PVR receptor tyrosine kinase signaling in Drosophila melanogaster

PVR is the single Drosophila receptor tyrosine kinase related to vertebrate PDGF and VEGF receptors. It is activated by three secreted ligands, Pvf1, Pvf2 and Pvf3. PVR signaling guides the migration of border cells in the ovary and of other cells during development, and supports the survival, proliferation and migration of embryonic and larval hemocytes, and acts in dorsal closure and thorax closure. Downstream of the receptor, signaling runs through several branches: the Ras-Raf-MEK-ERK cascade, a Crk-Myoblast city-Ced-12 route to the Rac GTPase that drives actin-based migration, a PI3K-Akt-TOR branch that supports growth and survival, and JNK and p38 kinase cascades.

MODULE:dmel_pvr_signalingDRAFTCONCRETESignaling Pathwaymodules/dmel_pvr_signaling.yaml
platelet-derived growth factor receptor signaling pathwayGO:0048008 vascular endothelial growth factor receptor signaling pathwayGO:0048010
FB:FBgg0000972
FlyBase gene group PVR-RTK: Pvr signaling pathway
FlyBase release FB2026_03 groups 41 D. melanogaster genes as pvr signaling pathway (PVR-RTK); this module models that group.
GO:0048008
platelet-derived growth factor receptor signaling pathway
GO term grounding the module as platelet-derived growth factor receptor signaling pathway.
GO:0048010
vascular endothelial growth factor receptor signaling pathway
GO term grounding the module as vascular endothelial growth factor receptor signaling pathway.

Boundary. The downstream branches are shared with many other receptor pathways and are modelled here only as the FlyBase PVR core components. The branches are drawn as parallel outputs of the receptor; which branch is used depends on cell type (Ras-ERK and Rac in migrating cells, PI3K-TOR in hemocyte survival and growth). FlyBase groups realized by this module: PVR-RTK (FBgg0000972). Subgroups folded into it: PVR-C. FlyBase also curates regulator sets for this pathway, which are context and not modelled as parts: PVR-N (negative regulators of pvr signaling pathway, 7 genes); PVR-P (positive regulators of pvr signaling pathway, 1 genes). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_pvr_signaling.yaml. Member genes with a gene review in this repository: Akt, Ced-12, drk, Dsor1, mTor, Raf, Ras85D, rl, Sos.

8Nodes
7Parts
0Variant Sets
0Variants
33Annotons
6Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_pvr_signaling deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

8 gene-function check(s) reflected in core functions · 0 conflict(s) · 8 evidence or coverage gap(s) (16 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
pvr_receptor_pvr Pvr
UniProtKB:E1JHB7
Gene 		transmembrane receptor protein tyrosine kinase activity
GO:0004714 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
ras_erk_branch_sos Sos
UniProtKB:P26675
Gene 		guanyl-nucleotide exchange factor activity
GO:0005085 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
ras_erk_branch_ras85d Ras85D
UniProtKB:P08646
Gene 		GTPase activity
GO:0003924 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
ras_erk_branch_raf Raf
UniProtKB:P11346
Gene 		MAP kinase kinase kinase activity
GO:0004709 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
ras_erk_branch_dsor1 Dsor1
UniProtKB:Q24324
Gene 		MAP kinase kinase activity
GO:0004708 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
ras_erk_branch_rl rl
UniProtKB:P40417
Gene 		MAP kinase activity
GO:0004707 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
ras_erk_branch_aop aop
UniProtKB:Q01842
Gene 		DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001227 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
rac_branch_rac1 Rac1
UniProtKB:P40792
Gene 		GTPase activity
GO:0003924 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
rac_branch_cdc42 Cdc42
UniProtKB:P40793
Gene 		GTPase activity
GO:0003924 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
pi3k_tor_branch_akt Akt
UniProtKB:Q8INB9
Gene 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
pi3k_tor_branch_mtor mTor
UniProtKB:Q9VK45
Gene 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
pi3k_tor_branch_s6k S6k
UniProtKB:Q94533
Gene 		protein serine/threonine kinase activity
GO:0004674 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
stress_mapk_branch_slpr slpr
UniProtKB:Q95UN8
Gene 		MAP kinase kinase kinase activity
GO:0004709 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
stress_mapk_branch_hep hep
UniProtKB:Q23977
Gene 		JUN kinase kinase activity
GO:0008545 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
stress_mapk_branch_bsk bsk
UniProtKB:P92208
Gene 		JUN kinase activity
GO:0004705 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
stress_mapk_branch_lic lic
UniProtKB:O62602
Gene 		MAP kinase kinase activity
GO:0004708 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (11/33 grounded genes reviewed)

