Topoisomerase 3-beta (TOP3B) is a type IA topoisomerase that can act on both DNA and RNA. It forms a conserved complex with the Tudor-domain protein TDRD3, which stimulates its activity, recruits it to messenger ribonucleoprotein complexes and links it to the fragile X protein FMRP. In Drosophila, Top3beta and Tdrd3 associate with each other and with Fmr1, and the complex has been implicated in synapse formation and in mRNA translation.
Modelled one part per subunit. Top3beta is given DNA topoisomerase activity; RNA topoisomerase activity has been reported for TOP3B including in flies but is not asserted here. Fmr1 is a partner, not a FlyBase member, and is not a part. FlyBase groups realized by this module: TDRD3-TOP3B (FBgg0001994). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_tdrd3_top3b_complex.yaml. Member genes with a gene review in this repository: Tdrd3, Top3beta.
All recommended fields populated.
✗ none found
No MODULE:dmel_tdrd3_top3b_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| top3beta_subunit_top3beta | Top3beta UniProtKB:O96651 Gene |
DNA topoisomerase type I (single strand cut, ATP-independent) activity GO:0003917 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
2 complete review(s) · 2 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Tdrd3 Q9VUH8 | ✓ | ✓ | ✓ |
| Top3beta O96651 | ✓ | ✓ | ✓ |
Type IA topoisomerase Top3beta with its Tudor-domain partner Tdrd3, acting on RNA and DNA.