The RZZ complex, made of Rough deal (Rod), Zw10 and Zwilch, assembles on unattached kinetochores in prometaphase. It recruits the Mad1-Mad2 checkpoint proteins and is therefore required for the spindle assembly checkpoint, and it recruits dynein-dynactin through the adaptor Spindly. Once microtubules attach, dynein strips RZZ and checkpoint proteins from the kinetochore along kinetochore fibres, which helps silence the checkpoint. Rod and Zw10 were first identified in Drosophila through mutants with chromosome segregation defects.
Spindly, dynein-dynactin and Mad1-Mad2 are partners outside the module. Each subunit is modelled as a part. Zw10 is given kinetochore adaptor activity (GO:0140483), which it carries in GOA by IBA; Rod and Zwilch carry no informative molecular function term and have none here. FlyBase groups realized by this module: RZZ (FBgg0000096). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_rzz_complex.yaml. Member genes with a gene review in this repository: rod, Zw10, Zwilch.
All recommended fields populated.
✗ none found
No MODULE:dmel_rzz_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| dmel_rzz_complex_zw10_zw10 | Zw10 UniProtKB:Q9W4X9 Gene |
kinetochore adaptor activity GO:0140483 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
3 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| rod Q9V9W7 | ✓ | ✓ | ✓ |
| Zw10 Q9W4X9 | ✓ | ✓ | ✓ |
| Zwilch Q9VA00 | ✓ | ✓ | ✓ |
Rod-Zw10-Zwilch kinetochore complex that recruits Mad1-Mad2 and dynein for spindle checkpoint signalling.
Zw10 subunit
Zwilch subunit
Rod (Rough deal) subunit