EGFR signaling pathway module

EGF-family ligand binding activates EGFR/ERBB1 receptor tyrosine kinase dimers, creating phosphotyrosine docking sites that recruit GRB2/SOS, PI3K, PLCG, and STAT branches for proliferation and differentiation outputs.

MODULE:egfr_signalingDRAFTSignaling Pathwaymodules/egfr_signaling.yaml
epidermal growth factor receptor signaling pathwayGO:0007173
file:modules/egfr_signaling-deep-research-falcon.md
EGFR signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0007173
epidermal growth factor receptor signaling pathway
The module is grounded in the GO biological process term for epidermal growth factor receptor signaling pathway.
PANTHER:PTN000698827
PAINT node PTN000698827 for EGFR
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0009925, P:GO:0007173, P:GO:0043066, P:GO:0043410, P:GO:0050679; PAINT date 20250904.
PANTHER:PTN001230349
PAINT node PTN001230349 for EGFR
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, C:GO:0043235, F:GO:0004714, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN005273574
PAINT node PTN005273574 for GRB2
Local PAINT IBD node in PTHR46037 with propagated terms C:GO:0005737, C:GO:0005886, C:GO:0008180, F:GO:0001784, F:GO:0005154, P:GO:0007165; PAINT date 20260530.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • egfr_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/6 grounded genes reviewed)

1 complete review(s) · 1 with deep research · 5 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
EGFR P00533 ✓ ✓ ✓
EGF P01133 ✗ — —
ERBB2 P04626 ✗ — —
PIK3R1 P27986 ✗ — —
GRB2 P62993 ✗ — —
SOS1 Q07889 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
EGFR signaling pathwaySignaling Pathwayegfr_signaling
epidermal growth factor receptor signaling pathwayGO:0007173
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes grb2/sos adaptor recruitment.
GRB2/SOS adaptor recruitment leads to mapk/pi3k transcriptional output.
Part 1: egf ligand binds egfr
EGF ligand binds EGFRRegulatory Stepegfr_ligation

EGF-family ligands engage EGFR extracellular domains and stabilize active receptor dimers.

Annotons

EGF ligand
egf_egf_ligand
Participant: Gene Product: EGF
Gene Product:
EGFUniProtKB:P01133

Function

signaling receptor bindingGO:0005102

Curated exemplar for the egf ligand role in epidermal growth factor receptor signaling pathway.

EGFR receptor
egfr_egfr_receptor
Participant: Family: EGFR receptor family/ortholog group
Family:
EGFR receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: EGFRUniProtKB:P00533

Function

transmembrane receptor protein tyrosine kinase activityGO:0004714

Curated exemplar for the egfr receptor role in epidermal growth factor receptor signaling pathway.

Part 2: grb2/sos adaptor recruitment
GRB2/SOS adaptor recruitmentReactionegfr_adaptor_recruitment

EGFR phosphotyrosines recruit GRB2 and SOS to activate Ras.

Annotons

GRB2 adaptor
grb2_grb2_adaptor
Participant: Family: GRB2 adaptor family/ortholog group
Family:
GRB2 adaptor family/ortholog groupPANTHER:PTHR46037
Representative Members: GRB2UniProtKB:P62993

Curated exemplar for the grb2 adaptor role in epidermal growth factor receptor signaling pathway.

SOS1 Ras GEF
sos1_sos1_ras_gef
Participant: Gene Product: SOS1
Gene Product:
SOS1UniProtKB:Q07889

Function

guanyl-nucleotide exchange factor activityGO:0005085

Curated exemplar for the sos1 ras gef role in epidermal growth factor receptor signaling pathway.

Part 3: mapk/pi3k transcriptional output
MAPK/PI3K transcriptional outputRegulatory Stepegfr_effector_output

Ras-MAPK and PI3K branches relay EGFR activation to transcriptional, survival, and cell-cycle programs.

Annotons

ERBB2 paralogous RTK context
erbb2_erbb2_paralogous_rtk_context
Participant: Family: ERBB2 paralogous RTK context family/ortholog group
Family:
ERBB2 paralogous RTK context family/ortholog groupPANTHER:PTHR24416
Representative Members: ERBB2UniProtKB:P04626

Function

transmembrane receptor protein tyrosine kinase activityGO:0004714

Curated exemplar for the erbb2 paralogous rtk context role in epidermal growth factor receptor signaling pathway.

PI3K p85 adaptor
pik3r1_pi3k_p85_adaptor
Participant: Family: PI3K p85 adaptor family/ortholog group
Family:
PI3K p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pi3k p85 adaptor role in epidermal growth factor receptor signaling pathway.