FGFR signaling pathway module

FGF ligands and heparan sulfate cofactor activate FGFR receptor tyrosine kinases, recruiting FRS2/GRB2/SOS, PI3K, PLCG, and MAPK outputs for development, angiogenesis, and tissue repair.

MODULE:fgfr_signalingDRAFTSignaling Pathwaymodules/fgfr_signaling.yaml
fibroblast growth factor receptor signaling pathwayGO:0008543
file:modules/fgfr_signaling-deep-research-falcon.md
FGFR signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0008543
fibroblast growth factor receptor signaling pathway
The module is grounded in the GO biological process term for fibroblast growth factor receptor signaling pathway.
PANTHER:PTN004704281
PAINT node PTN004704281 for FGFR1
Local PAINT IBD node in PTHR24416 with propagated terms P:GO:0008284, P:GO:0008543, P:GO:0043410; PAINT date 20250904.
PANTHER:PTN001230349
PAINT node PTN001230349 for FGFR1
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, C:GO:0043235, F:GO:0004714, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN005273574
PAINT node PTN005273574 for GRB2
Local PAINT IBD node in PTHR46037 with propagated terms C:GO:0005737, C:GO:0005886, C:GO:0008180, F:GO:0001784, F:GO:0005154, P:GO:0007165; PAINT date 20260530.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • fgfr_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (0/6 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 6 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
FGF2 P09038 ✗ — —
FGFR1 P11362 ✗ — —
PIK3R1 P27986 ✗ — —
GRB2 P62993 ✗ — —
SOS1 Q07889 ✗ — —
FRS2 Q8WU20 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
FGFR signaling pathwaySignaling Pathwayfgfr_signaling
fibroblast growth factor receptor signaling pathwayGO:0008543
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes frs2/grb2 scaffold assembly.
FRS2/GRB2 scaffold assembly leads to mapk and pi3k output.
Part 1: fgf ligand binds fgfr
FGF ligand binds FGFRRegulatory Stepfgf_fgfr_binding

FGF ligand, heparan sulfate, and FGFR form an active receptor complex.

Annotons

FGF2 ligand
fgf2_fgf2_ligand
Participant: Gene Product: FGF2
Gene Product:
FGF2UniProtKB:P09038

Function

signaling receptor bindingGO:0005102

Curated exemplar for the fgf2 ligand role in fibroblast growth factor receptor signaling pathway.

FGFR1 receptor kinase
fgfr1_fgfr1_receptor_kinase
Participant: Family: FGFR1 receptor kinase family/ortholog group
Family:
FGFR1 receptor kinase family/ortholog groupPANTHER:PTHR24416
Representative Members: FGFR1UniProtKB:P11362

Function

transmembrane receptor protein tyrosine kinase activityGO:0004714

Curated exemplar for the fgfr1 receptor kinase role in fibroblast growth factor receptor signaling pathway.

Part 2: frs2/grb2 scaffold assembly
FRS2/GRB2 scaffold assemblyReactionfrs2_grb2_scaffold

Activated FGFR phosphorylates FRS2 to recruit GRB2 and SOS.

Annotons

FRS2 adaptor
frs2_frs2_adaptor
Participant: Gene Product: FRS2
Gene Product:
FRS2UniProtKB:Q8WU20

Curated exemplar for the frs2 adaptor role in fibroblast growth factor receptor signaling pathway.

GRB2 adaptor
grb2_grb2_adaptor
Participant: Family: GRB2 adaptor family/ortholog group
Family:
GRB2 adaptor family/ortholog groupPANTHER:PTHR46037
Representative Members: GRB2UniProtKB:P62993

Curated exemplar for the grb2 adaptor role in fibroblast growth factor receptor signaling pathway.

Part 3: mapk and pi3k output
MAPK and PI3K outputRegulatory Stepfgfr_mapk_output

FRS2-centered scaffolds route the signal to Ras-MAPK and PI3K branches.

Annotons

SOS1 Ras GEF
sos1_sos1_ras_gef
Participant: Gene Product: SOS1
Gene Product:
SOS1UniProtKB:Q07889

Function

guanyl-nucleotide exchange factor activityGO:0005085

Curated exemplar for the sos1 ras gef role in fibroblast growth factor receptor signaling pathway.

PIK3R1 p85 adaptor
pik3r1_pik3r1_p85_adaptor
Participant: Family: PIK3R1 p85 adaptor family/ortholog group
Family:
PIK3R1 p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pik3r1 p85 adaptor role in fibroblast growth factor receptor signaling pathway.