Fc-gamma receptor signaling pathway module

Fc-gamma receptor signaling couples immune-complex binding to ITAM-containing receptor chains, SYK/BTK activation, PLC-gamma and PI3K branches, phagocytosis, and inflammatory effector functions.

MODULE:fc_gamma_receptor_signalingDRAFTSignaling Pathwaymodules/fc_gamma_receptor_signaling.yaml

Fc-gamma receptor signaling pathwayGO:0038094

file:modules/fc_gamma_receptor_signaling-deep-research-falcon.md

Fc-gamma receptor signaling pathway Falcon module review

Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.

GO:0038094

Fc-gamma receptor signaling pathway

The module is grounded in the GO biological process term for Fc-gamma receptor signaling pathway.

PANTHER:PTN000005673

PAINT node PTN000005673 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005737, C:GO:0016020, F:GO:0052742, P:GO:0046854; PAINT date 20260528.

PANTHER:PTN000005674

PAINT node PTN000005674 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005886, F:GO:0016303, F:GO:0035005, P:GO:0043491; PAINT date 20240205.

PANTHER:PTN000700360

PAINT node PTN000700360 for BTK

Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20221008.

PANTHER:PTN000799655

PAINT node PTN000799655 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005942; PAINT date 20240516.

PANTHER:PTN000799659

PAINT node PTN000799659 for PIK3CG

Local PAINT IBD node in PTHR10048 with propagated terms C:GO:0005943, C:GO:0005944, F:GO:0046934; PAINT date 20240918.

PANTHER:PTN001231474

PAINT node PTN001231474 for BTK

Local PAINT IBD node in PTHR24418 with propagated terms F:GO:0004715; PAINT date 20221008.

PANTHER:PTN002521457

PAINT node PTN002521457 for SYK

Local PAINT IBD node in PTHR24418 with propagated terms C:GO:0005886, F:GO:0004713; PAINT date 20260529.

PANTHER:PTN002815343

PAINT node PTN002815343 for SYK

Local PAINT IBD node in PTHR24418 with propagated terms P:GO:0050853; PAINT date 20210531.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes

3Parts

0Variant Sets

0Variants

7Annotons

2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

fc_gamma_receptor_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/7 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 1 reviewed but lacking deep research

Gene	Review	Complete	Deep research
FCGR3A P08637	✗	—	—
FCGR2A P12318	✗	—	—
FCER1G P30273	✗	—	—
SYK P43405	✗	—	—
PIK3CG P48736	✗	—	—
PLCG2 P16885	✓	166/167	✗
BTK Q06187	✗	—	—

Tree

Fc-gamma receptor signaling pathwaySignaling Pathwayfc_gamma_receptor_signaling

Parts
1. 1. fcgamma receptor engagement
2. Fc-gamma receptor engagementRegulatory Stepfc_gamma_receptor_engagement
  
  Annotons
  - Fc-gamma receptor IIA Gene Product: FCGR2A
  - Fc-gamma receptor IIIA Gene Product: FCGR3A
  - Fc receptor gamma ITAM subunit Gene Product: FCER1G
3. 2. fcgamma syk-btk activation
4. SYK-BTK activation downstream of Fc-gamma receptorsRegulatory Stepsyk_btk_activation_downstream_of_fc_gamma_receptors
  
  Annotons
  - SYK tyrosine kinase Family: SYK tyrosine kinase family/ortholog group
  - BTK tyrosine kinase Family: BTK tyrosine kinase family/ortholog group
5. 3. fcgamma phagocytic output
6. Fc-gamma phagocytic outputRegulatory Stepfc_gamma_phagocytic_output
  
  Annotons
  - PLCG2 effector Gene Product: PLCG2
  - PI3K gamma catalytic branch Family: PI3K gamma catalytic branch family/ortholog group

Details

Context

jawed vertebratesNCBITaxon:7776

plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Fc-gamma receptor signaling pathwaySignaling Pathwayfc_gamma_receptor_signaling

Fc-gamma receptor signaling pathwayGO:0038094

Context

jawed vertebratesNCBITaxon:7776

plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

fc_gamma_receptor_engagement -> syk_btk_activation_downstream_of_fc_gamma_receptors Causes

The initiating event promotes fcgamma syk-btk activation.

syk_btk_activation_downstream_of_fc_gamma_receptors -> fc_gamma_phagocytic_output Causes

SYK-BTK activation downstream of Fc-gamma receptors leads to fcgamma phagocytic output.

Part 1: fcgamma receptor engagement

Fc-gamma receptor engagementRegulatory Stepfc_gamma_receptor_engagement

FCGR2A, FCGR3A, and FCER1G exemplify IgG Fc receptor signaling subunits.

Annotons

Fc-gamma receptor IIA

fcgr2a_fc_gamma_receptor_iia

Participant: Gene Product: FCGR2A

Gene Product:

FCGR2AUniProtKB:P12318

Curated exemplar for the fc-gamma receptor iia role in Fc-gamma receptor signaling pathway.

Fc-gamma receptor IIIA

fcgr3a_fc_gamma_receptor_iiia

Participant: Gene Product: FCGR3A

Gene Product:

FCGR3AUniProtKB:P08637

Curated exemplar for the fc-gamma receptor iiia role in Fc-gamma receptor signaling pathway.

Fc receptor gamma ITAM subunit

fcer1g_fc_receptor_gamma_itam_subunit

Participant: Gene Product: FCER1G

Gene Product:

FCER1GUniProtKB:P30273

Curated exemplar for the fc receptor gamma itam subunit role in Fc-gamma receptor signaling pathway.

Part 2: fcgamma syk-btk activation

SYK-BTK activation downstream of Fc-gamma receptorsRegulatory Stepsyk_btk_activation_downstream_of_fc_gamma_receptors

ITAM signaling recruits SYK and BTK-family kinase activity.

Annotons

SYK tyrosine kinase

syk_syk_tyrosine_kinase

Participant: Family: SYK tyrosine kinase family/ortholog group

Family:

SYK tyrosine kinase family/ortholog groupPANTHER:PTHR24418

Representative Members: SYKUniProtKB:P43405

Curated exemplar for the syk tyrosine kinase role in Fc-gamma receptor signaling pathway.

BTK tyrosine kinase

btk_btk_tyrosine_kinase

Participant: Family: BTK tyrosine kinase family/ortholog group

Family:

BTK tyrosine kinase family/ortholog groupPANTHER:PTHR24418

Representative Members: BTKUniProtKB:Q06187

Curated exemplar for the btk tyrosine kinase role in Fc-gamma receptor signaling pathway.

Part 3: fcgamma phagocytic output

Fc-gamma phagocytic outputRegulatory Stepfc_gamma_phagocytic_output

PLCG2 and PI3K branches relay Fc-gamma receptor input to calcium, actin, and phagocytic responses.

Annotons

PLCG2 effector

plcg2_plcg2_effector

Participant: Gene Product: PLCG2

Gene Product:

PLCG2UniProtKB:P16885

Curated exemplar for the plcg2 effector role in Fc-gamma receptor signaling pathway.

PI3K gamma catalytic branch

pik3cg_pi3k_gamma_catalytic_branch

Participant: Family: PI3K gamma catalytic branch family/ortholog group

Family:

PI3K gamma catalytic branch family/ortholog groupPANTHER:PTHR10048

Representative Members: PIK3CGUniProtKB:P48736

Curated exemplar for the pi3k gamma catalytic branch role in Fc-gamma receptor signaling pathway.