Ephrin receptor signaling pathway module

Membrane-tethered ephrin ligands activate Eph receptor tyrosine kinases across cell-cell contacts, producing bidirectional signals that pattern adhesion, repulsion, migration, and vascular organization.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. The ephrin ligand step is grounded in PANTHER family PTHR11304 (EPHRIN) at the Eumetazoa root node PTN000885159, which propagates C:GO:0005886 (plasma membrane), P:GO:0048013 (ephrin receptor signaling pathway), P:GO:0007411 (axon guidance), and F:GO:0046875 (ephrin receptor binding). Following GO signaling-ligand conventions, the ligand step uses GO:0048018 (receptor ligand activity) rather than the receptor-specific binding term GO:0046875. PTN000885159 is kept on the ligand step even though its IBD MF is GO:0046875 rather than GO:0048018; the mismatch is documented in interpro/panther/PTHR11304/PTHR11304-review.yaml and explains why non-mammalian ephrins (such as Drosophila Ephrin and zebrafish ephrins) inherit GO:0048013 by IBA without a ligand-activity MF. (The module validator does not currently flag this term mismatch.) Boundary: the module models forward signaling only, from the ephrin ligand into the Eph-receptor-expressing cell. Ephrin reverse signaling (signaling into the ephrin-expressing cell, through ephrin-B cytoplasmic tail phosphorylation and PDZ partners, or ephrin-A co-receptors) is not modelled, although the ephrin-Eph contact is bidirectional. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.