TOR complexes TORC1 and TORC2 in Drosophila melanogaster

The serine/threonine kinase TOR acts in two distinct complexes. TORC1, defined by the substrate-recruiting subunit Raptor, is rapamycin-sensitive, is activated by amino acids and growth factors through the Rag and Rheb GTPases, and promotes growth by phosphorylating S6 kinase and the translation inhibitor 4E-BP (Thor) while repressing autophagy. TORC2, defined by Rictor and Sin1 together with Lst8, phosphorylates Akt at its hydrophobic motif and contributes to growth control and cytoskeletal regulation.

MODULE:dmel_tor_complexesDRAFTCONCRETEProtein Complexmodules/dmel_tor_complexes.yaml
TOR complexGO:0038201
FB:FBgg0000911
FlyBase gene group TOR: Tor complexes
FlyBase release FB2026_03 groups 5 D. melanogaster genes as tor complexes (TOR); this module models that group.
GO:0038201
TOR complex
GO term grounding the module as TOR complex.

Boundary. Membership follows FlyBase; FlyBase lists Lst8 only in TORC2, although Lst8 is also a TORC1 subunit in other organisms. Upstream regulators (Rag and Rheb GTPases, GATOR, TSC) are modelled in dmel_torc1_nutrient_sensing. FlyBase groups realized by this module: TOR (FBgg0000911). Subgroups folded into it: TORC1, TORC2. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_tor_complexes.yaml. Member genes with a gene review in this repository: Lst8, mTor, raptor, rictor, Sin1.

3Nodes
2Parts
0Variant Sets
0Variants
2Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_tor_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

2 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (2 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
torc1_complex/mtor mTor
UniProtKB:Q9VK45
Complex Unit 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).
torc2_complex/mtor mTor
UniProtKB:Q9VK45
Complex Unit 		protein serine/threonine kinase activity
GO:0004674 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (5/5 grounded genes reviewed)

2 complete review(s) · 5 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Lst8 Q9W328 ✓ 25/26 ✓
mTor Q9VK45 ✓ 76/77 ✓
raptor Q9W437 ✓ 21/23 ✓
rictor Q9VWJ6 ✓ ✓ ✓
Sin1 Q9V719 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
TOR complexesProtein Complexdmel_tor_complexes

TOR kinase complexes TORC1 (TOR-Raptor) and TORC2 (TOR-Rictor-Sin1-Lst8).

TOR complexGO:0038201
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: nutrient-regulated growth kinase complex
TORC1 complexProtein Complextorc1

Annotons

TORC1 complex
torc1_complex
Participant: Protein Complex: TORC1 complex
Protein Complex:
TORC1 complexGO:0031931
Active units:
mTor
Participant: Gene Product: mTor
Gene Product:
mTorUniProtKB:Q9VK45
Role: catalytic subunit
Function:
protein serine/threonine kinase activityGO:0004674
raptor
Participant: Gene Product: raptor
Gene Product:
raptorUniProtKB:Q9W437
Role: substrate-recruiting subunit

Processes

TORC1 signalingGO:0038202
Part 2: Akt hydrophobic-motif kinase complex
TORC2 complexProtein Complextorc2

Annotons

TORC2 complex
torc2_complex
Participant: Protein Complex: TORC2 complex
Protein Complex:
TORC2 complexGO:0031932
Active units:
Lst8
Participant: Gene Product: Lst8
Gene Product:
Lst8UniProtKB:Q9W328
Role: shared regulatory subunit
Sin1
Participant: Gene Product: Sin1
Gene Product:
Sin1UniProtKB:Q9V719
Role: defining subunit
mTor
Participant: Gene Product: mTor
Gene Product:
mTorUniProtKB:Q9VK45
Role: catalytic subunit
Function:
protein serine/threonine kinase activityGO:0004674
rictor
Participant: Gene Product: rictor
Gene Product:
rictorUniProtKB:Q9VWJ6
Role: defining subunit