Drosophila telomeres are maintained by retrotransposons rather than telomerase, and their capping is sequence-independent. The terminin complex binds chromosome ends and prevents them from being recognised as DNA breaks and fused. It contains HOAP (encoded by caravaggio, cav) with HipHop, which together with HP1 form the HipHop-HOAP subcomplex, and the MTV subcomplex of Modigliani (Moi), Verrocchio (Ver) and Tea, which also associates with HOAP. Loss of terminin subunits causes telomere fusions.
HOAP (cav) is listed in both FlyBase subgroups and so appears in both parts. HP1 (Su(var)205) is also part of the cap but is not a member of these FlyBase groups and is not added here, because it has many roles outside telomeres. No molecular function is assigned in this version: terminin caps chromosome ends independently of DNA sequence, GO has no molecular function term for telomere capping, and the telomeric DNA binding terms that Cav, Moi and Ver carry in GOA are not yet used as annoton functions. FlyBase groups realized by this module: HHTC (FBgg0001969), MTV (FBgg0001970). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_terminin_telomere_capping.yaml. Member genes with a gene review in this repository: cav, HipHop, moi, tea, ver.
All recommended fields populated.
✗ none found
No MODULE:dmel_terminin_telomere_capping deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
No functional claims were checked. This does not establish consistency with gene or family reviews.
4 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| cav Q95RV2 | ✓ | ✓ | ✓ |
| HipHop Q7JWP6 | ✓ | 15/16 | ✓ |
| moi B7Z0L8 | ✓ | ✓ | ✓ |
| tea E1JH25 | ✓ | ✓ | ✓ |
| ver Q9VTZ2 | ✓ | ✓ | ✓ |
Fast-evolving telomere cap of HipHop-HOAP and Moi-Tea-Ver that prevents end-to-end chromosome fusions.