Estrogen receptors act as ligand-regulated nuclear receptors and signaling scaffolds, recruiting co-regulators to control chromatin, transcription, and cell-type-specific hormone responses.
Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. No local PAINT IBD seed rows were found for the verified exemplar accessions in this module, so no ancestral_nodes are asserted. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.
All recommended fields populated.
✓ present
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 complete review(s) · 0 with deep research · 5 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| NCOR1 O75376 | ✗ | — | — |
| ESR1 P03372 | ✗ | — | — |
| NCOA2 Q15596 | ✗ | — | — |
| NCOA1 Q15788 | ✗ | — | — |
| ESR2 Q92731 | ✗ | — | — |
ESR1 and ESR2 are ligand-responsive estrogen receptor transcription factors.
Curated exemplar for the estrogen receptor alpha role in estrogen receptor signaling pathway.
Curated exemplar for the estrogen receptor beta role in estrogen receptor signaling pathway.
Estrogen receptors recruit nuclear receptor co-activators and co-repressors.
Curated exemplar for the nuclear receptor coactivator 1 role in estrogen receptor signaling pathway.
Curated exemplar for the nuclear receptor coactivator 2 role in estrogen receptor signaling pathway.
Curated exemplar for the nuclear receptor corepressor role in estrogen receptor signaling pathway.
Ligand-bound estrogen receptors regulate hormone-responsive transcriptional programs.
Curated exemplar for the esr1 transcriptional receptor role in estrogen receptor signaling pathway.
Curated exemplar for the coactivator context role in estrogen receptor signaling pathway.