Retromer retrieves transmembrane cargo from endosomes and returns it to the trans-Golgi network or to the plasma membrane. Its cargo-selective core is a heterotrimer of Vps35, Vps26 and Vps29 that recognizes sorting motifs in cargo tails; it associates with sorting nexins, including the SNX-BAR proteins Snx1 and Snx6, which bind endosomal phosphoinositides and shape membrane tubules. In Drosophila, retromer recycles the Wnt cargo receptor Wntless (Wls) to the Golgi, which is needed for Wingless secretion, and it also maintains rhodopsin and other cargo in photoreceptors.
Decomposition. The cargo-selective trimer and the SNX-BAR sorting nexin pair are modelled as separate parts; the SNX-BAR proteins associate with the trimer less stably than the trimer subunits associate with each other. Snx3 and the WASH complex, which also cooperate with retromer, are outside this module. The cargo-selective trimer is given cargo adaptor activity (GO:0140312) at complex level; Vps35 and Vps29 carry this term in GOA by IBA, and Vps35 and Vps26 carry cargo receptor activity by IPI. The SNX-BAR pair carries only phosphoinositide-binding terms and has no annoton function. FlyBase groups realized by this module: RETRO (FBgg0000196). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_retromer.yaml. Member genes with a gene review in this repository: Snx1, Snx6, Vps26, Vps29, Vps35.
All recommended fields populated.
✗ none found
No MODULE:dmel_retromer deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| cargo_selective_complex_complex | PROTEIN_COMPLEX Gene |
cargo adaptor activity GO:0140312 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
5 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Snx1 Q9VQQ6 | ✓ | ✓ | ✓ |
| Snx6 M9NDI3 | ✓ | ✓ | ✓ |
| Vps26 Q9W552 | ✓ | ✓ | ✓ |
| Vps29 Q9VPX5 | ✓ | ✓ | ✓ |
| Vps35 Q9W277 | ✓ | ✓ | ✓ |
Vps35-Vps26-Vps29 cargo-selective complex with SNX-BAR sorting nexins that retrieves cargo from endosomes to the Golgi and plasma membrane.