4 complete review(s) · 10 with deep research · 22 missing review · 1 reviewed but lacking deep research

Gene Review Complete Deep research
mask A0A0B4K725 ✗ — —
mbc A0A0B4K7Q6 ✗ — —
Pi3K92E A0A0B4KGE8 ✗ — —
Lnk A0A0B4LHY5 ✗ — —
Akt1 Q8INB9 ✓ 94/104 ✓
Cdc42 P40793 ✓ 104/109 ✓
Ced-12 Q9VKB2 ✓ ✓ ✓
drk Q08012 ✓ 74/76 ✓
Dsor1 Q24324 ✓ ✓ ✓
Pvr E1JHB7 ✗ — —
Socs16D M9PHY7 ✗ — —
mTor Q9VK45 ✓ 76/77 ✓
lic O62602 ✗ — —
Rac1 P40792 ✗ — —
bsk P92208 ✗ — —
aop Q01842 ✗ — —
hep Q23977 ✗ — —
ksr Q24171 ✗ — —
S6k Q94533 ✗ — —
slpr Q95UN8 ✗ — —
Vav Q9NHV9 ✗ — —
Shc Q9V3C8 ✗ — —
Pvf3 Q9VM39 ✗ — —
Pvf2 Q9VM43 ✗ — —
PVRAP Q9VRS2 ✗ — —
Pvf1 Q9VWP6 ✗ — —
Crk Q9XYM0 ✗ — —
Thor Q9XZ56 ✗ — —
Raf P11346 ✓ 89/90 ✓
Ras85D P08646 ✓ ✓ ✓
Rheb Q9VND8 ✓ ✓ ✓
rl P40417 ✓ 119/125 ✓
Sos P26675 ✓ 47/50 ✗

Details

Context
Drosophila melanogasterNCBITaxon:7227
PVR signaling pathwaySignaling Pathwaydmel_pvr_signaling

PDGF/VEGF-related receptor tyrosine kinase pathway activated by Pvf1-3 that signals through Ras-ERK, Rac, PI3K-TOR and JNK branches.

platelet-derived growth factor receptor signaling pathwayGO:0048008 vascular endothelial growth factor receptor signaling pathwayGO:0048010
Context
Drosophila melanogasterNCBITaxon:7227

Connections

pvf_ligands -> pvr_receptor Positively Regulates
Pvf ligands bind and activate PVR.
pvr_receptor -> pvr_adaptors Positively Regulates
Phosphorylated PVR recruits phosphotyrosine adaptors.
pvr_adaptors -> ras_erk_branch Positively Regulates
Drk-Sos activates Ras and the ERK cascade.
pvr_receptor -> rac_branch Positively Regulates
PVR activates Rac through Crk and Mbc/Ced-12 during cell migration.
pvr_receptor -> pi3k_tor_branch Positively Regulates
PVR activates PI3K-Akt-TOR signaling.
pvr_receptor -> stress_mapk_branch Positively Regulates
PVR feeds into JNK and p38 kinase cascades in some contexts.
Part 1: secreted ligands
Pvf ligandsSignaling Pathwaypvf_ligands

