Tip60 histone acetyltransferase and exchange complex in Drosophila melanogaster
The Drosophila Tip60 complex combines the activities that budding yeast splits between NuA4 and SWR1. Its MYST-family acetyltransferase Tip60 acetylates nucleosomal histone H4 and the H2A variant H2Av, and the SWR1-family ATPase Domino exchanges phosphorylated H2Av for unmodified H2Av, which links the complex to DNA damage responses. The complex also contains the AAA+ ATPases Pontin and Reptin, the Tra1 homolog Nipped-A, actin, and chromatin-reader subunits including MRG15, Brd8 and Gas41. It contributes to transcriptional regulation, DNA repair and cell-cycle control.
Subunit grouping into acetyltransferase core, MRG15 module, Domino module and Tra1 follows the conserved organisation of NuA4 and SWR1 in yeast and the TIP60 complex in mammals; it is a modelling convenience, not a claim about separable Drosophila subcomplexes. The Domino-B-containing complex without Tip60 is modelled separately in dmel_swr1_domino_complex. FlyBase groups realized by this module: TIP60 (FBgg0000287). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_tip60_complex.yaml. Member genes with a gene review in this repository: Eaf6.
Derived QC
Recommended-field compliance
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_tip60_complex deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 2 evidence or coverage gap(s) (2 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| tip60_piccolo_hat_core_complex/tip60 | Tip60 UniProtKB:Q960X4 Complex Unit |
histone acetyltransferase activity GO:0004402 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| tip60_domino_module_complex/dom | dom UniProtKB:Q9NDJ2 Complex Unit |
ATP-dependent chromatin remodeler activity GO:0140658 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
Gene-review completeness (1/16 grounded genes reviewed)
0 complete review(s) · 1 with deep research · 15 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| E(Pc) A0A0B4KFP2 | ✗ | — | — |
| Bap55 A1ZAS6 | ✗ | — | — |
| Eaf6 Q9VRN3 | ✓ | 9/11 | ✓ |
| Act87E P10981 | ✗ | — | — |
| MrgBP Q7K003 | ✗ | — | — |
| DMAP1 Q7K3D8 | ✗ | — | — |
| Nipped-A Q8I8U7 | ✗ | — | — |
| Tip60 Q960X4 | ✗ | — | — |
| dom Q9NDJ2 | ✗ | — | — |
| rept Q9V3K3 | ✗ | — | — |
| Brd8 Q9VAM5 | ✗ | — | — |
| pont Q9VH07 | ✗ | — | — |
| YL-1 Q9VKM6 | ✗ | — | — |
| Gas41 Q9VM63 | ✗ | — | — |
| Ing3 Q9VWS0 | ✗ | — | — |
| MRG15 Q9Y0I1 | ✗ | — | — |
Details
Tip60 acetyltransferase complex that also contains the Domino ATPase for H2Av exchange.
The catalytic core homologous to yeast piccolo NuA4 (Esa1, Epl1, Yng2, Eaf6).
Annotons
Annotons
Domino ATPase with the subunits shared with SWR1-type complexes.