A compact Gs-coupled GPCR signaling module. An agonist-occupied GPCR activates heterotrimeric Gs, G alpha s stimulates adenylyl cyclase, cAMP accumulates and activates PKA, and PKA phosphorylates cytosolic and nuclear substrates including CREB. The module is grounded in GO:0007188. ADRB2 is anchored to PAINT GPCR nodes; downstream GNAS, ADCY5, PRKACA, and CREB1 are curated UniProt exemplars without PTN ancestry claims in this first pass.
All recommended fields populated.
✗ none found
No MODULE:gpcr_camp_pka_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 3 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| beta2_adrenergic_receptor | ADRB2 UniProtKB:P07550 Family Representative |
G protein-coupled receptor activity GO:0004930 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| adenylyl_cyclase | ADCY5 UniProtKB:O95622 Gene |
adenylate cyclase activity GO:0004016 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| pka_catalytic_subunit | PRKACA UniProtKB:P17612 Gene |
protein serine/threonine kinase activity GO:0004674 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| beta2_adrenergic_receptor | class A Gs-coupled GPCRs PANTHER:PTHR24248 Family |
G protein-coupled receptor activity GO:0004930 |
Family Review Missing
No supported structured family review is available for PANTHER:PTHR24248. |
1 complete review(s) · 2 with deep research · 3 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| ADRB2 P07550 | ✓ | ✓ | ✓ |
| CREB1 P16220 | ✓ | 143/146 | ✓ |
| ADCY5 O95622 | ✗ | — | — |
| PRKACA P17612 | ✗ | — | — |
| GNAS P63092 | ✗ | — | — |
Agonist-bound GPCR acts as a guanine nucleotide exchange factor for the heterotrimeric G protein, producing active G alpha s-GTP.
Receptor exemplar for agonist-driven Gs activation.
GTP-bound alpha subunit that stimulates adenylyl cyclase.
G alpha s activates membrane adenylyl cyclase to convert ATP to cAMP.
Enzyme tier that generates the cAMP second messenger.
cAMP binds PKA regulatory subunits, freeing catalytic subunits to phosphorylate substrates including CREB-family transcription factors.
cAMP-responsive kinase output of the pathway.
Nuclear transcriptional effector phosphorylated by PKA.