A compact Hippo pathway module. Upstream polarity, junctional, mechanical, and stress inputs activate the MST1/2 kinase tier, which activates LATS1/2 kinases through scaffolded phosphorylation. Active LATS1/2 phosphorylate YAP/TAZ, causing cytoplasmic retention or degradation and suppressing TEAD-dependent growth programs. When the kinase cassette is inactive, YAP/TAZ enter the nucleus and coactivate TEAD transcription factors. The module is grounded in GO:0035329, with PAINT anchors for STK4/MST1 and LATS1 where local seed rows support the kinase-pathway roles.
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No MODULE:hippo_signaling deep-research report alongside the module YAML.
✓ every leaf node grounds to a representative protein.
✓ every declared conforms_to bundle matches its template motif.
0 complete review(s) · 0 with deep research · 5 missing review · 0 reviewed but lacking deep research
| Gene | Review | Complete | Deep research |
|---|---|---|---|
| LATS1 O95835 | ✗ | — | — |
| TEAD1 P28347 | ✗ | — | — |
| NF2 P35240 | ✗ | — | — |
| YAP1 P46937 | ✗ | — | — |
| STK4 Q13043 | ✗ | — | — |
Cell-junction, polarity, cytoskeletal, and mechanical inputs converge on scaffolded activation of the MST1/2 kinase tier.
Upstream membrane-cytoskeleton scaffold that promotes Hippo kinase activation in many contexts.
Proximal kinase tier that activates LATS1/2.
MST1/2 and scaffold proteins activate LATS1/2, the direct YAP/TAZ kinases.
Direct kinase tier that phosphorylates and inhibits YAP/TAZ.
LATS phosphorylation keeps YAP/TAZ out of the nucleus or promotes degradation. When Hippo kinase signaling is low, YAP/TAZ enter the nucleus and coactivate TEAD transcription factors.
Regulated transcriptional coactivator controlled by LATS phosphorylation.
DNA-binding partner used by nuclear YAP/TAZ to drive growth-control genes.