Annotons

Pvf1 Pvf ligands
pvf_ligands_pvf1
Participant: Gene Product: Pvf1
Gene Product:
Pvf1UniProtKB:Q9VWP6
Pvf2 Pvf ligands
pvf_ligands_pvf2
Participant: Gene Product: Pvf2
Gene Product:
Pvf2UniProtKB:Q9VM43
Pvf3 Pvf ligands
pvf_ligands_pvf3
Participant: Gene Product: Pvf3
Gene Product:
Pvf3UniProtKB:Q9VM39
Part 2: receptor
PVR receptor tyrosine kinaseSignaling Pathwaypvr_receptor

Annotons

Pvr PVR receptor tyrosine kinase
pvr_receptor_pvr
Participant: Gene Product: Pvr
Gene Product:
PvrUniProtKB:E1JHB7

Function

transmembrane receptor protein tyrosine kinase activityGO:0004714
Part 3: phosphotyrosine adaptors and signaling modulators
Receptor-proximal adaptorsSignaling Pathwaypvr_adaptors

Adaptor proteins that FlyBase places at the receptor. Drk (Grb2) and Shc couple the receptor to Sos; PVRAP and Socs16D are further FlyBase core members whose precise position in the pathway is less well defined.

Annotons

drk Receptor-proximal adaptors
pvr_adaptors_drk
Participant: Gene Product: drk
Gene Product:
drkUniProtKB:Q08012
Shc Receptor-proximal adaptors
pvr_adaptors_shc
Participant: Gene Product: Shc
Gene Product:
ShcUniProtKB:Q9V3C8
PVRAP Receptor-proximal adaptors
pvr_adaptors_pvrap
Participant: Gene Product: PVRAP
Gene Product:
PVRAPUniProtKB:Q9VRS2
Socs16D Receptor-proximal adaptors
pvr_adaptors_socs16d
Participant: Gene Product: Socs16D
Gene Product:
Socs16DUniProtKB:M9PHY7
Part 4: Ras-MAPK cascade
Ras-ERK branchSignaling Pathwayras_erk_branch

Annotons

Sos Ras-ERK branch
ras_erk_branch_sos
Participant: Gene Product: Sos
Gene Product:
SosUniProtKB:P26675

Function

guanyl-nucleotide exchange factor activityGO:0005085

Processes

MAPK cascadeGO:0000165
Ras85D Ras-ERK branch
ras_erk_branch_ras85d
Participant: Gene Product: Ras85D
Gene Product:
Ras85DUniProtKB:P08646

Function

GTPase activityGO:0003924

Processes

MAPK cascadeGO:0000165
Raf Ras-ERK branch
ras_erk_branch_raf
Participant: Gene Product: Raf
Gene Product:
RafUniProtKB:P11346

Function

MAP kinase kinase kinase activityGO:0004709

Processes

MAPK cascadeGO:0000165
ksr Ras-ERK branch
ras_erk_branch_ksr
Participant: Gene Product: ksr
Gene Product:
ksrUniProtKB:Q24171

Processes

MAPK cascadeGO:0000165
Dsor1 Ras-ERK branch
ras_erk_branch_dsor1
Participant: Gene Product: Dsor1
Gene Product:
Dsor1UniProtKB:Q24324

Function

MAP kinase kinase activityGO:0004708

Processes

MAPK cascadeGO:0000165
aop Ras-ERK branch
ras_erk_branch_aop
Participant: Gene Product: aop
Gene Product:
aopUniProtKB:Q01842

Function

DNA-binding transcription repressor activity, RNA polymerase II-specificGO:0001227

Processes

MAPK cascadeGO:0000165
Part 5: Rac activation for cell migration
Crk-Mbc-Ced-12 Rac branchSignaling Pathwayrac_branch

Crk links the receptor to the bipartite Rac exchange factor Myoblast city/Ced-12 (DOCK180/ELMO); Vav is a further Rac/Cdc42 exchange factor.

