Usp12/46 deubiquitinase complex in Drosophila melanogaster

Usp12-46 is the single Drosophila ortholog of the human ubiquitin-specific proteases USP12 and USP46. As in humans, it forms a complex with two WD40 proteins, Uaf1 (WDR48) and Wdr20, which bind the catalytic domain and stimulate its deubiquitinase activity. In Drosophila, Usp12-46 with Uaf1 and Wdr20 has been reported to deubiquitylate and stabilize signalling components, including the Notch receptor and Arrow in Wingless signalling.

MODULE:dmel_usp46_deubiquitinase_complexDRAFTCONCRETEProtein Complexmodules/dmel_usp46_deubiquitinase_complex.yaml
peptidase complexGO:1905368
FB:FBgg0001865
FlyBase gene group USP46-C: Usp46 deubiquitinase complex
FlyBase release FB2026_03 groups 3 D. melanogaster genes as usp46 deubiquitinase complex (USP46-C); this module models that group.
GO:1905368
peptidase complex
GO term grounding the module as peptidase complex.

GO has no specific term for the USP12/46-UAF1-WDR20 complex; the module is grounded to the generic peptidase complex term. FlyBase groups realized by this module: USP46-C (FBgg0001865). Participants were generated from the FlyBase gene-group membership and mapped to UniProtKB by projects/FLYBASE_GENE_GROUPS/generate_modules.py from module_specs/dmel_usp46_deubiquitinase_complex.yaml. Member genes with a gene review in this repository: Uaf1, Usp12-46, Wdr20.

4Nodes
3Parts
0Variant Sets
0Variants
3Annotons
0Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✗ none found

No MODULE:dmel_usp46_deubiquitinase_complex deep-research report alongside the module YAML.

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Function consistency and core coverage

1 gene-function check(s) reflected in core functions · 0 conflict(s) · 0 evidence or coverage gap(s) (1 comparison(s))

Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.

AnnotonParticipantFunctionAssessment
dmel_usp46_deubiquitinase_complex_usp12_46_usp12_46 Usp12-46
UniProtKB:Q9VCT9
Gene 		deubiquitinase activity
GO:0101005 		Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass).

Gene-review completeness (3/3 grounded genes reviewed)

3 complete review(s) · 3 with deep research · 0 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
Uaf1 Q1LZ08 ✓ ✓ ✓
Usp12-46 Q9VCT9 ✓ ✓ ✓
Wdr20 Q9VBC4 ✓ ✓ ✓

Details

Context
Drosophila melanogasterNCBITaxon:7227
Usp12/46 deubiquitinase complexProtein Complexdmel_usp46_deubiquitinase_complex

Usp12-46 ubiquitin-specific protease activated by the WD40 cofactors Uaf1 and Wdr20.

peptidase complexGO:1905368
Context
Drosophila melanogasterNCBITaxon:7227
Part 1: WD40 activator (WDR48)
Uaf1Moduledmel_usp46_deubiquitinase_complex_uaf1

Annotons

Uaf1 subunit
dmel_usp46_deubiquitinase_complex_uaf1_uaf1
Participant: Gene Product: Uaf1
Gene Product:
Uaf1UniProtKB:Q1LZ08

WD40 activator (WDR48)

Part 2: catalytic ubiquitin-specific protease
Usp12-46Moduledmel_usp46_deubiquitinase_complex_usp12_46

Annotons

Usp12-46 subunit
dmel_usp46_deubiquitinase_complex_usp12_46_usp12_46
Participant: Gene Product: Usp12-46
Gene Product:
Usp12-46UniProtKB:Q9VCT9

Function

deubiquitinase activityGO:0101005

catalytic ubiquitin-specific protease

Part 3: WD40 activator
Wdr20Moduledmel_usp46_deubiquitinase_complex_wdr20

Annotons

Wdr20 subunit
dmel_usp46_deubiquitinase_complex_wdr20_wdr20
Participant: Gene Product: Wdr20
Gene Product:
Wdr20UniProtKB:Q9VBC4

WD40 activator