Exosome nine-subunit core
exosome_core_complex
Participant: Protein Complex: Exosome nine-subunit core
Protein Complex:
RNA exosome and nuclear exosome targeting complex in Drosophila melanogaster
The RNA exosome is a 3'-5' exoribonuclease complex that processes and degrades many classes of RNA in the nucleus and cytoplasm. A catalytically inactive nine-subunit barrel, made of a six-subunit ring (including Ski6, Mtr3, Rrp42, Rrp45 and Rrp46) capped by Csl4, Rrp4 and Rrp40, channels RNA to the processive exonuclease and endonuclease Dis3 (Rrp44). The nuclear exosome also contains the distributive exonuclease Rrp6. Nuclear cofactors deliver substrates: the nuclear exosome targeting (NEXT) complex, formed by the RNA helicase Mtr4, a zinc-knuckle protein (CG4622, ZCCHC8 homolog) and an RRM protein (CG11454, RBM7 homolog), targets short-lived non-polyadenylated transcripts for decay.
exosome (RNase complex)GO:0000178
FB:FBgg0001939
FlyBase gene group RNAEXO: Rna exosome complexes
FlyBase release FB2026_03 groups 10 D. melanogaster genes as rna exosome complexes (RNAEXO); this module models that group.
FB:FBgg0002165
FlyBase gene group NEXT: Nuclear exosome targeting complex
FlyBase release FB2026_03 groups 3 D. melanogaster genes as nuclear exosome targeting complex (NEXT); this module models that group.
Boundary. FlyBase groups the nuclear exosome (RNA-EXO, with Rrp6) and the cytoplasmic exosome (RNA-EXOC, without Rrp6); both are captured by the shared core and nuclease parts, with Rrp6's nuclear restriction noted. The Ski complex, TRAMP and other cytoplasmic and nuclear cofactors have no FlyBase group here and are not added. FlyBase groups realized by this module: RNAEXO (FBgg0001939), NEXT (FBgg0002165). Subgroups folded into it: RNA-EXO, RNA-EXOC. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_rna_exosome.yaml. None of the member genes has a gene review in this repository yet.
4Nodes
3Parts
0Variant Sets
0Variants
4Annotons
1Connections
Derived QC
Recommended-field compliance
100.0%
recommended fields populated
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_rna_exosome deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 3 evidence or coverage gap(s) (3 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| exosome_nucleases_dis3 | Dis3 UniProtKB:Q9VC93 Gene |
3'-5'-RNA exonuclease activity GO:0000175 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| exosome_nucleases_rrp6 | Rrp6 UniProtKB:Q9VFF3 Gene |
3'-5'-RNA exonuclease activity GO:0000175 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| next_complex_complex/mtr4 | Mtr4 UniProtKB:Q9Y134 Complex Unit |
RNA helicase activity GO:0003724 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
Gene-review completeness (0/13 grounded genes reviewed)
0 complete review(s) · 0 with deep research · 13 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Rrp42 A1ZA82 | ✗ | — | — |
| CG4622 Q2PE14 | ✗ | — | — |
| Rrp45 Q7KUX6 | ✗ | — | — |
| Rrp40 Q8IPX7 | ✗ | — | — |
| Dis3 Q9VC93 | ✗ | — | — |
| Rrp6 Q9VFF3 | ✗ | — | — |
| Rrp46 Q9VGZ2 | ✗ | — | — |
| Ski6 Q9VK19 | ✗ | — | — |
| Csl4 Q9VKJ4 | ✗ | — | — |
| CG11454 Q9VPK4 | ✗ | — | — |
| Mtr3 Q9VW53 | ✗ | — | — |
| Rrp4 Q9W1M9 | ✗ | — | — |
| Mtr4 Q9Y134 | ✗ | — | — |
Details
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
cytoplasmGO:0005737
RNA exosomeProtein Complexdmel_rna_exosome
Nine-subunit exosome barrel with Dis3 and Rrp6 exonucleases, and the NEXT complex that targets nuclear transcripts to it.
exosome (RNase complex)GO:0000178
Context
Drosophila melanogasterNCBITaxon:7227
nucleusGO:0005634
cytoplasmGO:0005737
Connections
NEXT unwinds and delivers nuclear RNA substrates to the exosome.
Part 1: RNA-channelling barrel
Exosome nine-subunit coreProtein Complexexosome_core
Annotons
Part 2: catalytic subunits
Exosome-associated ribonucleasesProtein Complexexosome_nucleases
Dis3 is present in both nuclear and cytoplasmic exosomes; Rrp6 is nuclear.
Annotons
Dis3 Exosome-associated ribonucleases
exosome_nucleases_dis3
Participant: Gene Product: Dis3
Gene Product:
Dis3UniProtKB:Q9VC93
Function
3'-5'-RNA exonuclease activityGO:0000175
Rrp6 Exosome-associated ribonucleases
exosome_nucleases_rrp6
Participant: Gene Product: Rrp6
Gene Product:
Rrp6UniProtKB:Q9VFF3
Function
3'-5'-RNA exonuclease activityGO:0000175
Part 3: nuclear substrate delivery
Nuclear exosome targeting complexProtein Complexnext_complex
Annotons
Nuclear exosome targeting complex
next_complex_complex
Participant: Protein Complex: Nuclear exosome targeting complex
Protein Complex:
Nuclear exosome targeting complexGO:0062141
Active units:
Mtr4
Participant: Gene Product: Mtr4
Gene Product:
Mtr4UniProtKB:Q9Y134
Function:
RNA helicase activityGO:0003724
Processes
nuclear RNA surveillanceGO:0071027