STRIPAK complex in Drosophila melanogaster

The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, conserved assembly built around a PP2A phosphatase whose regulatory B subunit is a striatin. In Drosophila the striatin is Connector of kinase to AP-1 (Cka), which binds the PP2A scaffold (A) subunit Pp2A-29B and the catalytic subunit Microtubule star (Mts) together with Mob4, Strip, Slmap and Fgop2. Ccm3 links germinal-centre kinase III family kinases to the complex. STRIPAK restrains the Hippo pathway by dephosphorylating the Hippo kinase, and also acts in JNK signaling, axon transport, synapse development and centrosome positioning.

MODULE:dmel_stripak_complexDRAFTCONCRETEProtein Complexmodules/dmel_stripak_complex.yaml
FAR/SIP/STRIPAK complexGO:0090443
FB:FBgg0000915
FlyBase gene group STRIPAK: Striatin-interacting phosphatase and kinase complex
FlyBase release FB2026_03 groups 9 D. melanogaster genes as striatin-interacting phosphatase and kinase complex (STRIPAK); this module models that group.
GO:0090443
FAR/SIP/STRIPAK complex
GO term grounding the module as FAR/SIP/STRIPAK complex.

The PP2A core subunits mts and Pp2A-29B are shared with dmel_pp2a_holoenzymes. GCKIII kinases (GckIII) and the Hippo kinase (hpo) are binding partners or substrates and are not parts. The position of Fgop2 and Slmap within the complex is inferred from mammalian STRIPAK. FlyBase groups realized by this module: STRIPAK (FBgg0000915). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_stripak_complex.yaml. Member genes with a gene review in this repository: mts, Pp2A-29B.

4Nodes
3Parts
0Variant Sets
0Variants
4Annotons
1Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_stripak_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
pp2a_core_complex/mts mts
UniProtKB:P23696
Complex Unit
protein serine/threonine phosphatase activity
GO:0004722
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (2/9 grounded genes reviewed)

0 complete review(s) · 2 with deep research · 7 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Slmap A0ACM8Q165 ✗ — —
Cka M9NEC0 ✗ — —
mts P23696 ✓ 88/91 ✓
Pp2A-29B P36179 ✓ 67/69 ✓
Mob4 Q7K0E3 ✗ — —
Strip Q8IRD5 ✗ — —
Naus Q8SX68 ✗ — —
Ccm3 Q9VF70 ✗ — —
Fgop2 Q9VM65 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
STRIPAK complexProtein Complexdmel_stripak_complex

Cka-PP2A phosphatase complex with Mob4, Strip, Slmap and kinase adaptors that dephosphorylates Hippo and other targets.

FAR/SIP/STRIPAK complexGO:0090443
Context
Drosophila melanogasterNCBITaxon:7227

Connections

striatin_scaffold -> pp2a_core Positively Regulates
Cka acts as the B subunit that directs the PP2A core enzyme to STRIPAK targets.
Part 1: phosphatase catalytic core
PP2A core enzymeProtein Complexpp2a_core

Annotons

PP2A A-C core dimer
pp2a_core_complex
Participant: Protein Complex: PP2A A-C core dimer
Protein Complex:
PP2A A-C core dimer
Active units:
mts
Participant: Gene Product: mts
Gene Product:
Function:
protein serine/threonine phosphatase activityGO:0004722
Pp2A-29B
Participant: Gene Product: Pp2A-29B
Gene Product:
Part 2: PP2A B subunit and scaffold
Striatin scaffold and associated subunitsProtein Complexstriatin_scaffold

Cka (striatin) with Mob4, Strip, Slmap and Fgop2, the conserved non-catalytic STRIPAK core subunits.

Annotons

Striatin-Mob4-Strip-Slmap-Fgop2 assembly
striatin_scaffold_complex
Participant: Protein Complex: Striatin-Mob4-Strip-Slmap-Fgop2 assembly
Protein Complex:
Striatin-Mob4-Strip-Slmap-Fgop2 assembly
Active units:
Cka
Participant: Gene Product: Cka
Gene Product:
Mob4
Participant: Gene Product: Mob4
Gene Product:
Strip
Participant: Gene Product: Strip
Gene Product:
Slmap
Participant: Gene Product: Slmap
Gene Product:
Fgop2
Participant: Gene Product: Fgop2
Gene Product:
Part 3: kinase recruitment and accessory subunits
Kinase adaptor and accessory subunitsProtein Complexstripak_accessory

Ccm3 (PDCD10 homolog), which binds GCKIII kinases, and Nausicaa (Naus), a CTTNBP2NL homolog.

Annotons

Ccm3 Kinase adaptor and accessory subunits
stripak_accessory_ccm3
Participant: Gene Product: Ccm3
Gene Product:
Naus Kinase adaptor and accessory subunits
stripak_accessory_naus
Participant: Gene Product: Naus
Gene Product: