and Flapwing, Flw), and FlyBase defines a PTW complex for each.
The four FlyBase PTW-PP1 variants share PNUTS, Tox4 and Wdr82 and differ in the catalytic subunit; they are modelled as one targeting part plus an EXACTLY_ONE catalytic choice. Whether all four PP1 paralogs bind PNUTS in vivo in Drosophila is not established here. Wdr82 is also a subunit of the Set1/COMPASS complex. FlyBase groups realized by this module: PTWP (FBgg0002144). Subgroups folded into it: PTW-FLW, PTW-PP1-13C, PTW-PP1-87B, PTW-PP1ALPHA-96A. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_ptw_pp1_complexes.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_ptw_pp1_complexes deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 4 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| pp1_87b_pp1_87b | Pp1-87B UniProtKB:P12982 Gene |
protein serine/threonine phosphatase activity GO:0004722 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| pp1alpha_96a_pp1alpha_96a | Pp1alpha-96A UniProtKB:P48461 Gene |
protein serine/threonine phosphatase activity GO:0004722 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| pp1_13c_pp1_13c | Pp1-13C UniProtKB:Q05547 Gene |
protein serine/threonine phosphatase activity GO:0004722 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| flw_flw | flw UniProtKB:P48462 Gene |
protein serine/threonine phosphatase activity GO:0004722 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
1 complete review(s) · 1 with deep research · 6 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Pp1-87B P12982 | ✗ | — | — |
| Pp1alpha-96A P48461 | ✗ | — | — |
| flw P48462 | ✗ | — | — |
| Pp1-13C Q05547 | ✗ | — | — |
| PNUTS Q7KU01 | ✗ | — | — |
| Tox4 Q9W0D2 | ✗ | — | — |
| Wdr82 Q9VLN1 | ✓ | ✓ | ✓ |
PNUTS-Tox4-Wdr82 targeting module with one of four PP1 catalytic subunits.