Sec61 translocon and associated complexes in Drosophila melanogaster

The Sec61 complex is the protein-conducting channel of the endoplasmic reticulum membrane. Its alpha subunit forms an hourglass-shaped pore with a lateral gate through which signal sequences and transmembrane segments of nascent polypeptides enter the lipid bilayer; the small beta and gamma subunits stabilize the channel. Sec61 receives ribosome-nascent chain complexes from the SRP receptor for cotranslational translocation, and with the Sec62-Sec63 complex it also translocates proteins post-translationally. Translocon-associated proteins such as TRAM and the TRAP complex assist the insertion and translocation of particular substrates. Drosophila has three Sec61 gamma genes, Sec61gamma, CG8860 and the testis-expressed CG13426, giving alternative forms of the channel.

MODULE:dmel_sec61_transloconDRAFTCONCRETEProtein Complexmodules/dmel_sec61_translocon.yaml
translocon complexGO:0071256
FB:FBgg0001851
FlyBase gene group SEC61TC: Sec61 translocon complexes
FlyBase release FB2026_03 groups 5 D. melanogaster genes as sec61 translocon complexes (SEC61TC); this module models that group.
FB:FBgg0001902
FlyBase gene group SEC-PF: General secretory pathway complexes
FlyBase release FB2026_03 groups 7 D. melanogaster genes as general secretory pathway complexes (SEC-PF); this module models that group.
FB:FBgg0001920
FlyBase gene group SEC62-63: Sec62/sec63 complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as sec62/sec63 complex (SEC62-63); this module models that group.
FB:FBgg0001921
FlyBase gene group SEC-T: Endoplasmic reticulum sec translocon complexes
FlyBase release FB2026_03 groups 7 D. melanogaster genes as endoplasmic reticulum sec translocon complexes (SEC-T); this module models that group.
FB:FBgg0001922
FlyBase gene group SEC-TRAP: Sec61 translocon-associated proteins
FlyBase release FB2026_03 groups 2 D. melanogaster genes as sec61 translocon-associated proteins (SEC-TRAP); this module models that group.
GO:0071256
translocon complex
GO term grounding the module as translocon complex.

Decomposition. The Sec61 heterotrimer is modelled as three variants that differ in their gamma subunit, following FlyBase. FlyBase groups only TRAM and Tapdelta as translocon-associated proteins; they are modelled as individual proteins and the other TRAP subunits are not added. SRP targeting is the separate module dmel_srp_cotranslational_targeting; signal peptidase and oligosaccharyltransferase are outside this module. FlyBase groups realized by this module: SEC61TC (FBgg0001851), SEC-PF (FBgg0001902), SEC62-63 (FBgg0001920), SEC-T (FBgg0001921), SEC-TRAP (FBgg0001922). Subgroups folded into it: SEC61T-CG8860, SEC61T-G2, SEC61T-T. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_sec61_translocon.yaml. None of the member genes has a gene review in this repository yet.

7Nodes
3Parts
1Variant Sets
3Variants
6Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_sec61_translocon deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 3 evidence or coverage gap(s) (3 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
sec61_sec61gamma_complex/sec61alpha Sec61alpha
UniProtKB:X2J771
Complex Unit 		transmembrane protein transporter activity
GO:0008320 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
sec61_cg8860_complex/sec61alpha Sec61alpha
UniProtKB:X2J771
Complex Unit 		transmembrane protein transporter activity
GO:0008320 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
sec61_testis_complex/sec61alpha Sec61alpha
UniProtKB:X2J771
Complex Unit 		transmembrane protein transporter activity
GO:0008320 		Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (0/9 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 9 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Tapdelta A0A0B4LF68 ✗ — —
Sec61beta A1Z9S7 ✗ — —
CG13426 A1ZBU4 ✗ — —
CG8860 Q9V668 ✗ — —
Trp1 Q9VL49 ✗ — —
Sec63 Q9VS57 ✗ — —
Sec61gamma Q9VWE9 ✗ — —
TRAM Q9W5C2 ✗ — —
Sec61alpha X2J771 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
endoplasmic reticulum membraneGO:0005789
Sec61 transloconProtein Complexdmel_sec61_translocon

