Tip60 histone acetyltransferase and exchange complex in Drosophila melanogaster

The Drosophila Tip60 complex combines the activities that budding yeast splits between NuA4 and SWR1. Its MYST-family acetyltransferase Tip60 acetylates nucleosomal histone H4 and the H2A variant H2Av, and the SWR1-family ATPase Domino exchanges phosphorylated H2Av for unmodified H2Av, which links the complex to DNA damage responses. The complex also contains the AAA+ ATPases Pontin and Reptin, the Tra1 homolog Nipped-A, actin, and chromatin-reader subunits including MRG15, Brd8 and Gas41. It contributes to transcriptional regulation, DNA repair and cell-cycle control.

MODULE:dmel_tip60_complexDRAFTCONCRETEProtein Complexmodules/dmel_tip60_complex.yaml
NuA4 histone acetyltransferase complexGO:0035267
FB:FBgg0000287
FlyBase gene group TIP60: Tip60 complex
FlyBase release FB2026_03 groups 16 D. melanogaster genes as tip60 complex (TIP60); this module models that group.
GO:0035267
NuA4 histone acetyltransferase complex
GO term grounding the module as NuA4 histone acetyltransferase complex.

Subunit grouping into acetyltransferase core, MRG15 module, Domino module and Tra1 follows the conserved organisation of NuA4 and SWR1 in yeast and the TIP60 complex in mammals; it is a modelling convenience, not a claim about separable Drosophila subcomplexes. The Domino-B-containing complex without Tip60 is modelled separately in dmel_swr1_domino_complex. FlyBase groups realized by this module: TIP60 (FBgg0000287). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_tip60_complex.yaml. Member genes with a gene review in this repository: Eaf6.

5Nodes
4Parts
0Variant Sets
0Variants
4Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_tip60_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
tip60_piccolo_hat_core_complex/tip60 Tip60
UniProtKB:Q960X4
Complex Unit
histone acetyltransferase activity
GO:0004402
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.
tip60_domino_module_complex/dom dom
UniProtKB:Q9NDJ2
Complex Unit
ATP-dependent chromatin remodeler activity
GO:0140658
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked.

Gene-review completeness (1/16 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 15 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
E(Pc) A0A0B4KFP2 ✗ — —
Bap55 A1ZAS6 ✗ — —
Eaf6 Q9VRN3 ✓ 9/11 ✓
Act87E P10981 ✗ — —
MrgBP Q7K003 ✗ — —
DMAP1 Q7K3D8 ✗ — —
Nipped-A Q8I8U7 ✗ — —
Tip60 Q960X4 ✗ — —
dom Q9NDJ2 ✗ — —
rept Q9V3K3 ✗ — —
Brd8 Q9VAM5 ✗ — —
pont Q9VH07 ✗ — —
YL-1 Q9VKM6 ✗ — —
Gas41 Q9VM63 ✗ — —
Ing3 Q9VWS0 ✗ — —
MRG15 Q9Y0I1 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Tip60 complexProtein Complexdmel_tip60_complex

Tip60 acetyltransferase complex that also contains the Domino ATPase for H2Av exchange.

NuA4 histone acetyltransferase complexGO:0035267
Context
Drosophila melanogasterNCBITaxon:7227
chromatinGO:0000785
Part 1: histone H4 and H2Av acetylation
Tip60 acetyltransferase coreProtein Complextip60_piccolo_hat_core

The catalytic core homologous to yeast piccolo NuA4 (Esa1, Epl1, Yng2, Eaf6).

Annotons

Tip60 acetyltransferase core
tip60_piccolo_hat_core_complex
Participant: Protein Complex: Tip60 acetyltransferase core
Protein Complex:
Tip60 acetyltransferase coreGO:0032777
Active units:
Tip60
Participant: Gene Product: Tip60
Gene Product:
Function:
histone acetyltransferase activityGO:0004402
E(Pc)
Participant: Gene Product: E(Pc)
Gene Product:
Ing3
Participant: Gene Product: Ing3
Gene Product:
Eaf6
Participant: Gene Product: Eaf6
Gene Product:
Part 2: chromatin reader subunits
MRG15 reader moduleProtein Complextip60_mrg15_module

Annotons

MRG15 reader module
tip60_mrg15_module_complex
Participant: Protein Complex: MRG15 reader module
Protein Complex:
MRG15 reader module
Active units:
MRG15
Participant: Gene Product: MRG15
Gene Product:
MrgBP
Participant: Gene Product: MrgBP
Gene Product:
Brd8
Participant: Gene Product: Brd8
Gene Product:
Part 3: H2Av exchange
Domino exchange moduleProtein Complextip60_domino_module

Domino ATPase with the subunits shared with SWR1-type complexes.

Annotons

Domino exchange module
tip60_domino_module_complex
Participant: Protein Complex: Domino exchange module
Protein Complex:
Domino exchange module
Active units:
dom
Participant: Gene Product: dom
Gene Product:
Function:
ATP-dependent chromatin remodeler activityGO:0140658
YL-1
Participant: Gene Product: YL-1
Gene Product:
DMAP1
Participant: Gene Product: DMAP1
Gene Product:
Gas41
Participant: Gene Product: Gas41
Gene Product:
Bap55
Participant: Gene Product: Bap55
Gene Product:
Act87E
Participant: Gene Product: Act87E
Gene Product:
pont
Participant: Gene Product: pont
Gene Product:
rept
Participant: Gene Product: rept
Gene Product:
Part 4: activator-interacting subunit
Nipped-A (Tra1)Protein Complextip60_tra1

Annotons

Nipped-A Nipped-A (Tra1)
tip60_tra1_nipped_a
Participant: Gene Product: Nipped-A
Gene Product: