GATOR2 complex
gator2_complex
Participant: Protein Complex: GATOR2 complex
Protein Complex:
TORC1 nutrient- and growth-factor-sensing machinery in Drosophila melanogaster
TORC1 is activated on the lysosome surface only when two inputs coincide. Amino acid sufficiency is relayed through the heterodimeric Rag GTPases (RagA-B with RagC-D), which are anchored to the lysosome by the pentameric Ragulator complex and recruit TORC1 when RagA-B is GTP-bound. The GATOR1 complex (Iml1, Nprl2, Nprl3) acts as a GTPase-activating protein for RagA-B and so inhibits TORC1, and the GATOR2 complex (Mio, Wdr24, Wdr59, Seh1 and Sec13) inhibits GATOR1. Growth-factor and energy signals are relayed through the TSC1-TSC2 complex (Tsc1 and Gigas), a GTPase-activating protein for the small GTPase Rheb, which directly activates TORC1. In Drosophila, GATOR1 and GATOR2 regulate TORC1 activity in the ovary and other tissues, and TSC mutations cause cell overgrowth.
regulation of TORC1 signalingGO:1903432
FB:FBgg0000050
FlyBase gene group SEA: Gator complexes
FlyBase release FB2026_03 groups 8 D. melanogaster genes as gator complexes (SEA); this module models that group.
FB:FBgg0000321
FlyBase gene group RAG: Rag gtpase complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as rag gtpase complex (RAG); this module models that group.
FB:FBgg0000905
FlyBase gene group TSC1-2C: Tsc1-tsc2 complex
FlyBase release FB2026_03 groups 2 D. melanogaster genes as tsc1-tsc2 complex (TSC1-2C); this module models that group.
FB:FBgg0001685
FlyBase gene group LAMTOR: Ragulator complex
FlyBase release FB2026_03 groups 5 D. melanogaster genes as ragulator complex (LAMTOR); this module models that group.
FB:FBgg0002204
FlyBase gene group RAGGEF: Rag guanine nucleotide exchange factors
FlyBase release FB2026_03 groups 2 D. melanogaster genes as rag guanine nucleotide exchange factors (RAGGEF); this module models that group.
GO:1903432
regulation of TORC1 signaling
GO term grounding the module as regulation of TORC1 signaling.
Boundary. TORC1 itself is modelled in dmel_tor_complexes; this module holds the upstream regulators that act on the Rag and Rheb GTPases. Rheb is not a member of these FlyBase groups and is added as the textbook substrate of the TSC complex and direct activator of TORC1. The GATOR1 GAP activity and the Ragulator structure are best characterized in mammalian and yeast orthologs. FlyBase groups realized by this module: SEA (FBgg0000050), RAG (FBgg0000321), TSC1-2C (FBgg0000905), LAMTOR (FBgg0001685), RAGGEF (FBgg0002204). Subgroups folded into it: GAT1, GAT2. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_torc1_nutrient_sensing.yaml. Member genes with a gene review in this repository: Iml1, Nprl2, Nprl3.
7Nodes
6Parts
0Variant Sets
0Variants
6Annotons
4Connections
Derived QC
Recommended-field compliance
100.0%
recommended fields populated
All recommended fields populated.
Module deep research
✗ none found
No MODULE:dmel_torc1_nutrient_sensing deep-research report alongside the module YAML.
Leaf nodes lacking representative members
✓ every leaf node grounds to a representative protein.
Template conformance
✓ every declared conforms_to bundle matches its template motif.
Function consistency and core coverage
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 1 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| gator1_complex | PROTEIN_COMPLEX Gene |
GTPase activator activity GO:0005096 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| rag_gtpases_complex | PROTEIN_COMPLEX Gene |
GTPase activity GO:0003924 |
Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews. |
| tsc_complex_complex/gig | gig UniProtKB:Q9VW83 Complex Unit |
GTPase activator activity GO:0005096 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| rheb_rheb | Rheb UniProtKB:Q9VND8 Gene |
GTPase activity GO:0003924 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
Feedback loops (advisory, prose-driven: a regulator counts as "feedback" when its own description says so)
✓ every negative regulator described as feedback has an upstream edge closing the loop.