Sec61 protein-conducting channel with its gamma-subunit variants, the Sec62-Sec63 post-translational translocation complex and translocon-associated proteins.

translocon complexGO:0071256
Context
Drosophila melanogasterNCBITaxon:7227
endoplasmic reticulum membraneGO:0005789
Part 1: protein-conducting channel
Sec61 channelProtein Complexsec61_channel
Variant set: Sec61 complexes with alternative gamma subunits (One Or More)
Sec61 complex with Sec61gammaProtein Complexsec61_sec61gamma

Annotons

Sec61 complex with Sec61gamma
sec61_sec61gamma_complex
Participant: Protein Complex: Sec61 complex with Sec61gamma
Protein Complex:
Sec61 complex with Sec61gammaGO:0005784
Active units:
Sec61alpha
Participant: Gene Product: Sec61alpha
Gene Product:
Sec61alphaUniProtKB:X2J771
Function:
transmembrane protein transporter activityGO:0008320
Sec61beta
Participant: Gene Product: Sec61beta
Gene Product:
Sec61betaUniProtKB:A1Z9S7
Sec61gamma
Participant: Gene Product: Sec61gamma
Gene Product:
Sec61gammaUniProtKB:Q9VWE9

Processes

SRP-dependent cotranslational protein targeting to membrane, translocationGO:0006616
Sec61 complex with CG8860 gamma subunitProtein Complexsec61_cg8860

Annotons

Sec61 complex with CG8860 gamma subunit
sec61_cg8860_complex
Participant: Protein Complex: Sec61 complex with CG8860 gamma subunit
Protein Complex:
Sec61 complex with CG8860 gamma subunitGO:0005784
Active units:
CG8860
Participant: Gene Product: CG8860
Gene Product:
CG8860UniProtKB:Q9V668
Sec61alpha
Participant: Gene Product: Sec61alpha
Gene Product:
Sec61alphaUniProtKB:X2J771
Function:
transmembrane protein transporter activityGO:0008320
Sec61beta
Participant: Gene Product: Sec61beta
Gene Product:
Sec61betaUniProtKB:A1Z9S7

Processes

SRP-dependent cotranslational protein targeting to membrane, translocationGO:0006616
Testis-specific Sec61 complex with CG13426Protein Complexsec61_testis

Annotons

Testis-specific Sec61 complex with CG13426
sec61_testis_complex
Participant: Protein Complex: Testis-specific Sec61 complex with CG13426
Protein Complex:
Testis-specific Sec61 complex with CG13426GO:0005784
Active units:
CG13426
Participant: Gene Product: CG13426
Gene Product:
CG13426UniProtKB:A1ZBU4
Sec61alpha
Participant: Gene Product: Sec61alpha
Gene Product:
Sec61alphaUniProtKB:X2J771
Function:
transmembrane protein transporter activityGO:0008320
Sec61beta
Participant: Gene Product: Sec61beta
Gene Product:
Sec61betaUniProtKB:A1Z9S7
Part 2: post-translational translocation partner
Sec62-Sec63 complexProtein Complexsec62_sec63_complex

Annotons

Sec62-Sec63 complex
sec62_sec63_complex_complex
Participant: Protein Complex: Sec62-Sec63 complex
Protein Complex:
Sec62-Sec63 complexGO:0031207
Active units:
Sec63
Participant: Gene Product: Sec63
Gene Product:
Sec63UniProtKB:Q9VS57
Trp1
Participant: Gene Product: Trp1
Gene Product:
Trp1UniProtKB:Q9VL49

Processes

post-translational protein targeting to membrane, translocationGO:0031204
Part 3: substrate-specific translocation assistance
Translocon-associated proteinsProtein Complextranslocon_associated_proteins

TRAM and the delta subunit of the TRAP complex.

Annotons

TRAM Translocon-associated proteins
translocon_associated_proteins_tram
Participant: Gene Product: TRAM
Gene Product:
TRAMUniProtKB:Q9W5C2
Tapdelta Translocon-associated proteins
translocon_associated_proteins_tapdelta
Participant: Gene Product: Tapdelta
Gene Product:
TapdeltaUniProtKB:A0A0B4LF68