Fc-epsilon receptor signaling pathway module

High-affinity IgE receptor signaling couples FCER1 antigen crosslinking to ITAM phosphorylation, SYK activation, BTK/PLC-gamma signaling, calcium mobilization, and mast-cell effector responses.

MODULE:fc_epsilon_receptor_signalingDRAFTSignaling Pathwaymodules/fc_epsilon_receptor_signaling.yaml

Fc-epsilon receptor signaling pathwayGO:0038095

file:modules/fc_epsilon_receptor_signaling-deep-research-falcon.md

Fc-epsilon receptor signaling pathway Falcon module review

Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.

GO:0038095

Fc-epsilon receptor signaling pathway

The module is grounded in the GO biological process term for Fc-epsilon receptor signaling pathway.

PANTHER:PTN000005673

PAINT node PTN000005673 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005737, C:GO:0016020, F:GO:0052742, P:GO:0046854; PAINT date 20260528.

PANTHER:PTN000005674

PAINT node PTN000005674 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005886, F:GO:0016303, F:GO:0035005, P:GO:0043491; PAINT date 20240205.

PANTHER:PTN000700360

PAINT node PTN000700360 for BTK

Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20221008.

PANTHER:PTN000799655

PAINT node PTN000799655 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005942; PAINT date 20240516.

PANTHER:PTN000799659

PAINT node PTN000799659 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005943, C:GO:0005944, F:GO:0046934; PAINT date 20240918.

PANTHER:PTN001231474

PAINT node PTN001231474 for BTK

Local PAINT IBD node in PTHR24418 with propagated terms F:GO:0004715; PAINT date 20221008.

PANTHER:PTN002521457

PAINT node PTN002521457 for SYK

Local PAINT IBD node in PTHR24418 with propagated terms C:GO:0005886, F:GO:0004713; PAINT date 20260529.

PANTHER:PTN002815343

PAINT node PTN002815343 for SYK

Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20210531.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes

3Parts

0Variant Sets

0Variants

7Annotons

2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

fc_epsilon_receptor_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/7 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 1 reviewed but lacking deep research

Gene	Review	Complete	Deep research
FCER1A P12319	✗	—	—
FCER1G P30273	✗	—	—
SYK P43405	✗	—	—
PIK3CG P48736	✗	—	—
PLCG2 P16885	✓	166/167	✗
MS4A2 Q01362	✗	—	—
BTK Q06187	✗	—	—

Tree

Fc-epsilon receptor signaling pathwaySignaling Pathwayfc_epsilon_receptor_signaling

Parts
1. 1. fceri receptor crosslinking
2. Fc-epsilon receptor crosslinkingRegulatory Stepfc_epsilon_receptor_crosslinking
  
  Annotons
  - FCER1 alpha ligand-binding subunit Gene Product: FCER1A
  - FCER1 beta subunit Gene Product: MS4A2
  - FCER1 gamma ITAM subunit Gene Product: FCER1G
3. 2. fceri syk activation
4. SYK activation downstream of FCER1Regulatory Stepsyk_activation_downstream_of_fcer1
  
  Annotons
  - SYK tyrosine kinase Family: SYK tyrosine kinase family/ortholog group
  - BTK tyrosine kinase Family: BTK tyrosine kinase family/ortholog group
5. 3. fceri degranulation signals
6. Calcium and degranulation outputRegulatory Stepcalcium_and_degranulation_output
  
  Annotons
  - PLCG2 effector Gene Product: PLCG2
  - PI3K catalytic branch Family: PI3K catalytic branch family/ortholog group

Details

Context

jawed vertebratesNCBITaxon:7776

plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Fc-epsilon receptor signaling pathwaySignaling Pathwayfc_epsilon_receptor_signaling

Fc-epsilon receptor signaling pathwayGO:0038095

Context

jawed vertebratesNCBITaxon:7776

plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

fc_epsilon_receptor_crosslinking -> syk_activation_downstream_of_fcer1 Causes

The initiating event promotes fceri syk activation.

syk_activation_downstream_of_fcer1 -> calcium_and_degranulation_output Causes

SYK activation downstream of FCER1 leads to fceri degranulation signals.

Part 1: fceri receptor crosslinking

Fc-epsilon receptor crosslinkingRegulatory Stepfc_epsilon_receptor_crosslinking

FCER1A, MS4A2, and FCER1G form the high-affinity IgE receptor signaling complex.

Annotons

FCER1 alpha ligand-binding subunit

fcer1a_fcer1_alpha_ligand_binding_subunit

Participant: Gene Product: FCER1A

Gene Product:

FCER1AUniProtKB:P12319

Curated exemplar for the fcer1 alpha ligand-binding subunit role in Fc-epsilon receptor signaling pathway.

FCER1 beta subunit

ms4a2_fcer1_beta_subunit

Participant: Gene Product: MS4A2

Gene Product:

MS4A2UniProtKB:Q01362

Curated exemplar for the fcer1 beta subunit role in Fc-epsilon receptor signaling pathway.

FCER1 gamma ITAM subunit

fcer1g_fcer1_gamma_itam_subunit

Participant: Gene Product: FCER1G

Gene Product:

FCER1GUniProtKB:P30273

Curated exemplar for the fcer1 gamma itam subunit role in Fc-epsilon receptor signaling pathway.

Part 2: fceri syk activation

SYK activation downstream of FCER1Regulatory Stepsyk_activation_downstream_of_fcer1

ITAM phosphorylation recruits and activates SYK family kinase signaling.

Annotons

SYK tyrosine kinase

syk_syk_tyrosine_kinase

Participant: Family: SYK tyrosine kinase family/ortholog group

Family:

SYK tyrosine kinase family/ortholog groupPANTHER:PTHR24418

Representative Members: SYKUniProtKB:P43405

Curated exemplar for the syk tyrosine kinase role in Fc-epsilon receptor signaling pathway.

BTK tyrosine kinase

btk_btk_tyrosine_kinase

Participant: Family: BTK tyrosine kinase family/ortholog group

Family:

BTK tyrosine kinase family/ortholog groupPANTHER:PTHR24418

Representative Members: BTKUniProtKB:Q06187

Curated exemplar for the btk tyrosine kinase role in Fc-epsilon receptor signaling pathway.

Part 3: fceri degranulation signals

Calcium and degranulation outputRegulatory Stepcalcium_and_degranulation_output

PLCG2 and PI3K branches support calcium mobilization and secretory effector output.

Annotons

PLCG2 effector

plcg2_plcg2_effector

Participant: Gene Product: PLCG2

Gene Product:

PLCG2UniProtKB:P16885

Curated exemplar for the plcg2 effector role in Fc-epsilon receptor signaling pathway.

PI3K catalytic branch

pik3cg_pi3k_catalytic_branch

Participant: Family: PI3K catalytic branch family/ortholog group

Family:

PI3K catalytic branch family/ortholog groupPANTHER:PTHR10048

Representative Members: PIK3CGUniProtKB:P48736

Curated exemplar for the pi3k catalytic branch role in Fc-epsilon receptor signaling pathway.