-
gator2 ⊣ gator1 [input]
gator2 is a negative regulator with no upstream edge (not described as feedback) -
gator1 ⊣ rag_gtpases [input]
gator1 is a negative regulator with no upstream edge (not described as feedback) -
tsc_complex ⊣ rheb [input]
tsc_complex is a negative regulator with no upstream edge (not described as feedback)
Gene-review completeness (4/18 grounded genes reviewed)
2 complete review(s) · 4 with deep research · 14 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| RagC-D A1Z7B7 | ✗ | — | — |
| Iml1 Q9W0E3 | ✓ | ✓ | ✓ |
| Nprl2 Q9VXA0 | ✓ | 31/32 | ✓ |
| Nprl3 Q9VUB4 | ✓ | 36/37 | ✓ |
| Lamtor5 O96824 | ✗ | — | — |
| Nup44A Q7K2X8 | ✗ | — | — |
| Sec13 Q9V3J4 | ✗ | — | — |
| Lamtor2 Q9V8I2 | ✗ | — | — |
| Tsc1 Q9VCC9 | ✗ | — | — |
| RagA-B Q9VHJ4 | ✗ | — | — |
| Lamtor3 Q9VJD2 | ✗ | — | — |
| Wdr59 Q9VKK2 | ✗ | — | — |
| mio Q9VQ89 | ✗ | — | — |
| Lamtor1 Q9VW73 | ✗ | — | — |
| gig Q9VW83 | ✗ | — | — |
| Lamtor4 Q9VZL6 | ✗ | — | — |
| Wdr24 Q9XZ25 | ✗ | — | — |
| Rheb Q9VND8 | ✓ | ✓ | ✓ |
Details
Context
Drosophila melanogasterNCBITaxon:7227
TORC1 upstream sensing machinerySignaling Pathwaydmel_torc1_nutrient_sensing
GATOR1, GATOR2, Ragulator, Rag GTPase and TSC-Rheb modules that couple amino acid and growth-factor signals to TORC1 activity.
regulation of TORC1 signalingGO:1903432
Context
Drosophila melanogasterNCBITaxon:7227
Connections
GATOR1 stimulates GTP hydrolysis by RagA-B.
Ragulator anchors the Rag heterodimer at the lysosome.
TSC2/Gigas stimulates GTP hydrolysis by Rheb.
Part 1: inhibitor of GATOR1
GATOR2 complexSignaling Pathwaygator2
Annotons
Part 2: GTPase-activating protein for RagA-B
GATOR1 complexSignaling Pathwaygator1
Annotons
GATOR1 complex
gator1_complex
Participant: Protein Complex: GATOR1 complex
Protein Complex:
Function
GTPase activator activityGO:0005096
Part 3: lysosomal anchor for the Rag GTPases
Ragulator complexSignaling Pathwayragulator
Pentameric Lamtor1-5 complex; FlyBase separately groups Lamtor2 and Lamtor3 as Rag guanine nucleotide exchange factors (RAGGEF).
Annotons
Ragulator complex
ragulator_complex
Participant: Protein Complex: Ragulator complex
Protein Complex:
Part 4: amino acid-dependent TORC1 recruitment
Rag GTPase heterodimerSignaling Pathwayrag_gtpases
Annotons
Rag GTPase heterodimer
rag_gtpases_complex
Participant: Protein Complex: Rag GTPase heterodimer
Protein Complex:
Function
GTPase activityGO:0003924
Part 5: GTPase-activating protein for Rheb
TSC1-TSC2 complexSignaling Pathwaytsc_complex
Annotons
TSC1-TSC2 complex
tsc_complex_complex
Participant: Protein Complex: TSC1-TSC2 complex
Protein Complex:
TSC1-TSC2 complexGO:0033596
Active units:
Tsc1
Participant: Gene Product: Tsc1
Gene Product:
Tsc1UniProtKB:Q9VCC9
Role: TSC1 ortholog, stabilizing subunit
gig
Participant: Gene Product: gig
Gene Product:
Role: TSC2 ortholog, GAP subunit
Function:
GTPase activator activityGO:0005096
Part 6: direct TORC1 activator
RhebSignaling Pathwayrheb
Annotons
Rheb Rheb
rheb_rheb
Participant: Gene Product: Rheb
Gene Product:
RhebUniProtKB:Q9VND8
Function
GTPase activityGO:0003924