At the end of the third larval instar, the larval salivary glands make large amounts of glue glycoproteins in response to the ecdysone pulse, store them in secretory granules and release them into the gland lumen. At pupariation the larva expectorates the glue, which spreads over the body and hardens, fixing the puparium to the substrate for metamorphosis. The glue is a mixture of unrelated proteins: long, repeat-rich, heavily glycosylated mucin-like proteins (Sgs1, Sgs3, Sgs4 and the mucin Eig71Ee/gp150), small cysteine-rich proteins (Sgs7, Sgs8) and Sgs5 and Sgs5bis, whose role in the glue is not known.
Boundary. The module contains the glue proteins themselves. Glue granule biogenesis and exocytosis (for example Swip-1, which promotes glue granule exocytosis) and the ecdysone-triggered transcriptional program are upstream context, not parts. Most bioadhesive activity annotations rest on the 1976 biochemical characterization of the glue (PMID:825230). FlyBase groups realized by this module: GLUE (FBgg0001189). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_salivary_glue_secretion.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_salivary_glue_secretion deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| mucin_like_glue_proteins_sgs1 | Sgs1 UniProtKB:Q9VR49 Gene |
bioadhesive activity GO:0140073 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| mucin_like_glue_proteins_sgs3 | Sgs3 UniProtKB:P02840 Gene |
bioadhesive activity GO:0140073 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| mucin_like_glue_proteins_sgs4 | Sgs4 UniProtKB:Q00725 Gene |
bioadhesive activity GO:0140073 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| small_cysteine_rich_glue_proteins_sgs7 | Sgs7 UniProtKB:P02841 Gene |
bioadhesive activity GO:0140073 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| small_cysteine_rich_glue_proteins_sgs8 | Sgs8 UniProtKB:P02842 Gene |
bioadhesive activity GO:0140073 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 8 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Sgs3 P02840 | ✗ | — | — |
| Sgs7 P02841 | ✗ | — | — |
| Sgs8 P02842 | ✗ | — | — |
| Sgs5 P07701 | ✗ | — | — |
| Sgs4 Q00725 | ✗ | — | — |
| Sgs5bis Q9VEI6 | ✗ | — | — |
| Sgs1 Q9VR49 | ✗ | — | — |
| Eig71Ee Q9VUS8 | ✗ | — | — |
Salivary glue proteins expectorated at pupariation that attach the puparium to the substrate.
Long glue proteins with internal repeats and heavy O-glycosylation. Eig71Ee (gp150) is also expressed in hemocytes and takes part in hemolymph clotting.
Short cysteine-rich glue proteins encoded by the paired Sgs7 and Sgs8 genes.
Sgs5 and its paralog Sgs5bis lack the long glycosylated repeats of Sgs1, Sgs3 and Sgs4; their contribution to adhesion is untested.