HGF-MET signaling pathway module

Hepatocyte growth factor activates the MET receptor tyrosine kinase, recruiting multisite docking adaptors that coordinate motility, invasive growth, survival, and epithelial morphogenesis.

MODULE:hgf_met_signalingDRAFTSignaling Pathwaymodules/hgf_met_signaling.yaml
hepatocyte growth factor receptor signaling pathwayGO:0048012
file:modules/hgf_met_signaling-deep-research-falcon.md
HGF-MET signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0048012
hepatocyte growth factor receptor signaling pathway
The module is grounded in the GO biological process term for hepatocyte growth factor receptor signaling pathway.
PANTHER:PTN001230349
PAINT node PTN001230349 for MET
Local PAINT IBD node in PTHR24416 with propagated terms C:GO:0005886, P:GO:0007169; PAINT date 20260529.
PANTHER:PTN005273574
PAINT node PTN005273574 for GRB2
Local PAINT IBD node in PTHR46037 with propagated terms C:GO:0005737, C:GO:0005886, C:GO:0008180, F:GO:0001784, F:GO:0005154, P:GO:0007165; PAINT date 20260530.
PANTHER:PTN008302071
PAINT node PTN008302071 for PIK3R1
Local PAINT IBD node in PTHR10155 with propagated terms C:GO:0005943; PAINT date 20240516.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
6Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • hgf_met_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (0/5 grounded genes reviewed)

0 complete review(s) · 0 with deep research · 5 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
MET P08581 ✗ — —
HGF P14210 ✗ — —
PIK3R1 P27986 ✗ — —
GRB2 P62993 ✗ — —
GAB1 Q13480 ✗ — —

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
HGF-MET signaling pathwaySignaling Pathwayhgf_met_signaling
hepatocyte growth factor receptor signaling pathwayGO:0048012
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes met docking-platform assembly.
MET docking-platform assembly leads to motility and growth output.
Part 1: hgf-met ligation
HGF engages METRegulatory Stephgf_engages_met

HGF binding activates MET receptor tyrosine kinase dimers.

Annotons

HGF ligand
hgf_hgf_ligand
Participant: Gene Product: HGF
Gene Product:
HGFUniProtKB:P14210

Curated exemplar for the hgf ligand role in hepatocyte growth factor receptor signaling pathway.

MET receptor
met_met_receptor
Participant: Family: MET receptor family/ortholog group
Family:
MET receptor family/ortholog groupPANTHER:PTHR24416
Representative Members: METUniProtKB:P08581

Curated exemplar for the met receptor role in hepatocyte growth factor receptor signaling pathway.

Part 2: met docking-platform assembly
MET docking-platform assemblyRegulatory Stepmet_docking_platform_assembly

MET phosphotyrosines recruit GAB1 and GRB2 adaptor complexes.

Annotons

GAB1 docking adaptor
gab1_gab1_docking_adaptor
Participant: Gene Product: GAB1
Gene Product:
GAB1UniProtKB:Q13480

Curated exemplar for the gab1 docking adaptor role in hepatocyte growth factor receptor signaling pathway.

GRB2 adaptor
grb2_grb2_adaptor
Participant: Family: GRB2 adaptor family/ortholog group
Family:
GRB2 adaptor family/ortholog groupPANTHER:PTHR46037
Representative Members: GRB2UniProtKB:P62993

Curated exemplar for the grb2 adaptor role in hepatocyte growth factor receptor signaling pathway.

Part 3: motility and growth output
MET motility and growth outputRegulatory Stepmet_motility_and_growth_output

MET-driven adaptor complexes activate PI3K and Ras-MAPK signaling branches.

Annotons

PI3K p85 adaptor
pik3r1_pi3k_p85_adaptor
Participant: Family: PI3K p85 adaptor family/ortholog group
Family:
PI3K p85 adaptor family/ortholog groupPANTHER:PTHR10155
Representative Members: PIK3R1UniProtKB:P27986

Curated exemplar for the pi3k p85 adaptor role in hepatocyte growth factor receptor signaling pathway.

MET kinase output
met_met_kinase_output
Participant: Family: MET kinase output family/ortholog group
Family:
MET kinase output family/ortholog groupPANTHER:PTHR24416
Representative Members: METUniProtKB:P08581

Curated exemplar for the met kinase output role in hepatocyte growth factor receptor signaling pathway.