SCF-Slimb ubiquitin ligase in Drosophila melanogaster

SCF-Slimb is a cullin-RING E3 ubiquitin ligase in which the F-box protein Supernumerary limbs (Slimb, the beta-TrCP ortholog) recognizes phosphorylated degron motifs and the Cul1-Roc1a core transfers ubiquitin to the bound substrate. SkpA bridges the F-box of Slimb to Cul1. Slimb targets include Armadillo in Wingless signalling, Cubitus interruptus in Hedgehog signalling, the centriole duplication kinase Plk4 and the clock protein Period, so SCF-Slimb restrains several signalling pathways and centriole number.

MODULE:dmel_scf_slimb_ubiquitin_ligaseDRAFTCONCRETEProtein Complexmodules/dmel_scf_slimb_ubiquitin_ligase.yaml
SCF ubiquitin ligase complexGO:0019005
FB:FBgg0000894
FlyBase gene group SCF-SLMB: Scf-slmb ubiquitin ligase complex
FlyBase release FB2026_03 groups 4 D. melanogaster genes as scf-slmb ubiquitin ligase complex (SCF-SLMB); this module models that group.
GO:0019005
SCF ubiquitin ligase complex
GO term grounding the module as SCF ubiquitin ligase complex.

Cul1, Roc1a and SkpA are shared with other SCF ligases; Slimb defines this module. Substrates and the kinases that create phosphodegrons are outside the module. FlyBase groups realized by this module: SCF-SLMB (FBgg0000894). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_scf_slimb_ubiquitin_ligase.yaml. Member genes with a gene review in this repository: Cul1, Roc1a, SkpA, slmb.

4Nodes
3Parts
0Variant Sets
0Variants
3Annotons
1Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_scf_slimb_ubiquitin_ligase deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
cul1_roc1a_core_complex PROTEIN_COMPLEX
Gene 		ubiquitin protein ligase activity
GO:0061630 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.

Gene-review completeness (4/4 grounded genes reviewed)

3 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Cul1 Q24311 ✓ ✓ ✓
Roc1a Q9W5E1 ✓ ✓ ✓
SkpA O77430 ✓ ✓ ✓
slmb A0A0B4KHK1 ✓ 83/84 ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
SCF-Slimb ubiquitin ligaseProtein Complexdmel_scf_slimb_ubiquitin_ligase

Cul1-Roc1a-SkpA cullin-RING ligase with the F-box substrate receptor Slimb (beta-TrCP).

SCF ubiquitin ligase complexGO:0019005
Context
Drosophila melanogasterNCBITaxon:7227

Connections

slimb_receptor -> cul1_roc1a_core Provides Input For
Slimb delivers phosphodegron-bearing substrates to the catalytic core via SkpA.
Part 1: cullin-RING catalytic core
Cul1-Roc1a catalytic coreProtein Complexcul1_roc1a_core

Annotons

Cul1-Roc1a catalytic core
cul1_roc1a_core_complex
Participant: Protein Complex: Cul1-Roc1a catalytic core
Protein Complex:
Cul1-Roc1a catalytic core
Active units:
Cul1
Participant: Gene Product: Cul1
Gene Product:
Cul1UniProtKB:Q24311
Roc1a
Participant: Gene Product: Roc1a
Gene Product:
Roc1aUniProtKB:Q9W5E1

Function

ubiquitin protein ligase activityGO:0061630
Part 2: F-box adaptor
SkpA adaptorProtein Complexskpa_adaptor

Annotons

SkpA SkpA adaptor
skpa_adaptor_skpa
Participant: Gene Product: SkpA
Gene Product:
SkpAUniProtKB:O77430
Part 3: F-box substrate receptor
Slimb substrate receptorProtein Complexslimb_receptor

Annotons

slmb Slimb substrate receptor
slimb_receptor_slmb
Participant: Gene Product: slmb
Gene Product:
slmbUniProtKB:A0A0B4KHK1