Annotons

Crk Crk-Mbc-Ced-12 Rac branch
rac_branch_crk
Participant: Gene Product: Crk
Gene Product:
CrkUniProtKB:Q9XYM0
mbc Crk-Mbc-Ced-12 Rac branch
rac_branch_mbc
Participant: Gene Product: mbc
Gene Product:
mbcUniProtKB:A0A0B4K7Q6
Ced-12 Crk-Mbc-Ced-12 Rac branch
rac_branch_ced_12
Participant: Gene Product: Ced-12
Gene Product:
Ced-12UniProtKB:Q9VKB2
Vav Crk-Mbc-Ced-12 Rac branch
rac_branch_vav
Participant: Gene Product: Vav
Gene Product:
VavUniProtKB:Q9NHV9
Rac1 Crk-Mbc-Ced-12 Rac branch
rac_branch_rac1
Participant: Gene Product: Rac1
Gene Product:
Rac1UniProtKB:P40792

Function

GTPase activityGO:0003924
Cdc42 Crk-Mbc-Ced-12 Rac branch
rac_branch_cdc42
Participant: Gene Product: Cdc42
Gene Product:
Cdc42UniProtKB:P40793

Function

GTPase activityGO:0003924
Part 6: growth and survival signaling
PI3K-Akt-TOR branchSignaling Pathwaypi3k_tor_branch

Annotons

Lnk PI3K-Akt-TOR branch
pi3k_tor_branch_lnk
Participant: Gene Product: Lnk
Gene Product:
LnkUniProtKB:A0A0B4LHY5
Pi3K92E PI3K-Akt-TOR branch
pi3k_tor_branch_pi3k92e
Participant: Gene Product: Pi3K92E
Gene Product:
Pi3K92EUniProtKB:A0A0B4KGE8
Akt PI3K-Akt-TOR branch
pi3k_tor_branch_akt
Participant: Gene Product: Akt
Gene Product:
AktUniProtKB:Q8INB9

Function

protein serine/threonine kinase activityGO:0004674
Rheb PI3K-Akt-TOR branch
pi3k_tor_branch_rheb
Participant: Gene Product: Rheb
Gene Product:
RhebUniProtKB:Q9VND8
mTor PI3K-Akt-TOR branch
pi3k_tor_branch_mtor
Participant: Gene Product: mTor
Gene Product:
mTorUniProtKB:Q9VK45

Function

protein serine/threonine kinase activityGO:0004674
S6k PI3K-Akt-TOR branch
pi3k_tor_branch_s6k
Participant: Gene Product: S6k
Gene Product:
S6kUniProtKB:Q94533

Function

protein serine/threonine kinase activityGO:0004674
Thor PI3K-Akt-TOR branch
pi3k_tor_branch_thor
Participant: Gene Product: Thor
Gene Product:
ThorUniProtKB:Q9XZ56
Part 7: stress-activated MAPK cascades
JNK and p38 kinase branchesSignaling Pathwaystress_mapk_branch

Annotons

slpr JNK and p38 kinase branches
stress_mapk_branch_slpr
Participant: Gene Product: slpr
Gene Product:
slprUniProtKB:Q95UN8

Function

MAP kinase kinase kinase activityGO:0004709
hep JNK and p38 kinase branches
stress_mapk_branch_hep
Participant: Gene Product: hep
Gene Product:
hepUniProtKB:Q23977

Function

JUN kinase kinase activityGO:0008545
bsk JNK and p38 kinase branches
stress_mapk_branch_bsk
Participant: Gene Product: bsk
Gene Product:
bskUniProtKB:P92208

Function

JUN kinase activityGO:0004705
lic JNK and p38 kinase branches
stress_mapk_branch_lic
Participant: Gene Product: lic
Gene Product:
licUniProtKB:O62602

Function

MAP kinase kinase activityGO:0004708