IL-1 signaling pathway module

IL-1 cytokines activate IL1R1/IL1RAP receptor complexes and MyD88-IRAK-TRAF6 signaling assemblies to induce NF-kappaB and inflammatory transcriptional responses.

MODULE:il1_signalingDRAFTSignaling Pathwaymodules/il1_signaling.yaml
interleukin-1-mediated signaling pathwayGO:0070498
file:modules/il1_signaling-deep-research-falcon.md
IL-1 signaling pathway Falcon module review
Falcon/Edison module review generated 2026-06-28 is linked as supporting evidence for module boundaries, core mechanism, variation, constraints, and failure modes; open questions in that report require manual review before promotion to curated knowledge gaps.
GO:0070498
interleukin-1-mediated signaling pathway
The module is grounded in the GO biological process term for interleukin-1-mediated signaling pathway.
PANTHER:PTN000008680
PAINT node PTN000008680 for IL1B
Local PAINT IBD node in PTHR10078 with propagated terms P:GO:0043123, P:GO:0070372; PAINT date 20250411.
PANTHER:PTN000223709
PAINT node PTN000223709 for IL1R1
Local PAINT IBD node in PTHR11890 with propagated terms F:GO:0004908; PAINT date 20240409.
PANTHER:PTN000223712
PAINT node PTN000223712 for IL1R1
Local PAINT IBD node in PTHR11890 with propagated terms P:GO:0070498; PAINT date 20190308.
PANTHER:PTN000805648
PAINT node PTN000805648 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms P:GO:0043122; PAINT date 20260528.
PANTHER:PTN000934584
PAINT node PTN000934584 for IL1RAP
Local PAINT IBD node in PTHR11890 with propagated terms P:GO:0019221; PAINT date 20240409.
PANTHER:PTN002560644
PAINT node PTN002560644 for IL1B
Local PAINT IBD node in PTHR10078 with propagated terms C:GO:0005576, F:GO:0005125, P:GO:0006954, P:GO:0019221; PAINT date 20260528.
PANTHER:PTN002628173
PAINT node PTN002628173 for IL1R1
Local PAINT IBD node in PTHR11890 with propagated terms C:GO:0005886, P:GO:0007166; PAINT date 20260528.
PANTHER:PTN008301857
PAINT node PTN008301857 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms P:GO:0007166; PAINT date 20250411.
PANTHER:PTN008494376
PAINT node PTN008494376 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms F:GO:0061630, P:GO:0045087; PAINT date 20230602.
PANTHER:PTN008938480
PAINT node PTN008938480 for TRAF6
Local PAINT IBD node in PTHR10131 with propagated terms C:GO:0005737; PAINT date 20260528.

Curated compact signaling-pathway module generated from verified UniProt exemplar accessions and local PAINT IBD rows. PTN anchors are included only when the exemplar accession appears in an IBD seed row in interpro/panther; roles without local PAINT seeds remain grounded by verified UniProt exemplar accessions. Falcon integration (2026-06-28): Falcon findings are linked as evidence and family-level support. Automatically extracted open-question headings were intentionally not retained as knowledge_gap entries because they were not manually curated. Machine-generated Falcon citations remain curation support and are not manually adjudicated here.

4Nodes
3Parts
0Variant Sets
0Variants
7Annotons
2Connections

Derived QC

Recommended-field compliance

100.0% recommended fields populated

All recommended fields populated.

Module deep research

✓ present

  • il1_signaling-deep-research-falcon.md (falcon)

Leaf nodes lacking representative members

✓ every leaf node grounds to a representative protein.

Template conformance

✓ every declared conforms_to bundle matches its template motif.

Gene-review completeness (1/6 grounded genes reviewed)

0 complete review(s) · 1 with deep research · 5 missing review · 0 reviewed but lacking deep research

Gene Review Complete Deep research
IL1B P01584 ✗ — —
IL1R1 P14778 ✗ — —
MYD88 Q99836 ✗ — —
IL1RAP Q9NPH3 ✗ — —
IRAK4 Q9NWZ3 ✗ — —
TRAF6 Q9Y4K3 ✓ 402/404 ✓

Details

Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634
IL-1 signaling pathwaySignaling Pathwayil1_signaling
interleukin-1-mediated signaling pathwayGO:0070498
Context
metazoaNCBITaxon:33208
plasma membraneGO:0005886 cytosolGO:0005829 nucleusGO:0005634

Connections

The initiating event promotes myddosome assembly.
MyD88-IRAK signaling assembly leads to traf6 inflammatory output.
Part 1: il1 receptor engagement
IL-1 receptor engagementRegulatory Stepil_1_receptor_engagement

IL1B engages IL1R1 and IL1RAP receptor complexes.

Annotons

IL-1 beta cytokine
il1b_il_1_beta_cytokine
Participant: Family: IL-1 beta cytokine family/ortholog group
Family:
IL-1 beta cytokine family/ortholog groupPANTHER:PTHR10078
Representative Members: IL1BUniProtKB:P01584

Curated exemplar for the il-1 beta cytokine role in interleukin-1-mediated signaling pathway.

IL1 receptor type 1
il1r1_il1_receptor_type_1
Participant: Family: IL1 receptor type 1 family/ortholog group
Family:
IL1 receptor type 1 family/ortholog groupPANTHER:PTHR11890
Representative Members: IL1R1UniProtKB:P14778

Curated exemplar for the il1 receptor type 1 role in interleukin-1-mediated signaling pathway.

IL1 receptor accessory protein
il1rap_il1_receptor_accessory_protein
Participant: Family: IL1 receptor accessory protein family/ortholog group
Family:
IL1 receptor accessory protein family/ortholog groupPANTHER:PTHR11890
Representative Members: IL1RAPUniProtKB:Q9NPH3

Curated exemplar for the il1 receptor accessory protein role in interleukin-1-mediated signaling pathway.

Part 2: myddosome assembly
MyD88-IRAK signaling assemblyRegulatory Stepmyd88_irak_signaling_assembly

MyD88 and IRAK4 form a proximal IL-1 receptor signaling platform.

Annotons

MyD88 adaptor
myd88_myd88_adaptor
Participant: Gene Product: MYD88
Gene Product:
MYD88UniProtKB:Q99836

Curated exemplar for the myd88 adaptor role in interleukin-1-mediated signaling pathway.

IRAK4 kinase
irak4_irak4_kinase
Participant: Gene Product: IRAK4
Gene Product:
IRAK4UniProtKB:Q9NWZ3

Curated exemplar for the irak4 kinase role in interleukin-1-mediated signaling pathway.

Part 3: traf6 inflammatory output
TRAF6 inflammatory outputRegulatory Steptraf6_inflammatory_output

TRAF6 relays IL-1 receptor input to NF-kappaB and MAPK inflammatory outputs.

Annotons

TRAF6 E3 adaptor
traf6_traf6_e3_adaptor
Participant: Family: TRAF6 E3 adaptor family/ortholog group
Family:
TRAF6 E3 adaptor family/ortholog groupPANTHER:PTHR10131
Representative Members: TRAF6UniProtKB:Q9Y4K3

Curated exemplar for the traf6 e3 adaptor role in interleukin-1-mediated signaling pathway.

IRAK4 signaling kinase
irak4_irak4_signaling_kinase
Participant: Gene Product: IRAK4
Gene Product:
IRAK4UniProtKB:Q9NWZ3

Curated exemplar for the irak4 signaling kinase role in interleukin-1-mediated signaling pathway.