The SWR1-type complex deposits the histone variant H2Av into nucleosomes in exchange for H2A. Its catalytic subunit is the SWR1-family ATPase Domino; in Drosophila the Domino-B isoform forms this complex, whereas Domino-A is part of the Tip60 complex. The complex shares with Tip60 the AAA+ ATPases Pontin and Reptin, YL-1, DMAP1, Gas41, Bap55 and the MRG15 module, and contains the actin-related protein Arp6.
Grouping of accessory subunits follows the conserved SWR1/SRCAP organisation and is a modelling convenience. The Domino isoform specificity (Domino-B here, Domino-A in Tip60) cannot be represented with gene-level participants; both modules use the dom gene product. Hcf is included because FlyBase lists it in the SWR1 group. FlyBase groups realized by this module: SWR1 (FBgg0001790). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_swr1_domino_complex.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_swr1_domino_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| swr1_domino_atpase_dom | dom UniProtKB:Q9NDJ2 Gene |
ATP-dependent chromatin remodeler activity GO:0140658 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
0 complete review(s) · 0 with deep research · 12 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Bap55 A1ZAS6 | ✗ | — | — |
| Arp6 P45890 | ✗ | — | — |
| MrgBP Q7K003 | ✗ | — | — |
| DMAP1 Q7K3D8 | ✗ | — | — |
| dom Q9NDJ2 | ✗ | — | — |
| rept Q9V3K3 | ✗ | — | — |
| Hcf Q9V4C8 | ✗ | — | — |
| Brd8 Q9VAM5 | ✗ | — | — |
| pont Q9VH07 | ✗ | — | — |
| YL-1 Q9VKM6 | ✗ | — | — |
| Gas41 Q9VM63 | ✗ | — | — |
| MRG15 Q9Y0I1 | ✗ | — | — |
Domino-containing SWR1-type complex that deposits the H2A variant H2Av.