Troponin is the calcium sensor of the thin filament in striated muscle. It is a complex of three subunits bound to tropomyosin: troponin C binds calcium, troponin I inhibits actomyosin interaction at rest, and troponin T anchors the complex to tropomyosin. When calcium binds troponin C, the inhibition by troponin I is relieved and tropomyosin moves to expose myosin-binding sites on actin, allowing contraction. Drosophila has single genes for troponin I (wings up A, wupA) and troponin T (upheld, up), each producing many muscle-specific isoforms by alternative splicing, and five troponin C genes expressed in different muscles; in the indirect flight muscle TpnC4 and TpnC41C are used, with TpnC4 linked to stretch activation.
Tropomyosins (Tm1, Tm2) and actin are thin filament context and not parts. TpnC paralogs are modelled as an EXACTLY_ONE choice per complex; the muscle-specific expression pattern of TpnC25D and TpnC47D is not described here. FlyBase groups realized by this module: TPN-C (FBgg0001546). Subgroups folded into it: TPNC, TPNI, TPNT. Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_troponin_complex.yaml. None of the member genes has a gene review in this repository yet.
All recommended fields populated.
✗ none found
No MODULE:dmel_troponin_complex deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 gene-function check(s) reflected in core functions · 0 conflict(s) · 5 evidence or coverage gap(s) (5 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| tpnc41c_tpnc41c | TpnC41C UniProtKB:P47947 Gene |
calcium ion binding GO:0005509 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| tpnc4_tpnc4 | TpnC4 UniProtKB:A1Z6F9 Gene |
calcium ion binding GO:0005509 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| tpnc73f_tpnc73f | TpnC73F UniProtKB:P47949 Gene |
calcium ion binding GO:0005509 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| tpnc47d_tpnc47d | TpnC47D UniProtKB:P47948 Gene |
calcium ion binding GO:0005509 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| tpnc25d_tpnc25d | TpnC25D UniProtKB:Q9VMT2 Gene |
calcium ion binding GO:0005509 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
✓ every negative regulator described as feedback has an upstream edge closing the loop.
1 complete review(s) · 1 with deep research · 6 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| TpnC4 A1Z6F9 | ✗ | — | — |
| up P19351 | ✗ | — | — |
| TpnC41C P47947 | ✗ | — | — |
| TpnC47D P47948 | ✗ | — | — |
| TpnC73F P47949 | ✗ | — | — |
| TpnC25D Q9VMT2 | ✗ | — | — |
| wupA P36188 | ✓ | ✓ | ✓ |
Calcium-sensing troponin C, I and T complex of the striated muscle thin filament.
Each troponin complex contains one troponin C; the paralog used depends on the muscle type.