Partner of Inscuteable (Pins, also called Raps) and Inscuteable (Insc) form a complex at the apical cortex of dividing neuroblasts. Insc binds the Par complex through Bazooka and recruits Pins, which with the G protein alpha subunit Galphai binds Mud (NuMA) and orients the mitotic spindle along the apical-basal axis. This coupling of cell polarity to spindle orientation ensures that basal cell-fate determinants segregate into the smaller ganglion mother cell during asymmetric neuroblast division.
Galphai, Mud and Bazooka bind the complex but are not members of the FlyBase group and are treated as context. Pins is also active in epithelia without Insc. Insc is given cytoskeletal adaptor activity (GO:0008093; GOA IMP, IBA) and Pins, whose GoLoco motifs bind GDP-Galphai, GDP-dissociation inhibitor activity (GO:0005092; GOA IBA). FlyBase groups realized by this module: RIC (FBgg0001988). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_raps_insc_complex.yaml. Member genes with a gene review in this repository: insc, pins.
All recommended fields populated.
✗ none found
No MODULE:dmel_raps_insc_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| inscuteable_insc | insc UniProtKB:Q9W2R4 Gene |
cytoskeletal adaptor activity GO:0008093 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| pins_pins | pins UniProtKB:Q9VB22 Gene |
GDP-dissociation inhibitor activity GO:0005092 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| insc Q9W2R4 | ✓ | ✓ | ✓ |
| pins Q9VB22 | ✓ | ✓ | ✓ |
Insc-Pins complex that links the apical Par complex to spindle orientation in asymmetrically dividing neuroblasts.