Trehalose, a glucose disaccharide, is the main circulating sugar in insect hemolymph. In the fat body, trehalose-6-phosphate synthase 1 (Tps1), a bifunctional enzyme with synthase and phosphatase domains, makes trehalose from UDP-glucose and glucose-6-phosphate. Trehalose leaves the fat body and enters target cells through the facilitative transporter Tret1, and in target tissues trehalase (Treh) hydrolyses it into two glucose molecules for glycolysis and other uses. Trehalose levels buffer hemolymph sugar and protect against stress.
Tps1 carries both the trehalose-6-phosphate synthase and the trehalose-6-phosphate phosphatase activities (flies have no separate phosphatase gene in the group); the annoton gives the synthase activity, which defines the committed step. Tret1 is in both FlyBase groups (biosynthesis and catabolism) and appears once, between the two enzymes. Treh encodes both secreted and intracellular trehalase isoforms. Glycogen and glucose metabolism, which supply and consume the substrates, are outside the module. FlyBase groups realized by this module: TREHB (FBgg0002044), TREHC (FBgg0002052). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_trehalose_metabolism.yaml. Member genes with a gene review in this repository: Tps1, Treh, Tret1.
All recommended fields populated.
✗ none found
No MODULE:dmel_trehalose_metabolism deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
3 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (3 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| trehalose_synthesis_tps1 | Tps1 UniProtKB:Q9Y119 Gene |
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity GO:0003825 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| trehalose_transport_tret1 | Tret1 UniProtKB:A1Z8N1 Gene |
trehalose transmembrane transporter activity GO:0015574 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| trehalose_hydrolysis_treh | Treh UniProtKB:Q9W2M2 Gene |
alpha,alpha-trehalase activity GO:0004555 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
3 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| Tps1 Q9Y119 | ✓ | ✓ | ✓ |
| Treh Q9W2M2 | ✓ | ✓ | ✓ |
| Tret1 A1Z8N1 | ✓ | ✓ | ✓ |
Fat-body synthesis of trehalose by Tps1, its transport by Tret1 and its hydrolysis to glucose by trehalase.