SREBP-SCAP complex in Drosophila melanogaster

SREBP is a membrane-bound basic helix-loop-helix leucine zipper transcription factor held in the endoplasmic reticulum by its escort protein SCAP. When lipid levels fall, SCAP carries SREBP to the Golgi, where two proteolytic cleavages release the N-terminal transcription factor domain, which enters the nucleus and activates genes of lipid synthesis. In Drosophila, which cannot make sterols, SREBP processing is controlled by phosphatidylethanolamine rather than by sterols, and SREBP mainly regulates fatty acid synthesis.

MODULE:dmel_srebp_scap_complexDRAFTCONCRETEProtein Complexmodules/dmel_srebp_scap_complex.yaml
SREBP-SCAP complexGO:0032936
FB:FBgg0002067
FlyBase gene group SREBP-SCAP: Srebp-scap complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as srebp-scap complex (SREBP-SCAP); this module models that group.
GO:0032936
SREBP-SCAP complex
GO term grounding the module as SREBP-SCAP complex.

The Golgi site-1 and site-2 proteases that release SREBP and the COPII machinery are outside the module. No molecular function is assigned to SCAP. FlyBase groups realized by this module: SREBP-SCAP (FBgg0002067). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_srebp_scap_complex.yaml. Member genes with a gene review in this repository: SCAP, SREBP.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_srebp_scap_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_srebp_scap_complex_srebp_srebp SREBP
UniProtKB:Q9VW37
Gene 		DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000981 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/2 grounded genes reviewed)

2 complete review(s) · 1 with deep research · 0 missing review · 1 reviewed but lacking deep research

Gene Review Complete Deep research
SCAP A1Z6J2 ✓ ✓ ✗
SREBP Q9VW37 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
SREBP-SCAP complexProtein Complexdmel_srebp_scap_complex

ER-retained SREBP-SCAP escort complex whose transport to the Golgi releases the SREBP transcription factor to activate lipid synthesis genes.

SREBP-SCAP complexGO:0032936
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: ER-to-Golgi escort and lipid sensor
SCAPModuledmel_srebp_scap_complex_scap

Annotons

SCAP subunit
dmel_srebp_scap_complex_scap_scap
Participant: Gene Product: SCAP
Gene Product:
SCAPUniProtKB:A1Z6J2

ER-to-Golgi escort and lipid sensor

Part 2: membrane-bound transcription factor
SREBPModuledmel_srebp_scap_complex_srebp

Annotons

SREBP subunit
dmel_srebp_scap_complex_srebp_srebp
Participant: Gene Product: SREBP
Gene Product:
SREBPUniProtKB:Q9VW37

Function

DNA-binding transcription factor activity, RNA polymerase II-specificGO:0000981

membrane-bound transcription factor