Ribonucleotide reductase in Drosophila melanogaster

Class I ribonucleotide reductase converts ribonucleoside diphosphates to deoxyribonucleoside diphosphates, the rate-limiting step in supplying dNTPs for DNA replication and repair. It is a complex of a large R1 subunit (RnrL), which contains the catalytic site and the allosteric sites that control activity and substrate specificity, and a small R2 subunit (RnrS), which carries the diferric-tyrosyl radical cofactor that starts catalysis. Electrons are supplied by thioredoxin or glutaredoxin.

MODULE:dmel_ribonucleotide_reductaseDRAFTCONCRETEProtein Complexmodules/dmel_ribonucleotide_reductase.yaml
ribonucleoside-diphosphate reductase complexGO:0005971
FB:FBgg0002006
FlyBase gene group RNRC: Ribonucleotide reductase complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as ribonucleotide reductase complex (RNRC); this module models that group.
GO:0005971
ribonucleoside-diphosphate reductase complex
GO term grounding the module as ribonucleoside-diphosphate reductase complex.

The reductase activity is assigned to the catalytic R1 subunit; R2 provides the tyrosyl radical. Thioredoxins and dNTP-pool regulators are outside the module. FlyBase groups realized by this module: RNRC (FBgg0002006). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_ribonucleotide_reductase.yaml. Member genes with a gene review in this repository: RnrL, RnrS.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_ribonucleotide_reductase deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_ribonucleotide_reductase_rnrl_rnrl RnrL
UniProtKB:P48591
Gene 		ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0004748 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
RnrL P48591 ✓ ✓ ✓
RnrS P48592 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
cytosolGO:0005829
Ribonucleotide reductaseProtein Complexdmel_ribonucleotide_reductase

R1-R2 ribonucleotide reductase that makes deoxyribonucleotides for DNA synthesis.

ribonucleoside-diphosphate reductase complexGO:0005971
Context
Drosophila melanogasterNCBITaxon:7227
cytosolGO:0005829
Part 1: R1 catalytic and allosteric subunit
RnrLModuledmel_ribonucleotide_reductase_rnrl

Annotons

RnrL subunit
dmel_ribonucleotide_reductase_rnrl_rnrl
Participant: Gene Product: RnrL
Gene Product:
RnrLUniProtKB:P48591

Function

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorGO:0004748

R1 catalytic and allosteric subunit

Part 2: R2 radical-generating subunit
RnrSModuledmel_ribonucleotide_reductase_rnrs

Annotons

RnrS subunit
dmel_ribonucleotide_reductase_rnrs_rnrs
Participant: Gene Product: RnrS
Gene Product:
RnrSUniProtKB:P48592

R2 radical-generating subunit