Function
Processes
Locations
Orients the ZGA sub-program; expanded in the dedicated MZT module.
A top-level developmental module that organises the conserved early events of animal (metazoan) embryogenesis into an ordered set of sub-programs, from the fertilised egg to a patterned, three-germ-layer embryo with a segregated germline. The trunk is a temporal sequence of four sub-programs, each detailed in its own dedicated module document: (1) the maternal-to-zygotic transition, which hands control from maternal factors to the embryo's own genome; (2) body axis specification, which converts graded morphogens into the AP, DV, and LR body axes; (3) germ layer specification during gastrulation, which partitions the embryo into endoderm, mesoderm, and ectoderm; and (4) primordial germ cell specification, which sets aside the gamete lineage. All four are wired by a small, deeply conserved "developmental toolkit" of signalling pathways - Wnt, TGF-beta/Nodal/BMP, Hedgehog, Notch, and RTK/FGF - captured here as a cross-cutting variant set that points to the existing signalling module documents. Grounded in GO:0009790 (embryo development).
This umbrella intentionally keeps each sub-program as a thin node that names its concept, exemplar regulators, and the dedicated module file that expands it, rather than duplicating the full decomposition. The sub-programs overlap in time and share machinery (e.g. the same Nodal/Wnt/BMP gradients pattern the axes AND specify germ layers), which is why the toolkit is factored out as a cross-cutting variant set. Exemplar accessions are curated human UniProt ids used only to orient conserved, pan-metazoan roles.
All recommended fields populated.
✗ none found
No MODULE:early_metazoan_development deep-research report alongside the module YAML.
6 leaf node(s) with no concrete protein grounding:
✓ every declared conforms_to bundle matches its template motif.
✓ every PRECEDES step chains, or its break is acknowledged via chaining_status.
0 complete review(s) · 0 with deep research · 4 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| TBXT (Brachyury) O15178 | ✗ | — | — |
| POU5F1 (Oct4) Q01860 | ✗ | — | — |
| SOX17 Q9H6I2 | ✗ | — | — |
| DDX4 (Vasa) Q9NQI0 | ✗ | — | — |
Maternal mRNA/protein clearance coupled to zygotic genome activation. Detailed in modules/maternal_to_zygotic_transition.yaml.
Orients the ZGA sub-program; expanded in the dedicated MZT module.
Conversion of graded morphogens into AP, DV, and LR body axes. Detailed in modules/body_axis_specification.yaml.
Orients the axis sub-program; expanded in the dedicated body-axis module.
Specification of endoderm, mesoderm, and ectoderm during gastrulation. Detailed in modules/germ_layer_specification.yaml.
Orients the germ-layer sub-program; expanded in the dedicated module.
Segregation of the gamete-forming lineage by preformation or induction. Detailed in modules/primordial_germ_cell_specification.yaml.
Orients the germline sub-program; expanded in the dedicated PGC module.
The small set of pathways deployed repeatedly across all four sub-programs. Each variant names a conserved pathway and its dedicated signalling module document; several also have gene reviews in-repo.
Posteriorising and endomesoderm-inducing; detailed in modules/wnt_signaling.yaml.
Mesendoderm induction and left/right asymmetry; detailed in modules/nodal_signaling.yaml.
Dorsal/ventral patterning and PGC induction; detailed in modules/bmp_signaling.yaml.
Juxtacrine cell-fate/boundary decisions; detailed in modules/notch_signaling.yaml.
Ventral/midline and tissue patterning; detailed in modules/hedgehog_signaling.yaml.
Mesoderm induction and posteriorisation; detailed in modules/fgfr_signaling.yaml.