A compact Gs-coupled GPCR signaling module. An agonist-occupied GPCR activates heterotrimeric Gs, G alpha s stimulates adenylyl cyclase, cAMP accumulates and activates PKA, and PKA phosphorylates cytosolic and nuclear substrates including CREB. The module is grounded in GO:0007188. ADRB2 is anchored to PAINT GPCR nodes; downstream GNAS, ADCY5, PRKACA, and CREB1 are curated UniProt exemplars without PTN ancestry claims in this first pass.
All recommended fields populated.
✗ none found
No MODULE:gpcr_camp_pka_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 complete review(s) · 2 with deep research · 3 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| ADRB2 P07550 | ✓ | ✓ | ✓ |
| CREB1 P16220 | ✓ | 143/146 | ✓ |
| ADCY5 O95622 | ✗ | — | — |
| PRKACA P17612 | ✗ | — | — |
| GNAS P63092 | ✗ | — | — |
Agonist-bound GPCR acts as a guanine nucleotide exchange factor for the heterotrimeric G protein, producing active G alpha s-GTP.
Receptor exemplar for agonist-driven Gs activation.
GTP-bound alpha subunit that stimulates adenylyl cyclase.
G alpha s activates membrane adenylyl cyclase to convert ATP to cAMP.
Enzyme tier that generates the cAMP second messenger.
cAMP binds PKA regulatory subunits, freeing catalytic subunits to phosphorylate substrates including CREB-family transcription factors.
cAMP-responsive kinase output of the pathway.
Nuclear transcriptional effector phosphorylated by PKA.