A compact Hippo pathway module. Upstream polarity, junctional, mechanical, and stress inputs activate the MST1/2 kinase tier, which activates LATS1/2 kinases through scaffolded phosphorylation. Active LATS1/2 phosphorylate YAP/TAZ, causing cytoplasmic retention or degradation and suppressing TEAD-dependent growth programs. When the kinase cassette is inactive, YAP/TAZ enter the nucleus and coactivate TEAD transcription factors. The module is grounded in GO:0035329, with PAINT anchors for STK4/MST1 and LATS1 where local seed rows support the kinase-pathway roles.
All recommended fields populated.
✗ none found
No MODULE:hippo_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
1 gene-function check(s) reflected in core functions · 0 conflict(s) · 3 evidence or coverage gap(s) (4 comparison(s))
Retained noncore functions are reported separately; they do not require promotion to core functions. Support from representative genes does not establish conservation across the whole family. Missing reviews or identifiers leave a claim unverified.
| Annoton | Participant | Function | Assessment |
|---|---|---|---|
| mst_kinase | STK4 UniProtKB:Q13043 Family Representative |
protein serine/threonine kinase activity GO:0004674 |
Review Missing
No ai-review exists for this protein; its function and core-function coverage cannot yet be checked. |
| lats_kinase | LATS1 UniProtKB:O95835 Family Representative |
protein serine/threonine kinase activity GO:0004674 |
Core Supported
The GO molecular function is reflected in core_functions (exact term or a reviewed subclass). |
| mst_kinase | MST/Hippo STE20-family kinases PANTHER:PTHR48012 Family |
protein serine/threonine kinase activity GO:0004674 |
Family Review Missing
No supported structured family review is available for PANTHER:PTHR48012. |
| lats_kinase | LATS/Warts AGC kinases PANTHER:PTHR24356 Family |
protein serine/threonine kinase activity GO:0004674 |
Family Review Missing
No supported structured family review is available for PANTHER:PTHR24356. |
✓ every negative regulator described as feedback has an upstream edge closing the loop.
1 complete review(s) · 0 with deep research · 2 missing review · 3 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| LATS1 O95835 | ✓ | 100/105 | ✗ |
| NF2 P35240 | ✗ | — | — |
| STK4 Q13043 | ✗ | — | — |
| TEAD1 P28347 | ✓ | ✓ | ✗ |
| YAP1 P46937 | ✓ | 312/314 | ✗ |
Cell-junction, polarity, cytoskeletal, and mechanical inputs converge on scaffolded activation of the MST1/2 kinase tier.
Upstream membrane-cytoskeleton scaffold that promotes Hippo kinase activation in many contexts.
Proximal kinase tier that activates LATS1/2.
MST1/2 and scaffold proteins activate LATS1/2, the direct YAP/TAZ kinases.
Direct kinase tier that phosphorylates and inhibits YAP/TAZ.
LATS phosphorylation keeps YAP/TAZ out of the nucleus or promotes degradation. When Hippo kinase signaling is low, YAP/TAZ enter the nucleus and coactivate TEAD transcription factors.
Regulated transcriptional coactivator controlled by LATS phosphorylation.
DNA-binding partner used by nuclear YAP/TAZ to drive growth-control genes.