A compact vertebrate Hedgehog signaling module. Secreted Hedgehog ligand binds Patched, relieving Patched-mediated inhibition of Smoothened. Activated Smoothened accumulates in the primary cilium and shifts GLI transcription factors from repressor processing toward activator output. The module is grounded in GO:0007224, with curated UniProt exemplars for ligand, receptor, transducer, inhibitor, and GLI output; PTN ancestry is recorded only for Smoothened and SUFU, where the local PAINT cache has matching IBD seed rows.
SHH, PTCH1, and GLI1 are included as curated human exemplars, but no ancestral_nodes are asserted for them because their accessions did not resolve to matching IBD seed rows in the local interpro/panther cache.
All recommended fields populated.
✗ none found
No MODULE:hedgehog_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 complete review(s) · 0 with deep research · 5 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| GLI1 P08151 | ✗ | — | — |
| PTCH1 Q13635 | ✗ | — | — |
| SHH Q15465 | ✗ | — | — |
| SMO Q99835 | ✗ | — | — |
| SUFU Q9UMX1 | ✗ | — | — |
Processed Hedgehog ligand binds the Patched receptor, relieving Patched-mediated suppression of Smoothened and licensing ciliary Smoothened activation.
Secreted morphogen that initiates the pathway by binding Patched.
Twelve-pass membrane receptor that inhibits Smoothened when ligand is absent.
Once Patched repression is relieved, Smoothened becomes active and accumulates in the ciliary signaling compartment, promoting GLI activator formation.
GPCR-like transducer that carries the ligand-receptor state to the GLI regulatory module.
In the off state, SUFU restrains GLI transcription factors and favors repressor processing. Smoothened activation relieves this constraint, allowing GLI activators to drive Hedgehog target genes.
Negative regulator that restrains GLI factors in the pathway-off state.
Transcriptional effector converting Smoothened activity into Hedgehog target-gene expression.