STRIPAK complex in Drosophila melanogaster
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, conserved assembly built around a PP2A phosphatase whose regulatory B subunit is a striatin. In Drosophila the striatin is Connector of kinase to AP-1 (Cka), which binds the PP2A scaffold (A) subunit Pp2A-29B and the catalytic subunit Microtubule star (Mts) together with Mob4, Strip, Slmap and Fgop2. Ccm3 links germinal-centre kinase III family kinases to the complex. STRIPAK restrains the Hippo pathway by dephosphorylating the Hippo kinase, and also acts in JNK signaling, axon transport, synapse development and centrosome positioning.
The PP2A core subunits mts and Pp2A-29B are shared with dmel_pp2a_holoenzymes. GCKIII kinases (GckIII) and the Hippo kinase (hpo) are binding partners or substrates and are not parts. The position of Fgop2 and Slmap within the complex is inferred from mammalian STRIPAK. FlyBase groups realized by this module: STRIPAK (FBgg0000915). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_stripak_complex.yaml. Member genes with a gene review in this repository: mts, Pp2A-29B.
Derived QC
Recommended-field compliance
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_stripak_complex deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| pp2a_core_complex/mts | mts UniProtKB:P23696 Complex Unit |
protein serine/threonine phosphatase activity GO:0004722 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
Gene-review completeness (2/9 grounded genes reviewed)
0 complete review(s) · 2 with deep research · 7 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Slmap A0ACM8Q165 | ✗ | — | — |
| Cka M9NEC0 | ✗ | — | — |
| mts P23696 | ✓ | 88/91 | ✓ |
| Pp2A-29B P36179 | ✓ | 67/69 | ✓ |
| Mob4 Q7K0E3 | ✗ | — | — |
| Strip Q8IRD5 | ✗ | — | — |
| Naus Q8SX68 | ✗ | — | — |
| Ccm3 Q9VF70 | ✗ | — | — |
| Fgop2 Q9VM65 | ✗ | — | — |
Details
Cka-PP2A phosphatase complex with Mob4, Strip, Slmap and kinase adaptors that dephosphorylates Hippo and other targets.
Connections
Annotons
Cka (striatin) with Mob4, Strip, Slmap and Fgop2, the conserved non-catalytic STRIPAK core subunits.
Annotons
Ccm3 (PDCD10 homolog), which binds GCKIII kinases, and Nausicaa (Naus), a CTTNBP2NL homolog.