The signal peptidase complex in the endoplasmic reticulum membrane cleaves N-terminal signal peptides from secretory and membrane proteins as they are translocated. Its catalytic subunit, SEC11 (encoded in Drosophila by twr), is a membrane-anchored serine protease whose active site faces the ER lumen. The accessory subunits SPCS1, SPCS2 and SPCS3 (Spase12, Spase25 and Spase22-23) are required for activity and stability of the complex; SPCS3 also helps select substrates.
Decomposition. The catalytic subunit and the accessory subunits are modelled as two parts. The BP term for signal peptide processing is obsolete in GO, so no process term is attached. FlyBase groups realized by this module: SPC (FBgg0001452). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_signal_peptidase_complex.yaml. Member genes with a gene review in this repository: Spase12, Spase22-23, Spase25, twr.
All recommended fields populated.
✗ none found
No MODULE:dmel_signal_peptidase_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| spc_catalytic_twr | twr UniProtKB:O97066 Gene |
signal peptidase activity GO:0009003 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
4 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Spase12 Q9VAL0 | ✓ | ✓ | ✓ |
| Spase22-23 Q9VCA9 | ✓ | ✓ | ✓ |
| Spase25 Q9VYY2 | ✓ | ✓ | ✓ |
| twr O97066 | ✓ | ✓ | ✓ |
ER membrane protease complex whose SEC11 subunit removes signal peptides from translocated proteins.