Membrane-tethered ephrin ligands activate Eph receptor tyrosine kinases across cell-cell contacts, producing bidirectional signals that pattern adhesion, repulsion, migration, and vascular organization.
Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.
All recommended fields populated.
✓ present
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 complete review(s) · 0 with deep research · 5 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| EPHA2 P29317 | ✗ | — | — |
| EFNB2 P52799 | ✗ | — | — |
| EPHB4 P54760 | ✗ | — | — |
| RHOA P61586 | ✗ | — | — |
| GRB2 P62993 | ✗ | — | — |
Ephrin ligands engage Eph receptors at cell-cell interfaces.
Curated exemplar for the efnb2 ligand role in ephrin receptor signaling pathway.
Curated exemplar for the epha2 receptor role in ephrin receptor signaling pathway.
Curated exemplar for the ephb4 receptor role in ephrin receptor signaling pathway.
Eph receptor clustering activates receptor tyrosine kinase signaling.
Curated exemplar for the epha receptor kinase role in ephrin receptor signaling pathway.
Curated exemplar for the ephb receptor kinase role in ephrin receptor signaling pathway.
Ephrin receptor signaling controls cytoskeletal and adhesive responses.
Curated exemplar for the rhoa cytoskeletal switch role in ephrin receptor signaling pathway.
Curated exemplar for the sh2 adaptor context role in ephrin receptor signaling pathway.