The complexes of the mitochondrial oxidative phosphorylation system are built from nuclear- and mitochondrially encoded subunits with the help of dedicated assembly factors that are not part of the mature enzymes. Complex II (succinate dehydrogenase) assembly factors include SDHAF2-type proteins required for covalent flavinylation of the SdhA subunit and SDHAF3 and SDHAF4 homologs that protect the iron-sulfur subunit and intermediates. Complex III assembly requires the AAA ATPase Bcs1, which inserts the Rieske iron-sulfur protein, the LYR protein LYRM7 that chaperones it, and the UQCC proteins that support cytochrome b. HIG1 domain proteins associate with complexes III and IV and support respiratory supercomplex formation. ATP synthase (complex V) assembly factors include ATPAF1-type chaperones of the F1 domain, TMEM70 and the metalloprotease ATP23.
The module groups four FlyBase assembly-factor sets; the factors act on different complexes and are not a single complex or a linear pathway, so no connections are asserted. Complex I and complex IV assembly factors are not in these FlyBase groups and are outside this module. Several members are uncharacterised in Drosophila (for example CG15386, CG30373, CG17734 and CG12107) and are included on the strength of FlyBase group membership and orthology; process terms are applied at the level of each group and do not imply that each member has been tested. Molecular functions are left unset because they are not established for the Drosophila proteins. FlyBase groups realized by this module: MCIII-AF (FBgg0002034), MCR-AF (FBgg0002036), MCII-AF (FBgg0002037), MCV-AF (FBgg0002039). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_respiratory_complex_assembly_factors.yaml. Member genes with a gene review in this repository: CG34117.
All recommended fields populated.
✗ none found
No MODULE:dmel_respiratory_complex_assembly_factors deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
0 complete review(s) · 1 with deep research · 23 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| CG17734 A0A0B4K6E6 | ✗ | — | — |
| CG11825 A0A0B4KEI1 | ✗ | — | — |
| CG46459 A0A6H2EGA2 | ✗ | — | — |
| CG12107 A1Z733 | ✗ | — | — |
| CG30373 A1Z7B8 | ✗ | — | — |
| CG12895 A1Z897 | ✗ | — | — |
| sloth2 B7Z0X7 | ✗ | — | — |
| CG34117 Q0KI97 | ✓ | 4/5 | ✓ |
| CG34150 Q0KI15 | ✗ | — | — |
| CG14757 Q4V5I9 | ✗ | — | — |
| Ttc19 Q8SYD0 | ✗ | — | — |
| Sdhaf3 Q8SZ16 | ✗ | — | — |
| Tmem70 Q95SS8 | ✗ | — | — |
| CG10340 Q9VES8 | ✗ | — | — |
| l(2)k14505 Q9VID7 | ✗ | — | — |
| CG5131 Q9VJD0 | ✗ | — | — |
| CG15283 Q9VJS6 | ✗ | — | — |
| Bcs1 Q9VL22 | ✗ | — | — |
| Sirup Q9VLU6 | ✗ | — | — |
| CG15386 Q9VQ88 | ✗ | — | — |
| Uqcc1 Q9VRZ7 | ✗ | — | — |
| CG9921 Q9VXH4 | ✗ | — | — |
| CG11699 Q9VYX5 | ✗ | — | — |
| sloth1 Q9W3T5 | ✗ | — | — |
Non-subunit chaperones and assembly factors needed to build respiratory complexes II and III, respiratory supercomplexes and ATP synthase.