Hydrogen sulfide produced by cysteine catabolism and gut microbes is detoxified in the mitochondrial matrix. Sulfide:quinone oxidoreductase (Sqor) oxidises sulfide to a protein-bound persulfide, passing the electrons to ubiquinone in the respiratory chain. The persulfide sulfur is then oxidised to sulfite by the persulfide dioxygenase ETHE1 (CG30022 in flies) or transferred to sulfite to form thiosulfate. Sulfite oxidase (shop) oxidises sulfite to sulfate, and the mitochondrial dicarboxylate carrier (Dic1) can export thiosulfate and sulfate in exchange for other anions.
Boundary. The sulfurtransferase (rhodanese) step that makes thiosulfate is not in the FlyBase group and is not modelled. CG30022 is the fly ortholog of ETHE1 (UniProt names it persulfide dioxygenase ETHE1); its activity and those of Sqor follow orthology and have not been assayed in flies. Dic1 transport of thiosulfate, sulfate and dicarboxylates has been shown in reconstituted proteoliposomes; Dic1 also transports malate, succinate and phosphate, so its role here is one of several. Sulfite oxidase also handles sulfite from cysteine catabolism. FlyBase groups realized by this module: SULOXID (FBgg0002230). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_sulfide_oxidation.yaml. Member genes with a gene review in this repository: CG30022, Dic1, shop, Sqor.
All recommended fields populated.
✗ none found
No MODULE:dmel_sulfide_oxidation deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
3 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| sulfide_quinone_oxidation_sqor | Sqor UniProtKB:Q9VZF6 Gene |
sulfide:quinone oxidoreductase activity GO:0070224 |
Review Disagreement
The review removes, modifies, or marks this term over-annotated and provides no retained/core support. Review the rationale; rejection of an evidence row alone is not a biological NOT. |
| persulfide_dioxygenation_cg30022 | CG30022 UniProtKB:A0ACM8PZC4 Gene |
sulfur dioxygenase activity GO:0050313 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| sulfite_oxidation_shop | shop UniProtKB:Q9VWP4 Gene |
sulfite oxidase activity GO:0008482 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| anion_export_dic1 | Dic1 UniProtKB:Q9Y166 Gene |
thiosulfate transmembrane transporter activity GO:0015117 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
4 complete review(s) · 4 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| CG30022 A0ACM8PZC4 | ✓ | ✓ | ✓ |
| Dic1 Q9Y166 | ✓ | ✓ | ✓ |
| shop Q9VWP4 | ✓ | ✓ | ✓ |
| Sqor Q9VZF6 | ✓ | ✓ | ✓ |
Mitochondrial oxidation of hydrogen sulfide through persulfide and sulfite to thiosulfate and sulfate.