TRAPP complexes in Drosophila melanogaster

Transport protein particle (TRAPP) complexes are multisubunit guanine nucleotide exchange factors for Rab GTPases in the secretory and autophagic pathways. A shared core, in which Bet3, Bet5 and Trs23 form the catalytic surface for Rab1 nucleotide exchange, is extended with Trs20, Trs31, Trs33 and the Trs20-like CG9067. Addition of the large subunits Trs120 (SIDL) and Trs130 (brunelleschi, brun) forms TRAPPII, which acts at the Golgi and in Drosophila is required for male meiotic cytokinesis; addition of Trs85 (gryzun, gry) and the TRAPPC11, TRAPPC12 and TRAPPC13 homologs forms TRAPPIII, which acts in ER-to-Golgi transport and autophagy.

MODULE:dmel_trapp_complexesDRAFTCONCRETEProtein Complexmodules/dmel_trapp_complexes.yaml
TRAPP complexGO:0030008
FB:FBgg0000149
FlyBase gene group TRAPP: Trapp complexes
FlyBase release FB2026_03 groups 13 D. melanogaster genes as trapp complexes (TRAPP); this module models that group.
FB:FBgg0002202
FlyBase gene group TRAPP-CAT: Trapp guanine nucleotide exchange factor catalytic core subunits
FlyBase release FB2026_03 groups 3 D. melanogaster genes as trapp guanine nucleotide exchange factor catalytic core subunits (TRAPP-CAT); this module models that group.
GO:0030008
TRAPP complex
GO term grounding the module as TRAPP complex.

Decomposition. The shared core is split into the FlyBase catalytic core group (Bet3, Bet5, Trs23) and the other shared subunits; the complex-specific subunits are modelled as alternatives. TRAPPII-specific subunits (SIDL, brun) and TRAPPIII-specific subunits (gry, l(3)76BDm, CG11396, CG4953) follow the FlyBase TRAPPII and TRAPPIII groups. TRAPPII is reported to activate Rab11 as well as Rab1 in some systems; that specificity is not resolved for Drosophila and is not modelled. FlyBase groups realized by this module: TRAPP (FBgg0000149), TRAPP-CAT (FBgg0002202). Subgroups folded into it: TRAPPII, TRAPPIII. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_trapp_complexes.yaml. None of the member genes has a gene review in this repository yet.

6Nodes
3Parts
1Variant Sets
2Variants
4Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_trapp_complexes deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

0 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
trapp_catalytic_core_complex PROTEIN_COMPLEX
Gene 		guanyl-nucleotide exchange factor activity
GO:0005085 		Participant Unchecked
No direct UniProt participant to compare. Abstract selectors and complex-wide activities cannot be inferred from donor or subunit gene reviews.

Gene-review completeness (0/13 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 13 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
CG9067 A1Z8I0 ✗ — —
Trs31 A1Z9U6 ✗ — —
gry Q8IRE3 ✗ — —
CG4953 Q95TN1 ✗ — —
Bet5 Q9VA95 ✗ — —
Trs33 Q9VF82 ✗ — —
SIDL Q9VFB7 ✗ — —
brun Q9VIL0 ✗ — —
Trs23 Q9VLI9 ✗ — —
CG11396 Q9VPB6 ✗ — —
Bet3 Q9VSY8 ✗ — —
Trs20 Q9VUZ1 ✗ — —
l(3)76BDm Q9VW22 ✗ — —

Details

Context
Drosophila melanogasterNCBITaxon:7227
TRAPP complexesProtein Complexdmel_trapp_complexes

Rab guanine nucleotide exchange complexes that share a Bet3-Bet5-Trs23 catalytic core and differ in their TRAPPII- or TRAPPIII-specific large subunits.

TRAPP complexGO:0030008
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: Rab GEF catalytic core
TRAPP catalytic coreProtein Complextrapp_catalytic_core

Bet3, Bet5 and Trs23, which form the Rab-binding catalytic surface.

Annotons

TRAPP catalytic core
trapp_catalytic_core_complex
Participant: Protein Complex: TRAPP catalytic core
Protein Complex:
TRAPP catalytic core
Active units:
Bet3
Participant: Gene Product: Bet3
Gene Product:
Bet3UniProtKB:Q9VSY8
Bet5
Participant: Gene Product: Bet5
Gene Product:
Bet5UniProtKB:Q9VA95
Trs23
Participant: Gene Product: Trs23
Gene Product:
Trs23UniProtKB:Q9VLI9

Function

guanyl-nucleotide exchange factor activityGO:0005085
Part 2: shared core subunits
Shared TRAPP core subunitsProtein Complextrapp_shared_accessory

Core subunits common to TRAPPII and TRAPPIII besides the catalytic Bet3-Bet5-Trs23 unit.

Annotons

Shared TRAPP core subunits
trapp_shared_accessory_complex
Participant: Protein Complex: Shared TRAPP core subunits
Protein Complex:
Shared TRAPP core subunits
Active units:
Trs20
Participant: Gene Product: Trs20
Gene Product:
Trs20UniProtKB:Q9VUZ1
CG9067
Participant: Gene Product: CG9067
Gene Product:
CG9067UniProtKB:A1Z8I0
Trs31
Participant: Gene Product: Trs31
Gene Product:
Trs31UniProtKB:A1Z9U6
Trs33
Participant: Gene Product: Trs33
Gene Product:
Trs33UniProtKB:Q9VF82
Part 3: TRAPPII or TRAPPIII identity
Complex-specific TRAPP subunitsProtein Complextrapp_specific_subunits
Variant set: TRAPPII or TRAPPIII specific subunits (One Or More)
TRAPPII-specific subunitsProtein Complextrappii_specific

Trs120 (SIDL) and Trs130 (brun).

Annotons

TRAPPII-specific subunits
trappii_specific_complex
Participant: Protein Complex: TRAPPII-specific subunits
Protein Complex:
TRAPPII-specific subunits
Active units:
SIDL
Participant: Gene Product: SIDL
Gene Product:
SIDLUniProtKB:Q9VFB7
brun
Participant: Gene Product: brun
Gene Product:
brunUniProtKB:Q9VIL0
TRAPPIII-specific subunitsProtein Complextrappiii_specific

Trs85 (gry) and the TRAPPC11, TRAPPC12 and TRAPPC13 homologs.

Annotons

TRAPPIII-specific subunits
trappiii_specific_complex
Participant: Protein Complex: TRAPPIII-specific subunits
Protein Complex:
TRAPPIII-specific subunits
Active units:
gry
Participant: Gene Product: gry
Gene Product:
gryUniProtKB:Q8IRE3
l(3)76BDm
Participant: Gene Product: l(3)76BDm
Gene Product:
l(3)76BDmUniProtKB:Q9VW22
CG11396
Participant: Gene Product: CG11396
Gene Product:
CG11396UniProtKB:Q9VPB6
CG4953
Participant: Gene Product: CG4953
Gene Product:
CG4953UniProtKB:Q95TN1